著者
片岡 陽平 松江 高仁 片桐 弘 葉柴 崇文 半澤 元章 津野田 亮
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.66, no.3, pp.157-161, 2020-03-20 (Released:2020-05-20)
参考文献数
23
被引用文献数
1

Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a recently recognized B-cell lymphoproliferative disorder that is driven by latent EBV infection and causes discrete ulcerations in the oropharynx, gastrointestinal tract, and skin. A 56-year-old Japanese woman with a 1-month history of swelling in the right side of lower gingiva visited our hospital. The patient had a past medical history of rheumatoid arthritis (RA). She had been given a diagnosis of RA in 1981 and had received standard treatment with methotrexate (MTX) (8 mg/week) for more than 26 years (total dose, greater than 3840 mg). Following initial biopsy and withdrawal of the MTX, the area healed spontaneously over a period of several weeks. The morphological and immunophenotype features were in keeping with an EBV-related lymphoproliferative lesion consistent with EBVMCU. We requested discontinuation of methotrexate, and the lesion decreased and symptoms disappeared in 2 months. There was no evidence of recurrence 25 months after discontinuing methotrexate.
著者
半澤 元章
雑誌
北海道歯学雑誌 (ISSN:09147063)
巻号頁・発行日
vol.17, no.2, pp.286-298, 1996-12-15
参考文献数
59
被引用文献数
1