著者
川田 賢介 河原 正和 秋森 俊行 山口 朋子 岡本 喜之 石川 好美
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.54, no.7, pp.423-426, 2008-07-20 (Released:2011-04-22)
参考文献数
23
被引用文献数
1 1

Oral mucosal lesions associated with foreign body injuries can have various origins, but traumatic lesions of the oral mucosa caused by other organisms are rare. Such cases thus require special knowledge for diagnosis. We report a case of oral stings from spermatophores of Todarodes pacificus, the Pacific squid. The patient was a 31-year-old woman who cooked the internal organs of a raw T. pacificus for lunch. She experienced a sharp pain on the tongue and buccal mucosa when eating the organs. On checking the oral cavity, she identified multiple white objects with a worm-like appearance sticking into the tongue and oral mucosa. Attempts to remove these objects herself were unsuccessful. She then visited the emergency department of our hospital. We examined the oral cavity and found multiple white objects appearing to be parasitic worms sticking into the tongue and oral mucosa. Attempts to remove the objects with forceps were unsuccessful because of tight attachment to the mucosa. Removal was thus achieved by making slight incisions under local anesthesia. The specimens showed a white spinate shape and were about 4mm long. Endoscopic examination of the upper digestive tract after treatment of the oral cavity revealed no additional foreign bodies. The final pathological diagnosis was spermatophores of T. pacificus.
著者
下村 忠弘 山本 一彦 栗原 都 柳生 貴裕 高野 梨沙 桐田 忠昭
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.58, no.10, pp.600-603, 2012-10-20 (Released:2014-11-20)
参考文献数
18

A case of sting wounds of the oral mucosa caused by spermatophores of a raw squid is reported. The patient was a 61-year-old woman. She noticed pain of the oral mucosa immediately after eating part of a raw squid. Several milky white, club-shaped foreign bodies measuring 3 to 5 mm were stuck in the tongue, buccal mucosa, and floor of the mouth. These were not mobile and were hard to remove. The clinical diagnosis was sting wounds of the oral mucosa caused by spermatophores of a squid. These foreign bodies were excised together with the surrounding tissue under local anesthesia. Wound healing was uneventful. Histologically, the foreign bodies contained numerous spermatozoa and were identified as spermatothecae, which were ejected from the spermatophores of a raw squid.
著者
木下 靖朗 冨田 陽二 早瀬 智広 中野 稔也
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.39, no.9, pp.993-995, 1993-09-20 (Released:2011-07-25)
参考文献数
13

This report presents rate two cases of foreign bodies (sperm-bags of squid) in the oral cavity, which were found in a 38-year-old male and 49-year-old female.Several small thorn-shaped foreign bodies stuck in the oral mucosa were observed and removed successfully.
著者
小嶋 由子 栗田 浩 藤森 林 中塚 厚史 成川 純之助 倉科 憲治
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.51, no.12, pp.622-625, 2005-12-20 (Released:2011-04-22)
参考文献数
17
被引用文献数
1

Fibromyalgia syndrome is a disease characterized by chronic pain and multiple tender points over the entire body. The cause of the disease is unknown, and patients are sometimes have various uncertain complaints. In this paper, we report a case of temporomandibular disorders (TMD) accompanied by fibromyalgia.The patient was a 26-year-old woman who received treatments for autonomic imbalance and panic disorder at a psychosomatic clinic. She complained of strong malaise, headache, tinnitus, insomnia, and constipation. She also had bilateral pain of the masticatory and neck muscles and around the temporomandibular joints. The range of maximum mouth opening was 23mm. The patient had edge-to-edge occlusion in the molar region and slight open bite in the incisor region.She received a diagnosis of temporomandibular disorders of type I and fibromyalgia. The patient was successfully treated with a stabilization splint for temporomandibular disorders and antidepressants for fibromyalgia.
著者
中嶋 正博
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.58, no.8, pp.473-479, 2012-08-20 (Released:2014-11-14)
参考文献数
9
被引用文献数
1 1

Othognathic surgery for jaw deformities are most frequently performed in Japan. Regarding those procedures, Le Fort I osteotomy and anterior maxillary alveolar osteotomy in the maxilla, and sagittal split ramus osteotomy, intraoral vertical ramus osteotomy, anterior mandibular alveolar osteotomy, and genioplasty in the mandibule are selected singly or combined based on cases. Among these orthgnathic surgeries, Le Fort I osteotomy is a typical surgical procedure, as well as sagittal split ramus osteotomy. Although the designing of osteotomy lines in Le Fort I osteotomy is simple, this surgical procedure is apt to be regarded as difficult, due to other risk factors in comparison with mandibular osteotomy, such as difficulty in the repositioning of bone segment, complexity of the maxillary bone structure, bleeding, surgical invasion of the nasal cavity and paranasal sinus, and postoperative changes in the nasal base morphology. However, regarding surgical treatment for jaw deformities, Le Fort I osteotomy is considered to be a surgical procedure which we should master, as well as sagittal split ramus osteotomy.Basically, orthognathic surgeries involve subperiosteal surgical manipulation, and it is simply summarized that Le Fort I osteotomy should also be carefully performed without injuring the periosteum. In order to achieve this, it is necessary to accumulate experience, sufficiently understanding the basic factors to safely perform Le Fort I osteotomy. This manuscript outlines the major points in the surgical procedure of Le Fort I osteotomy.
著者
前田 初彦
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.8, pp.464-470, 2010-08-20 (Released:2013-10-31)
参考文献数
36

In humans over 120 human papillomavirus (HPV) types have been completely described. HPVs have also been classified as low and high risk HPV types based on the clinical behavior of the HPV infected tissues. HPV proteins, especially the oncoproteins E6 and E7 of the oncogenic HPVs, interact with different degrees of affinity, with host cell proteins to disturb the normal epithelial differentiation and apoptosis by stimulating cellular proliferation, DNA synthesis and inhibition of cell cycle regulators. The best characterized interactions so far are the interactions between E7 and pRb and E6 and p53. Continued and aberrant expression of the E6 and E7 genes of the high risk HPVs will lead to genomic instability which finally after accumulation of mutational events can result in malignant transformation. Persistent infection with high risk HPV increase the risk of squamous cell carcinoma, while the low risk HPV may be associated with benign lesions. Also, HPV infections can be detected in the oral cavity and HPVs have been described as being associated with malignant lesions, such as oral squamous cell carcinoma and with benign lesions such as leukoplakia and oral papilloma. It is suggested that oral mucosa might serve as a reservoir of HPVs. Now, an inoculation of vaccine preventing HPV infection is performed, and the result begins to appear for the prevention of the cervical cancer. In addition, an improvement in the state of oral hygiene decreases the rate of HPV infection, and indicated that oral care may be an effective way to prevent HPV infections. The present conditions and the future prospects of the prevention and the treatment of HPV infections in the oral region are reported.
著者
吉田 和也 梶 龍兒 飯塚 忠彦
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.46, no.10, pp.563-571, 2000-10-20
参考文献数
26
被引用文献数
3 1

Oromandibular dystonia is characterized by involuntary contraction of the masticatory and tongue muscles, causing difficulties in mastication or speech. Muscle afferent block (MAB) therapy by intramuscular injection of lidocaine and alcohol is aimed at reducing muscle spindle afferents. We treated 37 patients with oromandibular dystonia by intramuscularly injecting 5 to 10ml of 0.5% lidocaine with 0.5 to 1ml of 99.5% alcohol. The muscles for injection were chosen from among the masseter, the inferior head of the lateral pterygoid muscle, the anterior belly of the digastric muscle, the genioglossal muscle, the medical pterygoid muscle, the sternocleidomastoid muscle, and the trapezius muscle. The effect of therapy was assessed subjectively on a linear self-rating scale ranging from 0 (no improvement) to 100 points (complete cure). All patients showed clinical improvement with reduced EMG activity in the affected muscles. The mean number of injections was 10.1±5.8. The overall subjective improvement rate was 60.8±25.4%. Maximal mouth opening (26.0±7.7mm) in patients with restricted mouth opening increased significantly (<I>p</I><0.0001, <I>t</I> test) after treatment (37.1±7.6mm). Some patients had tenderness, stiffness, or swelling of the muscles after repeated injection. The discomfort disappeared spontaneously after discontinuing therapy. MAB therapy is an effective means of treating oromandibular dystonia that has no major side effects.
著者
渋谷 恭之
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.6, pp.346-351, 2010-06-20 (Released:2013-10-19)
参考文献数
14

The current foundation of preventing nosocomial infection in dental settings are “Guidelines for infection control in dental health-care settings” announced in 2003 by Centers for Disease Control and Prevention (CDC). These guidelines employ a concept of standard precaution in clinical dentistry, and had a great influence on “Guideline for infection control in dental prosthetics” established in 2007 by Japan Prosthodontic Society and “Guideline for infection control in dentistry” announced by the dental division of the infection control conference of the national university hospitals in 2008. On the other hand, there have been many reports about oral care, for instance, ‘1) oral care prevents aspiration-related pneumonia', ‘2) oral care decreases the onset rate of the influenza to a one-tenth, (oral care decreases significantly neuraminidase and protease which bacteria produce) ', ‘3) oral care reduces a side effect in the oral cavity by the chemoradiotherapy', ‘4) oral care prevents ventilator-associated pneumonia in ICU', ‘5) oral care is useful for symptom relief in terminal illness', and an importance of oral care has been widely noticed in late years.
著者
清水 正嗣 水城 春美 福山 義邦 松本 有史 河村 哲夫 柳沢 繁孝
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.37, no.7, pp.1380-1384, 1991-07-20 (Released:2011-07-25)
参考文献数
10

A case with fresh gunshot wound penetrating from the left lateral neck to the mouth angle, which was caused by pistol shooting during a conflict between gangs, was reported and discussed by us.The patient, a 41-year-old male, was shot probably with a 38-caliber revolver from behind. Its entrance was on the left rear of the neck, and the exit hole at the left mouth angle. The route through the body: the bullet passed inside of the mandible, where it caused a crashing fracture of the body in the molar region while breaking the lower prosthesis. But, he was very lucky that the important blood vessels and nerve bundles were not injured, although the route was very close to them. He was transported to our Dept. that same day and operated on under general anesthesia for removing foreign bodies, uniting and fixing the jaw fracture, and also for reconstructing the mouth angle, while we sanitized the wound and sutured the soft tissues at each place. At last, a tracheotomy was performed, to prevent suffocation from postoperative swelling. The progress after the operation was good, and he was discharged three weeks later. After 3 years he is now healthy and in prison.
著者
岩永 譲 古賀 千尋 加来 伸一郎 藤井 智津 岩本 修 楠川 仁悟
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.2, pp.95-97, 2010-02-20 (Released:2013-10-19)
参考文献数
9

A case of oral mucosal ulcer caused by the inappropriate use of nicotine gum is reported.The patient was a 55-year-old man who was a heavy smoker. He had smoked 60 cigarettes a day for 36 years. He had been using nicotine gum as a "stop-smoking aid" for over 8 months. He was referred to our department because of an unhealed undermining ulcer at the mucogingival junction of the lower right anterior teeth. On exfoliative cytology, there were no atypical cells in a specimen of the ulcer. Therefore, we recommended him to stop using nicotine gum, which was inappropriately placed at the buccal vestibule of mouth. The tenderness then gradually improved, and the ulcer healed in the month. Long-term inappropriate use of nicotine gum can cause adverse effects to the oral mucosa.
著者
篠崎 昌一 森山 雅文 林田 淳之介 田中 昭彦 前原 隆 古川 祥子 太田 美穂 今林 佑美 中村 誠司
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.61, no.3, pp.147-153, 2015-03-20 (Released:2015-09-29)
参考文献数
13

Objectives: Cevimeline hydrochloride (CH) and pilocarpine hydrochloride (PH) are recognized as salivation-inducers with a high affinity for M3 muscarinic receptors. However, these drugs have a high frequency of side effects, including digestive symptoms and hyperhidrosis. We compared the effectiveness and side effects of these two drugs before and after a medication change.Materials and Methods: Seventy-six patients with Sjögren's syndrome were divided into the following four groups: 1) CH group, CH was administered for 12 months; 2) PH group, PH was administered for 12 months; 3) CH-PH group, CH was administered for 6 months followed by PH for 6 months; 4) PH-CH group, PH was administered for 6 months followed by CH for 6 months. We measured the salivary flow rate and recorded the subjective symptoms in each group.Results: In each group, stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) significantly increased after 3 months and 6 months, respectively, and subjective symptoms improved after 3 months. The incremental changes in both SWS and UWS did not differ significantly between the groups. The CH and PH groups both had digestive symptoms (32.3% and 32.1%, respectively) and hyperhidrosis (29.0% and 39.3%, respectively). We found no significant difference in salivary flow rate or subjective symptoms after the medication change. However, the frequencies of side effects in the CH-PH and PH-CH groups decreased significantly for both digestive symptoms (9.7% and 10.7%, respectively) and hyperhidrosis (25.8% and 14.3%, respectively).Conclusions: After changing the salivation-inducing drug, there was no significant difference in salivary function or subjective symptoms, while the frequency of side effects markedly decreased. These results suggest that changing the salivation-inducing drug effectively reduces side effects.
著者
佐野 和生 荒木 正弘 小川 晶子 簔田 雄二 寺崎 宏 村上 秀樹 二宮 秀則 弘中 亮治 伊東 弦 北村 晃 井口 次夫
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.33, no.8, pp.1684-1690, 1987-08-20 (Released:2011-07-25)
参考文献数
17

Thirty patients with the temporomandibular disorders were treated with “Kakkonto”, one of the most famous traditional drugs for chronic diseases with pain.“Kakkon-to” was given orally in a dosage of 7.5g 3 times daily before meals for two weeks. Clinical evaluation was carried out at seventh and fourteenth day after administration about spontaneous pain, pain with jaw movement, muscular tenderness, complications, and side effects. These symptoms were rated on a scale of 0 to 3 (0=no symptom and 3=severe). Two cases were dropped because of further administration of another analgesic for severe temporomandibular joint pain. 22 of 28 (78.6%) patients were improved at the therapy completion. 6 cases (21.4%) showed significant improvement, most of those had complications such as stiff shoulder and headache. Side effects were observed in 5 cases, such as slight nausea, vomiting and so on. It is suggested that “Kakkon-to” is a useful drug for temporomandibular disorders.
著者
木下 一彦 水野 裕和 日比 英晴
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.65, no.6, pp.424-428, 2019-06-20 (Released:2019-08-20)
参考文献数
17

A case of multiple sialolithiasis in the submandibular gland and duct is reported. A 71-year-old man was referred to the Department of Oral and Maxillofacial Surgery in our hospital. He had no symptoms in the right submandibular region, but panoramic radiography and computed tomography showed multiple calculi in the right submandibular gland and duct. The patient underwent excision of the right submandibular gland with Wharton’s duct including multiple stones. A total of 332 sialoliths were detected, and the submandibular gland tissues were normal histopathologically. The postoperative period was uneventful, and the patient recovered without any complications. This is a rare case with the largest number of sialoliths ever reported.
著者
奥田 克爾
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.4, pp.231-239, 2010-04-20 (Released:2013-10-19)
参考文献数
29

Oral biofilm-forming bacteria consist of a dense bacterial mass tightly adhering to the surface of the oral cavity. The characteristics of dental biofilm are resistant against not only host defense mechanisms but also various antimicrobial agents. The predominant bacteria forming biofilm result in persistent infection. The proteolytic enzymes, exotoxins, endotoxins, and HSPs of these bacteria play a significant role in the development of oral infectious disease and affect systemic condition.We detected DNA and antigen of Treponema denticola in atherosclerotic lesions, and also found that the 16S rRNAs of Porphyromonas gingivalis, Aggregatibacter (formally Actinobacillus) actinomycetemcomitans,Tannerella forsythia, T. denticola, and Campylobacter rectus in samples of stenotic coronary arterial plaque. We showed the invasive activity of these bacteria into human vein endothelial cells. Increasing evidence has linked the dental biofilm with respiratory infectious diseases such as aspiration pneumonia in elderly persons. We investigated the effects of oral health care for elderly persons requiring nursing care on prevention of influenza infection.In the oral care group, colony-forming cell number, neuraminidase and trypsin-like protease activities in saliva decreased. It was found that one of 98 patients was diagnosed with influenza; whereas, in the non-oral care group,nine of 92 patients were diagnosed with influenza. The finding indicates that oral hygiene is one of the effective strategies to prevent influenza infection. Periodontal surrounding cells such as macrophage possessing TLRs and CD14 that are endotoxin binding protein. Carrying endotoxin with macrophage to various tissues releases inflammatory cytokines such as TNF-αand IL-1 that produce resistance to insulin sensitivity and cause obesity and diabetes. An attempt to discover new things by studying the past through scrutiny of old, there are many evidences on the close relationship between the primary dental biofilm infectious diseases and secondly systemic diseases such as nephritis, dermatitis and arthritis.The author firmly believes that control of oral biofilm-forming infectious diseases by the surgical treatment is an essential strategy and management of such systemic conditions.
著者
吉田 雅之 大月 佳代子 大西 正俊
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.50, no.6, pp.368-371, 2004-06-20 (Released:2011-04-22)
参考文献数
9

Difficulty in extracting a foreign object embedded in tissue of the oromaxillofacial region is not uncommon. Arthroscopic surgery is often used to treat conditions of the temporomandibular joints. We successfully extracted foreign objects embedded in a cul-de-sac facial gunshot wound adjacent to the temporomandibular joint, using a rigid endoscope originally designed for temporomandibular arthroscopic surgery. The procedures used are described in this report.The patient was a 46-year-old man who had been shot in the left side of the face. The bullet lodged in tissue medial to the left temporomandibular joint and sphenoidal sinus. Without any additional incision, a temporomandibular arthroscope was introduced from the point of entry of the bullet beneath the eye socket with the patient under general anesthesia. A total of 34 objects, including the bullet, its fragments and glass fragments from the patient's eyeglasses, were endoscopically extracted with the use of a grasping forceps. Arthroscopic monitoring permitted visual confirmation of the foreign bodies and enabled their successful extraction with minimal invasion.
著者
深谷 千絵 矢郷 香 大塚 志穂 岡田 明子 中川 種昭 朝波 惣一郎
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.50, no.10, pp.624-627, 2004-10-20 (Released:2011-04-22)
参考文献数
10

Concool F®is a chemical mouthwash containing chlorhexidine gluconate that is used for the treatment of periodontal disease and halitosis. We report a case of gingival necrosis caused by incorrect use of Concool F®A 52-year-old woman was referred to our hospital because of gingival necrosis. One week before presentation, she went to sleep after putting a cotton roll soaked in a large amount of Concool F®solution (0.36 % chlorhexidine gluconate) on the upper gingiva to reduce bad breath. She noticed bleeding and a painful ulcer in the upper gum from the maxillary right lateral incisor to the left second premolar.Whenever a mouthwash agent containing chlorhexidine gluconate is used, we must be cautious about its usage and dosage and instruct the patients on proper use.
著者
泉 喜和子 下田 恒久 下田 哲也 香川 豊宏 池邉 哲郎 大関 悟
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.4, pp.261-265, 2010-04-20 (Released:2013-10-19)
参考文献数
13

This report describes the feasibility of posterior-superior repositioning of the maxilla by Le Fort Ⅰ osteotomy with a pterygoid process fracture, while preserving the descending palatine artery. We examined movement accuracy and stability in 3 patients in whom maxillary protrusion with vertical maxillary excess was treated by moving the maxilla backward more than 4 mm. The postsurgical positions of the maxilla were more posterior than the presurgical expectations, but the differences were within 1 mm. Cephalometric analysis revealed that the differences in each measurement between immediately and one year after surgery were within 1 degree. Without mandibular osteotomy, maxillary protrusion can be satisfactorily treated with Le Fort Ⅰ osteotomy alone.
著者
豊福 明
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.55, no.4, pp.163-168, 2009-04-20 (Released:2012-08-28)
参考文献数
25
被引用文献数
1 1

In dry mouth clinic, there are many patients who complained of subjective feelings of dry mouth despite their normal salivation. This dry mouth frequently comorbid with glossodynia or oral dysaesthesia. So far, these complaints have been thought to be ‘psychogenic’. Namely, psychosocial factors and/or individual factors have long been considered as main cause. Even if oral surgeons referred patients to psychiatry clinic, a majority of them wished to avoid consultation, or, would sometimes complain that the dry mouth got worse after medication. Therefore, it is very important and difficult problems for clinical oral surgeons to see how look at these patients and to learn how cope with them.From my own years of experience in psychosomatic studies, I think ‘distorted cognition ’ is central to these pathogenesis. These distorted cognition cause dissociations between subjective and objective findings. Moreover, I have propose a hypothesis that neurochemical dysfunction of some sort of neurotransmitter systems and distortions of information-processing in cerebral association area related to thought and memory underlie the distorted cognition.Patients with subjective dry mouth never tell a lie about their symptoms, but they have just ‘ neural network error’ in their brain. We should take up to problems of oral discomfort at the root of their complaint.If we suspect their complaints as the cause of psychogenic, it might be often unsuccessful in treatment. First of all, to listen carefully to complaints from them is very important, and then we have to do differential diagnosis. If patients are diagnosed the symptom form with distorted cognition, medication using SSRI or SNRI is necessary for reconstruction of impaired neuronal network. Of course oral surgeons have to receive advanced education and training to use psychotropic drugs. At the same time, it is needed for sensitive response to patients and family members.The distorted cognition with these patients are associated with dysfunction of neurotransmitter systems and information-processing in peripheral to higher central nervous system. Strange complaints and persistent therapeutic demand are representatives of the distorted cognition. If we regard queer complaints as neural network errors, we can see the psychogenic complaints as distorted cognition.At present, this hypothesis cannot be shown objectively, but it might be possible that some new approaches such as brain imaging make mechanisms of the distorted cognition more clear. It is very important to collect evidence-based diagnosis, therapies and pathophysiological mechanism for dry mouth as an oral psychosomatic disorder.
著者
河野 峰 柴田 敏之 永易 裕樹 北所 弘行 中田 大地 有末 眞
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.44, no.1, pp.16-21, 1998-01-20 (Released:2011-07-25)
参考文献数
13

We studied whether epidermal growth factor (EGF) enhances the motility of human oral squamous cell carcinoma (SCC) cells in an autocrine manner. The motility of five SCC cell lines (SAS, Ca 9-22, HSC-2, -3, -4) was examined with the use of a phagokinetic track assay. The motility of SAS cells and HSC-2 cells was significantly increased without EGF stimulation as compared with the three other cell lines. Amounts of EGF in the culture supernatants of the five cell lines after 48h of culture were examined with the immunoblotting method. EGF was detected in the supernatants of SAS cells and HSC-2 cells (SAS, 8.65±0.45; HSC-2, 2.60±1.13ng/ml). SAS cells, showing the highest levels of motility and EGF production, was used for further study. When SAS cells were treated with anti-EGF antibody, anti-EGF receptor antibody, and erbstatin analog, the motility of SAS cells was significantly inhibited. Furthermore, the culture supernatant of SAS cells enhanced the motility of HSC-3 cells in a concentration-dependent fashion. These results suggest that EGF may stimulate the motility of human oral SCC cells in an autocrine manner.
著者
林 良夫
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.57, no.5, pp.234-237, 2011-05-20 (Released:2014-05-22)
参考文献数
8

Primary Sjören’s syndrome (SS) is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lacrimal glands, leading to clinical symptoms of dryness of the mouth and eyes. Autoreactive T cells bearing CD4 molecule may recognize unknown self antigen, triggering autoimmunity in the salivary and lacrimal glands. Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T cells to tissue-specific self antigen including 120KD α-fodrin, and may drive the autoimmune phenomenon. Cleavage of certain autoantigens during apoptosis may reveal immunocryptic epitopes that could potentially induce autoimmune response. It is now evident that the interaction of Fas with FasL regulates a large number of pathophysiological process of apoptosis including autoimmune diseases. Our data imply that tissue-specific apoptosis and caspase-mediated α-fodrin proteolysis are involved in the progression of autoimmune lesions in SS. We found that retinoblastoma-associated protein RbAp48 overexpression induces apoptosis in the salivary glands caused by estrogen deficiency. The studies reviewed the pathology and molecular mechanisms on the development of SS.