著者
川田 賢介 河原 正和 秋森 俊行 山口 朋子 岡本 喜之 石川 好美
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.54, no.7, pp.423-426, 2008-07-20 (Released:2011-04-22)
参考文献数
23
被引用文献数
1 or 0

Oral mucosal lesions associated with foreign body injuries can have various origins, but traumatic lesions of the oral mucosa caused by other organisms are rare. Such cases thus require special knowledge for diagnosis. We report a case of oral stings from spermatophores of Todarodes pacificus, the Pacific squid. The patient was a 31-year-old woman who cooked the internal organs of a raw T. pacificus for lunch. She experienced a sharp pain on the tongue and buccal mucosa when eating the organs. On checking the oral cavity, she identified multiple white objects with a worm-like appearance sticking into the tongue and oral mucosa. Attempts to remove these objects herself were unsuccessful. She then visited the emergency department of our hospital. We examined the oral cavity and found multiple white objects appearing to be parasitic worms sticking into the tongue and oral mucosa. Attempts to remove the objects with forceps were unsuccessful because of tight attachment to the mucosa. Removal was thus achieved by making slight incisions under local anesthesia. The specimens showed a white spinate shape and were about 4mm long. Endoscopic examination of the upper digestive tract after treatment of the oral cavity revealed no additional foreign bodies. The final pathological diagnosis was spermatophores of T. pacificus.
著者
下村 忠弘 山本 一彦 栗原 都 柳生 貴裕 高野 梨沙 桐田 忠昭
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.58, no.10, pp.600-603, 2012-10-20 (Released:2014-11-20)
参考文献数
18

A case of sting wounds of the oral mucosa caused by spermatophores of a raw squid is reported. The patient was a 61-year-old woman. She noticed pain of the oral mucosa immediately after eating part of a raw squid. Several milky white, club-shaped foreign bodies measuring 3 to 5 mm were stuck in the tongue, buccal mucosa, and floor of the mouth. These were not mobile and were hard to remove. The clinical diagnosis was sting wounds of the oral mucosa caused by spermatophores of a squid. These foreign bodies were excised together with the surrounding tissue under local anesthesia. Wound healing was uneventful. Histologically, the foreign bodies contained numerous spermatozoa and were identified as spermatothecae, which were ejected from the spermatophores of a raw squid.
著者
木下 靖朗 冨田 陽二 早瀬 智広 中野 稔也
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.39, no.9, pp.993-995, 1993-09-20 (Released:2011-07-25)
参考文献数
13

This report presents rate two cases of foreign bodies (sperm-bags of squid) in the oral cavity, which were found in a 38-year-old male and 49-year-old female.Several small thorn-shaped foreign bodies stuck in the oral mucosa were observed and removed successfully.
著者
渋谷 恭之
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.6, pp.346-351, 2010-06-20 (Released:2013-10-19)
参考文献数
14

The current foundation of preventing nosocomial infection in dental settings are “Guidelines for infection control in dental health-care settings” announced in 2003 by Centers for Disease Control and Prevention (CDC). These guidelines employ a concept of standard precaution in clinical dentistry, and had a great influence on “Guideline for infection control in dental prosthetics” established in 2007 by Japan Prosthodontic Society and “Guideline for infection control in dentistry” announced by the dental division of the infection control conference of the national university hospitals in 2008. On the other hand, there have been many reports about oral care, for instance, ‘1) oral care prevents aspiration-related pneumonia', ‘2) oral care decreases the onset rate of the influenza to a one-tenth, (oral care decreases significantly neuraminidase and protease which bacteria produce) ', ‘3) oral care reduces a side effect in the oral cavity by the chemoradiotherapy', ‘4) oral care prevents ventilator-associated pneumonia in ICU', ‘5) oral care is useful for symptom relief in terminal illness', and an importance of oral care has been widely noticed in late years.
著者
前田 初彦
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.8, pp.464-470, 2010-08-20 (Released:2013-10-31)
参考文献数
36

In humans over 120 human papillomavirus (HPV) types have been completely described. HPVs have also been classified as low and high risk HPV types based on the clinical behavior of the HPV infected tissues. HPV proteins, especially the oncoproteins E6 and E7 of the oncogenic HPVs, interact with different degrees of affinity, with host cell proteins to disturb the normal epithelial differentiation and apoptosis by stimulating cellular proliferation, DNA synthesis and inhibition of cell cycle regulators. The best characterized interactions so far are the interactions between E7 and pRb and E6 and p53. Continued and aberrant expression of the E6 and E7 genes of the high risk HPVs will lead to genomic instability which finally after accumulation of mutational events can result in malignant transformation. Persistent infection with high risk HPV increase the risk of squamous cell carcinoma, while the low risk HPV may be associated with benign lesions. Also, HPV infections can be detected in the oral cavity and HPVs have been described as being associated with malignant lesions, such as oral squamous cell carcinoma and with benign lesions such as leukoplakia and oral papilloma. It is suggested that oral mucosa might serve as a reservoir of HPVs. Now, an inoculation of vaccine preventing HPV infection is performed, and the result begins to appear for the prevention of the cervical cancer. In addition, an improvement in the state of oral hygiene decreases the rate of HPV infection, and indicated that oral care may be an effective way to prevent HPV infections. The present conditions and the future prospects of the prevention and the treatment of HPV infections in the oral region are reported.
著者
河野 峰 柴田 敏之 永易 裕樹 北所 弘行 中田 大地 有末 眞
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.44, no.1, pp.16-21, 1998-01-20 (Released:2011-07-25)
参考文献数
13

We studied whether epidermal growth factor (EGF) enhances the motility of human oral squamous cell carcinoma (SCC) cells in an autocrine manner. The motility of five SCC cell lines (SAS, Ca 9-22, HSC-2, -3, -4) was examined with the use of a phagokinetic track assay. The motility of SAS cells and HSC-2 cells was significantly increased without EGF stimulation as compared with the three other cell lines. Amounts of EGF in the culture supernatants of the five cell lines after 48h of culture were examined with the immunoblotting method. EGF was detected in the supernatants of SAS cells and HSC-2 cells (SAS, 8.65±0.45; HSC-2, 2.60±1.13ng/ml). SAS cells, showing the highest levels of motility and EGF production, was used for further study. When SAS cells were treated with anti-EGF antibody, anti-EGF receptor antibody, and erbstatin analog, the motility of SAS cells was significantly inhibited. Furthermore, the culture supernatant of SAS cells enhanced the motility of HSC-3 cells in a concentration-dependent fashion. These results suggest that EGF may stimulate the motility of human oral SCC cells in an autocrine manner.
著者
林 良夫
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.57, no.5, pp.234-237, 2011-05-20 (Released:2014-05-22)
参考文献数
8

Primary Sjören’s syndrome (SS) is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lacrimal glands, leading to clinical symptoms of dryness of the mouth and eyes. Autoreactive T cells bearing CD4 molecule may recognize unknown self antigen, triggering autoimmunity in the salivary and lacrimal glands. Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T cells to tissue-specific self antigen including 120KD α-fodrin, and may drive the autoimmune phenomenon. Cleavage of certain autoantigens during apoptosis may reveal immunocryptic epitopes that could potentially induce autoimmune response. It is now evident that the interaction of Fas with FasL regulates a large number of pathophysiological process of apoptosis including autoimmune diseases. Our data imply that tissue-specific apoptosis and caspase-mediated α-fodrin proteolysis are involved in the progression of autoimmune lesions in SS. We found that retinoblastoma-associated protein RbAp48 overexpression induces apoptosis in the salivary glands caused by estrogen deficiency. The studies reviewed the pathology and molecular mechanisms on the development of SS.
著者
土屋 欣之 野口 忠秀 篠崎 泰久 伊藤 弘人 神部 芳則 草間 幹夫
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.58, no.2, pp.67-71, 2012

A case of orbital abscess with gas gangrene due to odontogenic infection is reported. Although orbital abscesses are rare, they may result in fatal complications. A 68-year-old woman presented with pain and swelling of the left cheek and lower eyelid. She was unable to open her left eye. Oral examination revealed alveolar gingival swelling due to a periapical lesion of the left upper anterior tooth. Computed tomographic scans confirmed abscess formation in the left orbit and the presence of a gas bubble. The ocular tension was 50 mmHg. On admission to our hospital, the patient started to receive antibiotics (PAPM/BP and CLDM), the left lower eyelid was incised, and the abscess was successfully drained. <i>Alpha-streptococcus</i>, <i>coagulase-negative staphylococcus</i>, and <i>Prevotella melaniogenica</i> were detected in the suppuration. The patient was given a diagnosis of orbital abscess with gas gangrene due to odontogenic infection extending by way of the orbit.
著者
山田 利治 河原 康 佐野 大輔 渡邉 裕之 小澤 総喜 神谷 祐司
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.54, no.4, pp.248-252, 2008-04-20
参考文献数
16
被引用文献数
2 or 0

We report a rare case of brain abscess secondary to mandibular odontogenic infection. A 50-year-oldman developed an abscess of the infratemporal fossa, masticatory myositis, and temporal myositis caused bylower first molar marginal periodontitis. Incision and drainage were performed by an intraoral approach, andantibiotics were administered intravenously. On the 8th disease day, vomiting occurred, but responded to anantiemetic drug. On the 9th disease day, extraction of lower first molar and adrasion was performed, resulting inthe alleviation of local symptoms. However, a persistent headache occurred, CT and MRI scans revealed a brainabscess and subdural abscess in the temporal lobe, immediately above the skull internal base. The patient wasgiven a diagnosis of brain abscess caused by odontogenic infection. The abscess almost disappeared after conservativetherapy administered at the department of brain surgery, and no sequelae were noted. The abscess apparentlyexpanded directly and continuously from the skull base through the foramen ovale and foramen spinosum.This case emphasizes the need to diagnose brain abscess and subdural abscess as complications of odontogenicinfection.
著者
新美 直哉 重冨 俊雄 大野 雄弘 小田 有紀子 水谷 英樹 上田 実
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.47, no.2, pp.144-147, 2001-02-20
被引用文献数
5 or 0

Amyloid is defined as a pathologic fibrous proteinaceous substance which, when deposited between the cells of tissues and organs, leads to various clinical conditions. Immunohistochemistry has allowed for better classification and understanding of the pathophysiology of amyloidosis.<BR>A 70-year-old man was referred to our department because of spontaneous purpura of the skin and hematoma of the oral mucosa. There was no chemical or hematologic abnormality on routine examination. Bence Jones protein was positive in the urine. Bone marrow examination, however, revealed an slightly increased proportion of plasma cells. It was unlikely that the Bence Jones protein was associated with multiple myeloma. Skin biopsy revealed depositions of amyloid, and Congo red stain for amyloid was positive. In addition, immunofluoroecent staining resulted in a diagnosis of AA amyloidosis.<BR>The patient was treated with a combination of colchicine, melphalan, and prednisolone; however, 7 months after initial presentation he died of cardiac failure. Autopsy revealed multiple-organ vascular amyloidosis, and a diagnosis of bullous amyloidosis was made.
著者
久保田 健稔 足立 忠文 山﨑 勝己 小川 倫子 濱田 傑
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.55, no.5, pp.236-240, 2009-05-20 (Released:2012-08-28)
参考文献数
21

We report a rare case of rhinogenous optic neuritis(RON)that was induced by odontogenic maxillarysinusitis in a 34-year-old woman. The patient was referred to our hospital because of visual disturbance of the left eye, gradually developing over the course of 1 month. On presentation to the Department of Ophthalmology, the corrected visual acuity and central critical flicker frequency of the affected left eye was 1.0 and 24Hz, respectively (1.2 and 45 Hz for the right eye). The left eye also showed paracentral scotoma. Computed tomography and magnetic resonance imaging revealed left sphenoid and maxillary sinus opacification, which indicated thickening of these sinus membranes. For a clinical diagnosis of RON in the left eye, a otolaryngologist performed endonasalsphenoid and maxillary sinusotomy under general anesthesia. After sinusotomy the patient came to our department for further evaluation. A panoramic radiograph showed projection of root canal filling material to the left maxillary sinus from the apex of the left maxillary second premolar. We extracted this tooth and the projecting material. Visual symptoms completely resolved 3 months after diagnosis by collaboration among the patient’s ophthalmologist, otolaryngologist, and oral and maxillofacial surgeon.
著者
Masashi SHIMAHARA Yasunori ARIYOSHI Yutaka IMAI Harumi MIZUKI Jun SHIMADA Kiyofumi FURUSAWA Syosuke MORITA Yoshiya UEYAMA
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
Japanese Journal of Oral and Maxillofacial Surgery (ISSN:00215163)
巻号頁・発行日
vol.53, no.10, pp.594-602, 2007-10-20 (Released:2011-04-22)
参考文献数
20
被引用文献数
13 or 0

Bisphosphonates are used for the management of bone metastatic disease and hypercalcemia caused by malignancy, as well as the treatment of osteoporosis. Recently, a number of patients with bisphosphonate-associated osteomyelitis and osteonecrosis of the jaws have been reported in the English-language literature. This report describes patients with bisphosphonate-related osteomyelitis and osteonecrosis of the jaws in Japan. The subjects were enrolled using questionnaires sent to 239 institutions certified as training facilities by the Japanese Society of Oral and Maxillofacial Surgeons in 2006. Thirty patients (4 men and 26 women) from 18 different institutions (mean age at diagnosis, 66.9 years) were studied. As for local features, pain with or without swelling was the most common symptom and sign. The mandible was affected in 22 patients, the maxilla in 6, and both jaws in 2. Twenty patients received intravenous bisphosphonates, 8 received only oral bisphosphonates, and 1 received both types of treatment. The reasons for bisphosphonate treatment were bone metastasis from breast carcinoma (13 patients), multiple myelomas (6 patients), osteoporosis (8 patients), and hypercalcemia related to malignancy. More than 50 % of the patients underwent oral surgery including tooth extraction just before or during treatment with bisphosphonates, while 5 patients received no dental treatment. In addition to antibiotic therapy, surgery, including sequestrectomy and curettage, was performed. As for outcome, 8 of the patients were completely cured, while 17 patients remained under treatment at the time of this writing.
著者
豊福 明
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.55, no.4, pp.163-168, 2009-04-20 (Released:2012-08-28)
参考文献数
25
被引用文献数
1 or 0

In dry mouth clinic, there are many patients who complained of subjective feelings of dry mouth despite their normal salivation. This dry mouth frequently comorbid with glossodynia or oral dysaesthesia. So far, these complaints have been thought to be ‘psychogenic’. Namely, psychosocial factors and/or individual factors have long been considered as main cause. Even if oral surgeons referred patients to psychiatry clinic, a majority of them wished to avoid consultation, or, would sometimes complain that the dry mouth got worse after medication. Therefore, it is very important and difficult problems for clinical oral surgeons to see how look at these patients and to learn how cope with them.From my own years of experience in psychosomatic studies, I think ‘distorted cognition ’ is central to these pathogenesis. These distorted cognition cause dissociations between subjective and objective findings. Moreover, I have propose a hypothesis that neurochemical dysfunction of some sort of neurotransmitter systems and distortions of information-processing in cerebral association area related to thought and memory underlie the distorted cognition.Patients with subjective dry mouth never tell a lie about their symptoms, but they have just ‘ neural network error’ in their brain. We should take up to problems of oral discomfort at the root of their complaint.If we suspect their complaints as the cause of psychogenic, it might be often unsuccessful in treatment. First of all, to listen carefully to complaints from them is very important, and then we have to do differential diagnosis. If patients are diagnosed the symptom form with distorted cognition, medication using SSRI or SNRI is necessary for reconstruction of impaired neuronal network. Of course oral surgeons have to receive advanced education and training to use psychotropic drugs. At the same time, it is needed for sensitive response to patients and family members.The distorted cognition with these patients are associated with dysfunction of neurotransmitter systems and information-processing in peripheral to higher central nervous system. Strange complaints and persistent therapeutic demand are representatives of the distorted cognition. If we regard queer complaints as neural network errors, we can see the psychogenic complaints as distorted cognition.At present, this hypothesis cannot be shown objectively, but it might be possible that some new approaches such as brain imaging make mechanisms of the distorted cognition more clear. It is very important to collect evidence-based diagnosis, therapies and pathophysiological mechanism for dry mouth as an oral psychosomatic disorder.
著者
有岡 将基 佐々木 匡理 石井 広太郎 金本 政樹 山城 崇裕 森 悦秀
出版者
社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.63, no.1, pp.15-20, 2017-01-20 (Released:2017-03-21)
参考文献数
21

Arsenic trioxide used to be used as an effective endodontic treatment. However, domestic production of arsenic trioxide for mortal pulpectomy was discontinued in 2005, because it is a toxic agent that has the risk of injuring periodontal tissues. We report a case of mandibular osteonecrosis caused by leakage of arsenic trioxide in a child after 2005. The patient was a 6-year-old boy who presented with swelling of the right buccal region, after arsenic trioxide had been used for mortal pulpectomy in the mandibular right second primary molar. The condition was diagnosed as mandibular osteonecrosis. The mandibular right first primary molar and mandibular right second permanent premolar were extracted, and a sequestrectomy was performed with the patient under local anesthesia. We still should consider that leakage of pulp devitalizing agents can cause osteonecrosis.
著者
松田 耕策 手島 貞一
出版者
Japanese Society of Oral and Maxillofacial Surgeons
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.39, no.12, pp.1350-1352, 1993
被引用文献数
3 or 0

Cancer occuring in the dorsum of the tongue is very rare. Several reports indicate that the rate of cancer occurrence in the dorsal tongue ranges from 2.8% to 7.2 % of all tongue cancer.<BR>In our clinic, there has been only one case of dorsal tongue cancer among 89 cases of tongue cancer from 1979 to 1992.<BR>The patient was a 68-year-old male who visited our clinic with a chief complaint of a tumor mass in the left dorsum of the tongue in November 1983.<BR>The tumor was a round, circumscribed, raised, and centrally depressed mass with a red surface. It was 15 mm in diameter and elastic but firm in consistency.<BR>Macroscopically, the tumor was doughnut-shaped.<BR>Pathologically, the tumor was diagnosed to be a squamous cell carcinoma.<BR>He was treated by intraoral electron therapy, one time (10 Gy) per week. The total dose amounted to 40 Gy. Clinically and pathologically, the tumor disappeared at that time.<BR>Nine years after intraoral electron therapy, he is still alive without primary recurrence or distant metastasis.