著者

下村 忠弘 山本 一彦 栗原 都 柳生 貴裕 高野 梨沙 桐田 忠昭

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.58, no.10, pp.600-603, 2012-10-20 (Released:2014-11-20)

参考文献数

18

被引用文献数

2

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A case of sting wounds of the oral mucosa caused by spermatophores of a raw squid is reported. The patient was a 61-year-old woman. She noticed pain of the oral mucosa immediately after eating part of a raw squid. Several milky white, club-shaped foreign bodies measuring 3 to 5 mm were stuck in the tongue, buccal mucosa, and floor of the mouth. These were not mobile and were hard to remove. The clinical diagnosis was sting wounds of the oral mucosa caused by spermatophores of a squid. These foreign bodies were excised together with the surrounding tissue under local anesthesia. Wound healing was uneventful. Histologically, the foreign bodies contained numerous spermatozoa and were identified as spermatothecae, which were ejected from the spermatophores of a raw squid.

著者

木下 靖朗 冨田 陽二 早瀬 智広 中野 稔也

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.39, no.9, pp.993-995, 1993-09-20 (Released:2011-07-25)

参考文献数

13

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This report presents rate two cases of foreign bodies (sperm-bags of squid) in the oral cavity, which were found in a 38-year-old male and 49-year-old female.Several small thorn-shaped foreign bodies stuck in the oral mucosa were observed and removed successfully.

著者

川口 泰 高橋 浩師 八反田 麻衣 野谷 健一

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.63, no.5, pp.271-275, 2017-05-20 (Released:2017-07-20)

参考文献数

20

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We report a case of tooth loss and alveolar bone necrosis secondary to herpes zoster in the region innervated by the third branch of the trigeminal nerve. The patient was a 74-year-old man who was referred to our department with chief complaints of tooth loss and exposure of the alveolar bone in the left mandible. He had a history of herpes zoster of the trigeminal nerve and had spontaneous loss of the left mandibular second premolar and first molar approximately 2.5 months and 1.5 months before his first visit, respectively. Initial examination revealed exposure of the alveolar bone of the two affected teeth, with gingival swelling and flare. In addition, paresthesia was present in the region innervated by the third branch of the left trigeminal nerve, for which a dermatologist had prescribed vitamin B12. Antibacterial treatment with local irrigation was performed after initial presentation. Five weeks after his first visit, we observed the elimination of a sequestrum. Currently, the exposed bone has disappeared, and the patient's disease course has been uneventful. The pathological diagnosis was bone necrosis associated with infection.

著者

樋口 景介 千葉 雅俊 高橋 哲 越後 成志

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.59, no.2, pp.98-102, 2013-02-20 (Released:2014-11-29)

参考文献数

14

被引用文献数

1

---

We report two cases of alveolar osteonecrosis and tooth loss caused by trigeminal herpes zoster infection.A 69-year-old man and a 73-year-old man were referred to our hospital after the onset of herpes zoster infection of the third ramus of the right trigeminal nerve. The first patient had alveolar osteonecrosis and spontaneous teeth exfoliation (5 4 3) 15 days after the onset of herpes zoster infection. He was given a diagnosis of mandibular carcinoma by his dentist. The second patient had teeth mobility (4 3) 4 days after the onset of herpes zoster infection. He was given a diagnosis of acute necrotizing ulcerative gingivitis by his dentist. In both patients antibiotic therapy and local irrigation were performed, and the separated necrotic bone was removed step by step. In the second patient the right lower canine, which had grade III tooth mobility, was extracted 55 days after treatment. After final removal of the necrotic bone, cure was obtained.Although both patients showed a typical clinical course of herpes zoster infection, their dentists could not make a correct diagnosis. Therefore it is necessary to be aware that alveolar osteonecrosis and tooth loss can be caused by trigeminal herpes zoster infection. Minimum surgical treatment may be effective for such complications.

著者

川田 賢介 河原 正和 秋森 俊行 山口 朋子 岡本 喜之 石川 好美

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.54, no.7, pp.423-426, 2008-07-20

参考文献数

23

被引用文献数

2 2

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Oral mucosal lesions associated with foreign body injuries can have various origins, but traumatic lesions of the oral mucosa caused by other organisms are rare. Such cases thus require special knowledge for diagnosis. We report a case of oral stings from spermatophores of <I>Todarodes pacificus</I>, the Pacific squid. The patient was a 31-year-old woman who cooked the internal organs of a raw <I>T. pacificus</I> for lunch. She experienced a sharp pain on the tongue and buccal mucosa when eating the organs. On checking the oral cavity, she identified multiple white objects with a worm-like appearance sticking into the tongue and oral mucosa. Attempts to remove these objects herself were unsuccessful. She then visited the emergency department of our hospital. We examined the oral cavity and found multiple white objects appearing to be parasitic worms sticking into the tongue and oral mucosa. Attempts to remove the objects with forceps were unsuccessful because of tight attachment to the mucosa. Removal was thus achieved by making slight incisions under local anesthesia. The specimens showed a white spinate shape and were about 4mm long. Endoscopic examination of the upper digestive tract after treatment of the oral cavity revealed no additional foreign bodies. The final pathological diagnosis was spermatophores of <I>T. pacificus</I>.

著者

前田 初彦

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.56, no.8, pp.464-470, 2010-08-20 (Released:2013-10-31)

参考文献数

36

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In humans over 120 human papillomavirus (HPV) types have been completely described. HPVs have also been classified as low and high risk HPV types based on the clinical behavior of the HPV infected tissues. HPV proteins, especially the oncoproteins E6 and E7 of the oncogenic HPVs, interact with different degrees of affinity, with host cell proteins to disturb the normal epithelial differentiation and apoptosis by stimulating cellular proliferation, DNA synthesis and inhibition of cell cycle regulators. The best characterized interactions so far are the interactions between E7 and pRb and E6 and p53. Continued and aberrant expression of the E6 and E7 genes of the high risk HPVs will lead to genomic instability which finally after accumulation of mutational events can result in malignant transformation. Persistent infection with high risk HPV increase the risk of squamous cell carcinoma, while the low risk HPV may be associated with benign lesions. Also, HPV infections can be detected in the oral cavity and HPVs have been described as being associated with malignant lesions, such as oral squamous cell carcinoma and with benign lesions such as leukoplakia and oral papilloma. It is suggested that oral mucosa might serve as a reservoir of HPVs. Now, an inoculation of vaccine preventing HPV infection is performed, and the result begins to appear for the prevention of the cervical cancer. In addition, an improvement in the state of oral hygiene decreases the rate of HPV infection, and indicated that oral care may be an effective way to prevent HPV infections. The present conditions and the future prospects of the prevention and the treatment of HPV infections in the oral region are reported.

著者

桐澤 知子 森家 祥行 松本 聖武 森岡 慶一

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.59, no.9, pp.598-602, 2013-09-20 (Released:2014-12-13)

参考文献数

22

被引用文献数

1

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We report a case of allergic contact stomatitis extensively affecting the oral mucosa that was caused by eating grated Japanese radish for several months. A 39-year-old woman was referred to our hospital because of an eating disorder due to stomatitis. She received supplementary liquid treatment after hospitalization. The symptoms improved, and she was discharged. However, she was readmitted because stomatitis recurred extensively after eating grated Japanese radish. Contact stomatitis or oral allergy syndrome was suspected. We therefore performed blood tests, patch testing, and provocative tests. The results of a skin patch test was positive, and stomatitis developed after several hours on provocative testing. We advised her to completely avoid eating grated Japanese radish. She was discharged after stomatitis had improved. Subsequently, stomatitis has not recurred because she has avoided eating grated Japanese radish.

著者

浅田 泰幸 下里 剛史 齋藤 翔太 町田 好聡 渡邊 裕加 山本 学

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.64, no.5, pp.302-306, 2018-05-20 (Released:2018-07-20)

参考文献数

21

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Human myiasis is a parasitic infestation caused by fly larvae. There are many case reports of parasitic infestations in the digestive tract, ears, and sites of traumatic injury, but few reports of infestation inside the oral cavity. We report a case of human myiasis arising in the anterior maxillary gingiva. A 91-year-old woman was admitted to our hospital in October 2016 because of pneumonia. She started to receive antimicrobials after being hospitalized and her pneumonia symptoms were resolving, when five larvae were observed in the maxillary gingiva during oral care on hospital day 19. The larvae were extracted and sent to Japan’s National Institute of Infectious Diseases (Ministry of Health, Labour, and Welfare) for identification. They were identified as the third instar larvae of Sarcophaga similis. Based on the growth cycle of Sarcophaga similis, our patient is believed to have contracted the infestation after hospitalization. Regular, strict oral care was provided, and no insect larvae were found thereafter. Her pneumonia and oral health status improved, and she was transferred to another hospital on hospital day 35.

著者

渋谷 恭之

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.56, no.6, pp.346-351, 2010-06-20 (Released:2013-10-19)

参考文献数

14

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The current foundation of preventing nosocomial infection in dental settings are “Guidelines for infection control in dental health-care settings” announced in 2003 by Centers for Disease Control and Prevention (CDC). These guidelines employ a concept of standard precaution in clinical dentistry, and had a great influence on “Guideline for infection control in dental prosthetics” established in 2007 by Japan Prosthodontic Society and “Guideline for infection control in dentistry” announced by the dental division of the infection control conference of the national university hospitals in 2008. On the other hand, there have been many reports about oral care, for instance, ‘1) oral care prevents aspiration-related pneumonia', ‘2) oral care decreases the onset rate of the influenza to a one-tenth, (oral care decreases significantly neuraminidase and protease which bacteria produce) ', ‘3) oral care reduces a side effect in the oral cavity by the chemoradiotherapy', ‘4) oral care prevents ventilator-associated pneumonia in ICU', ‘5) oral care is useful for symptom relief in terminal illness', and an importance of oral care has been widely noticed in late years.

著者

浅香 卓哉 坂田 健一郎 竹川 英輝 羽藤 裕之 鎌口 真由美 大賀 則孝 佐藤 淳 山崎 裕 北川 善政

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.65, no.8, pp.500-506, 2019-08-20 (Released:2019-10-21)

参考文献数

28

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Glossodynia is defined as a burning sensation on the tongue without any systemic or local cause. Although its pathophysiology remains unclear, it has been associated with neuropathic, nociceptive, and psychogenic pains. In Japan, difficulties are encountered in the treatment of glossodynia as prescribed medications are not covered by health insurance. Recently, a traditional Chinese medicine treatment (kampo), rikko-san (TJ-110), has been suggested to be useful for glossodynia. The objective of this retrospective study was to evaluate the efficacy of rikko-san gargling in patients with glossodynia. In total, 221 patients with glossodynia who were treated by rikko-san gargling between 2012 and 2018 were examined. Of these, 90 patients (seven men, 83 women; mean age, 67 years) who were treated by gargling with rikko-san dissolved in water for >1 month and no other medications were included. Tongue pain was assessed using a visual analog scale (VAS). Improvement was defined as at least a 50% reduction in the VAS score after treatment compared with that before treatment. The associations between the efficacy of rikko-san gargling and factors such as age, disease duration, pain area, and psychiatric disorders were evaluated. Improvement was noted in 60% of the patients (54/90) ; the mean administration period to the end of treatment in the improvement group was approximately 5 months. There was no significant correlation between the aforementioned factors and the efficacy of rikko-san gargling. Treatment in 41 patients was completed with rikko-san gargling alone, whereas 40 patients required additional treatment such as another kampo medicine or ethyl loflazepate. No side effect was observed in any patient, although stomatitis was noted in one excluded case. The mechanism underlying rikko-san’s delivery pathway is distinct from that of selective serotonin reuptake inhibitors, benzodiazepines, and nonsteroidal anti-inflammatory drugs. We speculated that saishin (Asiasarum root), one of the major components of rikko-san, may reduce peripheral stimulation to the tongue surface through its anesthetic effect. In addition, the transmucosal actions of other components in rikko-san may influence various receptor-related neuropathic pains. In conclusion, rikko-san gargling is efficacious and safe for the treatment of glossodynia.

著者

齊藤 昌樹 畑中 隆志 川口 拓郎 久馬 孝仁 長嶺 健二郎 澤木 佳弘

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.61, no.12, pp.667-672, 2015-12-20 (Released:2016-03-14)

参考文献数

34

被引用文献数

1 5

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Recently, methotrexate-associated lymphoproliferative disorders (MTX-LPD) in patients with rheumatoid arthritis (RA) have frequently been reported as a lymphoproliferative disorder developing in immunosuppressed patients. Many reports have indicated a relation between MTX-LPD and Epstein-Barr virus (EBV). We report 4 cases of EBV-positive MTX-LPD arising in the oral cavity. After consulting a hematologist, methotrexate (MTX) was discontinued in three patients, and one patient moved to another medical facility. Three lesions regressed after MTX withdrawal. However, one patient who resumed treatment with MTX had a relapse of LPD. A literature search on MTX-LPD in the oral cavity revealed a high positive rate of EBV, a good response to MTX withdrawal, a higher prevalence in women, and a high frequency of maxillary gum involvement.

著者

岩田 英治 古土井 春吾 鰐渕 聡 岸本 恵実 明石 昌也 古森 孝英

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.64, no.2, pp.83-87, 2018-02-20 (Released:2018-04-20)

参考文献数

17

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Osteonecrosis of the jaw is one of the problematic side effects observed during administration of angiogenesis inhibitors in patients receiving treatment for cancer. We report a case of osteonecrosis of the jaw in a patient receiving sunitinib. The patient was a 72-year-old man who was referred to our hospital because of exposed bone and contact pain of the tongue. After the clinical diagnosis of osteonecrosis of the jaw, observation and irrigation of the exposed bone were frequently performed. Four months later, the lesion healed. After 1 year, exposed bone was found in other sites ; however, it disappeared a month later. The present case suggests that the use of sunitinib can be associated with osteonecrosis of the jaw and indicates that invasive dental treatment and the status of the main disease should be considered when prescribing sunitinib, as is done when prescribing bisphosphonates or denosumab.

著者

奥田 克爾

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.56, no.4, pp.231-239, 2010-04-20 (Released:2013-10-19)

参考文献数

29

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Oral biofilm-forming bacteria consist of a dense bacterial mass tightly adhering to the surface of the oral cavity. The characteristics of dental biofilm are resistant against not only host defense mechanisms but also various antimicrobial agents. The predominant bacteria forming biofilm result in persistent infection. The proteolytic enzymes, exotoxins, endotoxins, and HSPs of these bacteria play a significant role in the development of oral infectious disease and affect systemic condition.We detected DNA and antigen of Treponema denticola in atherosclerotic lesions, and also found that the 16S rRNAs of Porphyromonas gingivalis, Aggregatibacter (formally Actinobacillus) actinomycetemcomitans,Tannerella forsythia, T. denticola, and Campylobacter rectus in samples of stenotic coronary arterial plaque. We showed the invasive activity of these bacteria into human vein endothelial cells. Increasing evidence has linked the dental biofilm with respiratory infectious diseases such as aspiration pneumonia in elderly persons. We investigated the effects of oral health care for elderly persons requiring nursing care on prevention of influenza infection.In the oral care group, colony-forming cell number, neuraminidase and trypsin-like protease activities in saliva decreased. It was found that one of 98 patients was diagnosed with influenza; whereas, in the non-oral care group,nine of 92 patients were diagnosed with influenza. The finding indicates that oral hygiene is one of the effective strategies to prevent influenza infection. Periodontal surrounding cells such as macrophage possessing TLRs and CD14 that are endotoxin binding protein. Carrying endotoxin with macrophage to various tissues releases inflammatory cytokines such as TNF-αand IL-1 that produce resistance to insulin sensitivity and cause obesity and diabetes. An attempt to discover new things by studying the past through scrutiny of old, there are many evidences on the close relationship between the primary dental biofilm infectious diseases and secondly systemic diseases such as nephritis, dermatitis and arthritis.The author firmly believes that control of oral biofilm-forming infectious diseases by the surgical treatment is an essential strategy and management of such systemic conditions.

著者

岩永 譲 古賀 千尋 加来 伸一郎 藤井 智津 岩本 修 楠川 仁悟

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.56, no.2, pp.95-97, 2010-02-20 (Released:2013-10-19)

参考文献数

9

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A case of oral mucosal ulcer caused by the inappropriate use of nicotine gum is reported.The patient was a 55-year-old man who was a heavy smoker. He had smoked 60 cigarettes a day for 36 years. He had been using nicotine gum as a "stop-smoking aid" for over 8 months. He was referred to our department because of an unhealed undermining ulcer at the mucogingival junction of the lower right anterior teeth. On exfoliative cytology, there were no atypical cells in a specimen of the ulcer. Therefore, we recommended him to stop using nicotine gum, which was inappropriately placed at the buccal vestibule of mouth. The tenderness then gradually improved, and the ulcer healed in the month. Long-term inappropriate use of nicotine gum can cause adverse effects to the oral mucosa.

著者

篠崎 昌一 森山 雅文 林田 淳之介 田中 昭彦 前原 隆 古川 祥子 太田 美穂 今林 佑美 中村 誠司

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.61, no.3, pp.147-153, 2015-03-20 (Released:2015-09-29)

参考文献数

13

被引用文献数

1

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Objectives: Cevimeline hydrochloride (CH) and pilocarpine hydrochloride (PH) are recognized as salivation-inducers with a high affinity for M3 muscarinic receptors. However, these drugs have a high frequency of side effects, including digestive symptoms and hyperhidrosis. We compared the effectiveness and side effects of these two drugs before and after a medication change.Materials and Methods: Seventy-six patients with Sjögren's syndrome were divided into the following four groups: 1) CH group, CH was administered for 12 months; 2) PH group, PH was administered for 12 months; 3) CH-PH group, CH was administered for 6 months followed by PH for 6 months; 4) PH-CH group, PH was administered for 6 months followed by CH for 6 months. We measured the salivary flow rate and recorded the subjective symptoms in each group.Results: In each group, stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) significantly increased after 3 months and 6 months, respectively, and subjective symptoms improved after 3 months. The incremental changes in both SWS and UWS did not differ significantly between the groups. The CH and PH groups both had digestive symptoms (32.3% and 32.1%, respectively) and hyperhidrosis (29.0% and 39.3%, respectively). We found no significant difference in salivary flow rate or subjective symptoms after the medication change. However, the frequencies of side effects in the CH-PH and PH-CH groups decreased significantly for both digestive symptoms (9.7% and 10.7%, respectively) and hyperhidrosis (25.8% and 14.3%, respectively).Conclusions: After changing the salivation-inducing drug, there was no significant difference in salivary function or subjective symptoms, while the frequency of side effects markedly decreased. These results suggest that changing the salivation-inducing drug effectively reduces side effects.

著者

三木 浩三 松村 智弘 森下 正明 難波 和之 木下 文夫

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.24, no.3, pp.549-552, 1978-06-15 (Released:2011-07-25)

参考文献数

9

被引用文献数

1

著者

住田 知樹 加藤 友美 吉村 友秀 村瀬 隆一 中城 公一 浜川 裕之

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.55, no.9, pp.463-466, 2009-09-25 (Released:2012-08-28)

参考文献数

14

被引用文献数

3 7

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Methotrexate (MTX) has been proven to be effective for the treatment of rheumatoid arthritis (RA)and is believed to be nononcogenic when a low weekly dose is administered to patients with RA. However, wereport the case of a 71-year-old man with RA who was treated for 11 years with MTX and developed B cell non-Hodgkin's lymphoma (BNHL) in the oral cavity. The tumor was localized in the right maxilla extranodally.Microscopic examination of a biopsy specimen revealed a non-epithelial tumor pattern and showed BNHL inwhich large cells with pleomorphic nuclei invaded the muscle tissue. These large cells tested strongly positive forEpstein-Barr virus encoded small RNAs-in situ hybridization (EBER-ISH) and CD20 antibody. We immediatelystopped MTX administration; however, only minimal shrinkage of the tumor was observed. Therefore, we performedantibody treatment with rituximab. After chemotherapy, complete remission was achieved. To date, thepatient is healthy, with no evidence of tumor recurrence during 32 months of follow-up. The development of anextranodal lymphoma in the oral cavity in a patient with RA who received MTX has not been reported previously.Therefore, this case is considered extremely rare.

著者

杉山 芳樹

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.60, no.5, pp.251, 2014

著者

高橋 祥一郎 後藤 昌昭 岡 増一郎 田代 英雄

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.25, no.5, pp.967-972, 1979-10-15 (Released:2011-07-25)

参考文献数

31

被引用文献数

1 2

著者

金丸 祥平 新垣 晋 芳澤 享子 西山 秀昌 程 珺 小林 正治

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.64, no.7, pp.423-428, 2018-07-20 (Released:2018-09-20)

参考文献数

21

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Sarcomatous transformation of fibrous dysplasia (FD) is an extremely rare event. We report a case of low-grade central osteosarcoma (LGCO), which arose secondarily from FD of the mandible. A 35-year-old woman, who had regularly been followed up for a 19-year period for a diagnosis of FD, presented with a painful swelling in right mandibular body. On computed tomographic images, the right mental area was prominently expanded with the eroded cortex, and its inner part was entirely filled with an inhomogeneously enhanced lesion. Since a biopsy specimen taken from the anterior lesion was diagnosed to be LGCO, a segmental mandibulectomy and reconstruction with a fibula free flap was performed. There has been no sign of recurrence or metastasis as of 7 years after surgery. It is important to make a diagnosis and a treatment plan in patients with FD because malignant transformation of FD occurs rather infrequently.