著者

朝比奈 菊雄 吉中 邦子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.73, no.5, pp.501-505, 1953-05-25 (Released:2010-02-19)

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Attempt was made to obtain homogeneous vitamin B1 tablets by the improvement of manufacturing processes from finding the cause of variations in content of vitamin B1. As a result it was experimentally confirmed that the following equation is establishedσr2=σw2+σc2+σm2+2ρ⋅σw⋅σcwhen σr, σω, σc and σw respectively stand for the observed value, weight, content per unit weight, and standard deviation of determined value, and ρ, the coefficient of interdependence. From these findings, improvements were made on the mixing and granulation processes. Examinations were also made on the thiochrome process for determination of vitamin B1, conditions for direct absorption determination, and interdependence.