著者

広瀬 仁宏 松本 修一 平松 哲夫 吉田 光伸 吉田 真子 高田 和外 星野 多美 岩田 晋

出版者

特定非営利活動法人 日本呼吸器内視鏡学会

雑誌

気管支学 (ISSN:02872137)

巻号頁・発行日

vol.22, no.2, 2000

著者

山崎 勤 小川 勝比古 山川 宗位 山中 昇 白戸 勝 柳内 統 吉田 真子 山本 一男 福田 勝洋

出版者

耳鼻と臨床会

雑誌

耳鼻と臨床 (ISSN:04477227)

巻号頁・発行日

vol.34, no.4, pp.987-1007, 1988-07-20 (Released:2013-05-10)

参考文献数

27

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The clinical effect of isosorbide (TYS) for patients with Ménière's disease was first reported in 1981. Long-term treatment by TYS produced considerable symptomatic relief in many patients during the active stage of the disease. In the present study, the effect of TYS for patients with Ménière's disease was evaluated by a multi-centered double blind trial using betahistine meyslate (MR) as a reference drug over a period of 8 weeks. The indices that reflect global improvement and utility showed, by the Wilcoxon rank sum test (one-tailed), that the TYS was significantly (P<0.05) superior to the MR in the effectiveness of the control of Ménière's disease at 2 weeks, 4 weeks, 6 weeks and 8weeks after administration. There was no particular difference in the frequencies of side effects or abnormal clinical laboratory findings between groups treated with TYS and with MR. From the above results, it was concluded that TYS was an effective and useful drug for the treatment of Ménière's disease.