著者

井上 功 山本 砧三 武嶋 寛剛 中小 路澄子 貞岡 達也 坂哲 郎 垣鍔 典也 坂倉 淳 牧本 一男 高橋 宏明 和田 公平 大森 研史 林 伊吹 藤田 隆夫 渡辺 猛世 藤澤 俊二 宇野 功 野中 隆三郎

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.87, no.7, pp.985-995, 1994-07-01 (Released:2011-11-04)

参考文献数

5

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The effectiveness, safety and usefulness of ketotifen nasal spray were investigated in 163 patients with allergic rhinitis. Ketotifen nasal spray (0.05mg/puff) was given four times daily for 4 weeks or more. “Slight to high” improvement was recorded in 92.4% of patients and “moderate to high” improvement in 61.0%.Overall usefulness was very high for both perennial and seasonal allergic rhinitis. Side effects were noted in six patients (3.7%). Drowsiness was noted in five patients and nasal mucosal pain in only one.The results of this study suggest that ketotifen nasal spray is very useful in the treatment of allergic rhinitis.

著者

大木 孝一 和田 公平 山本 祐三 牧本 一男 高橋 宏明

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.86, no.12, pp.1757-1762, 1993-12-01 (Released:2011-11-04)

参考文献数

6

被引用文献数

2 4

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Actinomycosis is a chronic purulent granulomatous disease caused by actinomyces, an organism which is often present in man. Patients with a chronic clinical course have been on the increase in recent years, and differentiating this disease from tumor is often necessary when the mass is in facial and cervical regions other than the oral cavity and jaw. We report two cases of actinomycosis in the face and neck.Case 1: A 54-year-old man complained of a swelling in the anterior part of the neck. A mass 65 × 70 mm with redness of the skin was noted at his first visit. The mass was of platelike consistency with a smooth surface closely adherent to the surrounding tissue. The tuberculin test was negative. A malignant tumor was considered, so percutaneous needle biopsy was performed, but no significant abnormality was found. Antibiotics were given by drip infusion, and the mass disintegrated. Yellow viscous pus containing light gray granules was discharged to form a fistula.Case 2: A 40-year-old man developed a swelling in the left cheek. A ping pong ball-sized mass of plate-like consistency with redness was noticed at his first visit. A fistula formed in the oral cavity on the left, and pus was discharged from it. Plain CT revealed an isodense lesion in the left cheek, with no connection to the maxillary sinus.Actinomyces is anaerobic, so it was not detected by culture in either case. Histopathological examinations of actinomycotic granules was useful in the diagnosis.The treatment consists mainly of drainage by incision of the lesion and administration of antibiotics, especially penicillin.