著者

和田 卓巳 廣中 謙一 黒田 真也

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.61, no.5, pp.288-292, 2021 (Released:2021-09-28)

参考文献数

16

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Organisms can adapt to the environment robustly despite large heterogeneity of cellular response. Heterogeneity of cellular responses has been regarded as noise, which reduces accurate information transmission. The heterogeneity consists of intracellular variation caused by stochasticity of biochemical reactions, and intercellular variation caused by differences in amounts of molecules (cell-to-cell variability). We found that intercellular variation increases gradualness of the multi-cellular dose-response (response diversity effect), resulting in increase of accuracy of information transmission. This “response diversity effect” is a novel mechanism that enables multi-cellular organisms to utilize cell-to-cell variability as information not noise.