著者

太田 紘也 喜多 紗斗美

出版者

徳島文理大学

雑誌

基盤研究(C)

巻号頁・発行日

2020-04-01

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マクロファージは一般的には炎症を誘導性と見做されるが、近年では抗炎症作用を示すマクロファージの存在が明らかになり、M2マクロファージと総称される。M2マクロファージは、がんやメタボリック症候群などの様々な病気の発症に関わることが明らかになり、マクロファージの分極化(M1/M2)を制御機構に関する研究が注目されている。本研究では、ミトコンドリアNa+/Ca2+交換輸送体(NCLX)がM2マクロファージで高発現することを踏まえ、ミトコンドリアのCa2+輸送体によるミトコンドリアのCa2+動態制御と、マクロファージの分極化および機能発現の関連性の解明を目指す。

著者

松村 靖夫 喜多 紗斗美 森本 史郎 秋元 健吾 古谷 真優美 岡 直美 田中 隆治

出版者

公益社団法人日本薬学会

雑誌

Biological & pharmaceutical bulletin (ISSN:09186158)

巻号頁・発行日

vol.18, no.7, pp.1016-1019, 1995-07-15

被引用文献数

18 93

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We investigated the antihypertensive effect of sesamin, a lignan from sesame oil, using deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The animals were unilaterally nephrectomized, and then separated into a sham-operated group (sham group) and a DOCA-salt-treated group. The latter was further separated into a normal diet group (control group) and a sesamin-containing diet group (sesamin group). The systolic blood pressure of control group progressively increased in comparison with that of sham group. This DOCA-salt-induced hypertension was markedly suppressed by feeding a sesamin-containing diet. Systolic blood pressure after 5 weeks was 130.6±1.9mmHg in the sham group, 198.1±7.3mmHg in the control group and 152.5±8.4mmHg in the sesamin group, respectively. The treatment with DOCA and salt for 5 weeks significantly increased the weight of the left ventricle plus the septum. However, this increase was signiflcantly suppressed in the sesamin group. When the degree of vascular hypertrophy of the aorta and superior mesenteric artery was histochemically evaluated, there were significant increases in wall thickness, wall area and the wall-to-lumen ratio in the control group, compared with the sham. Sesamin feeding ameliorated the development of DOCA-salt-induced vascular hypertrophy in both the aorta and mesenteric artery. These findings strongly suggest that sesamin is useful as a prophylactic treatment in the development of hypertension and cardiovascular hypertrophy.