- 著者
- 鈴木 宏一 平田 博明 猪飼 隆 坂田 五常
- 出版者
- 日本農薬学会
- 雑誌
- 日本農薬学会誌 (ISSN:03851559)
- 巻号頁・発行日
- vol.16, no.2, pp.p315-323, 1991
Quizalofop-ethyl, ethyl 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy] propionate is a selective grass herbicide developed by Nissan Chemical Industries, Ltd. Quizalofop-ethyl possesses a wide herbicidal spectrum for grass weeds with a quick action at low application rates by foliage applications. It shows good safety for non-gramineous crops. A research for a grass killer herbicide, focussed on heterocyclicoxy phenoxy proionic acid, began in 1978. During investigations on the various condensed heterocyclic moieties, the quinoxalinyloxy phenoxy propanoic acid derivatives were found to have a high potential for grass herbicides. Through the optimization of derivertives, the title compound was selected as a candidate for development. In field trials conducted in major producing areas of soybeans, cotton, sugar beet and other broad leaf crops, quizaolfop-ethyl demonstrated sufficient control at 0.5-1.5 g a.i./a for annual grass species and at 1.25-2.5 g a.i./a for perennial ones. Quizalofop-ethyl was translocated from treated leaves to meristem tissues of grass weeds within a day and attacks these parts, followed by causing necrosis. Quizalofop, which is the metabolite of quizalofop-ethyl, was proved to be a potent inhibitor of fatty acids synthesis through acetyl-CoA carboxylase inhibition. A main metabolic pathway of quizalofop-ethyl was the hydrolysis to quizalofop in plants, soil and mammals. Following hydrolysis, cleavages of ester bonds, hydroxylations and conjugation of quizalofop occurred. Toxicity of quizalofop-ethyl in mammals, fish and birds was very low. Its potential hazard to the environment was minimal.
- 著者
- 坂田 五常 牧野 健二 河村 保夫 猪飼 隆
- 出版者
- 日本農薬学会
- 雑誌
- 日本農薬学会誌 (ISSN:03851559)
- 巻号頁・発行日
- vol.10, no.1, pp.61-67, 1985-02-20
- 被引用文献数
- 1
Ethyl 2-[4-(6-chloro-2-quinoxalinyloxy) phenoxy]-propanoate (code No. NCI-96683)は, 現在日産化学工業(株)によって開発中の新しい選択性除草剤である.これまで数種のheterocyclicoxy phenoxy propanoic acid誘導体が選択性除草剤として知られていた.本研究においてヘテロ環としてさまざまなベンゼン縮合ヘテロ環を探索合成した結果, quinoxalinyloxy phenoxy propanoic acid誘導体, とくにNCI-96683がすぐれたイネ科雑草に対する除草活性と広葉作物選択性を示すことを見いだした.これらの誘導体は合成原料として2-chloroquinoxaline誘導体とhydroquinoneおよびα-halogenopropanoic acid誘導体を用いて合成した.NCI-96683は, 大豆, 棉, 甜菜, なたねなどの広葉作物に薬害を示すことなく, イヌビエ, メヒシバ, オヒシバ, エノコログサ, オオクサキビ, カラスムギおよびセイバンモロコシなどに卓効を示した.圃場試験においては, 一年生イネ科雑草に対し0.05-0.15 kg a.i./ha, 多年生イネ科雑草では0.11-0.22 kg a.i./haで十分な除草効果が得られた.