著者

城戸 克己 徳光 里弥 伊比禮 真希 福田 直通

出版者

第一薬科大学

雑誌

第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)

巻号頁・発行日

no.30, pp.89-97, 2014-03-31

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Cognitive deficits and behavioral and psychological symptoms of dementia(BPSD) are typical features of patients with dementia such as Alzheimer’s disease(AD), vascular dementia(VD), and other forms of senile dementia.Kampo medicine is used frequently against dementia. Orengedokuto and Chotosan are Kampo medicines that has been used clinically for the treatment of dementia.Clinical evidence has demonstrated the potential usefulness of Orengedokuto and Chotosan, in the treatment of cognitive disturbance and BPSD in dementia patients.In double-blind controlled study ,Chotosan was statistically superior to the placebo in global improvement rating, utility rating, global improvement rating of subjective symptoms, global improvement rating of psychiatric symptoms and global improvement rating of disturbance in daily living activities.Efficacy and safety of some campo medicines for dementia has reported.Kampo medicines for dementia is promising therapy which maintain QOL for patients and caregivers.In conclusion, Orengedokuto and Chotosan are useful option for the treatment of cognitive impairment in dementia.Further extensive studies need to be conducted to elucidate in more detail mechanisms.

著者

城戸 克己 徳永 浩二 宇都 愛 下村 由貴 土井 章義 中川 世也 森山 峰博 福田 直通

出版者

第一薬科大学

雑誌

第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)

巻号頁・発行日

no.28, pp.49-64, 2012-03-31

著者

高岡 彩子 梅野 耀弘 城戸 克己 廣村 信 片岡 裕美 飯田 浩子 田鶴谷(村山) 惠子

雑誌

日本薬学会第142年会(名古屋)

巻号頁・発行日

2022-02-01

著者

城戸 克己 廣瀬 恵美 片岡 裕美 増田 寿伸 田鶴谷(村山) 惠子

出版者

日本食品化学学会

雑誌

日本食品化学学会誌 (ISSN:13412094)

巻号頁・発行日

vol.26, no.1, pp.68-76, 2019 (Released:2019-04-26)

参考文献数

18

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Many crude drug products elicit a bitter taste, because there are a variety of bitter components in them. However, there are no good methods of masking their bitter taste. Therefore, new masking methods are widely required. As a general method to administer crude drug products to patients, they are dissolved in hot water or mixed in food or juice. However, there is a risk that patients may not want to eat the food if the crude drug products alter the taste of the food. In this study, we conducted a sensory evaluation including a questionnaire in order to examine the improvement effect on swallowing a crude drug product in food. The screening tests were carried out to reveal what kinds of foods could improve the taste and texture of the crude drug product by mixing them with 30 kinds of foods. In the screening test, a statistically significant effect was observed on masking bitter taste. Based on this screening test, the bitterness masking tests were carried out with 6 kinds of foods. As a result, a commercially available swallowing aid jelly, vanilla ice cream, chocolate ice cream, condensed milk, peanut cream, and seaweed tsukudani significantly reduced the bitterness of the crude drug product. The tastes of these foods are strong, so it is necessary for patients with sugar and salinity limitations to consider the usage of these foods. These foods are relatively inexpensive and easy to obtain. Therefore, they might be useful for patients to take medicines such as bitter crude drug products following the instructions of a physician.

著者

城戸 克己 浦 公統 福田 直通

出版者

第一薬科大学

雑誌

第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)

巻号頁・発行日

no.31, pp.41-48, 2015-03-31

著者

城戸 克己 盛満 法子 福田 直通

出版者

第一薬科大学

雑誌

第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)

巻号頁・発行日

no.32, pp.43-53, 2016-03-31