2 0 0 0 OA 認知症に対する漢方療法 : 黄連解毒湯、釣藤散
- 著者
- 城戸 克己 徳光 里弥 伊比禮 真希 福田 直通
- 出版者
- 第一薬科大学
- 雑誌
- 第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)
- 巻号頁・発行日
- no.30, pp.89-97, 2014-03-31
Cognitive deficits and behavioral and psychological symptoms of dementia(BPSD) are typical features of patients with dementia such as Alzheimer’s disease(AD), vascular dementia(VD), and other forms of senile dementia.Kampo medicine is used frequently against dementia. Orengedokuto and Chotosan are Kampo medicines that has been used clinically for the treatment of dementia.Clinical evidence has demonstrated the potential usefulness of Orengedokuto and Chotosan, in the treatment of cognitive disturbance and BPSD in dementia patients.In double-blind controlled study ,Chotosan was statistically superior to the placebo in global improvement rating, utility rating, global improvement rating of subjective symptoms, global improvement rating of psychiatric symptoms and global improvement rating of disturbance in daily living activities.Efficacy and safety of some campo medicines for dementia has reported.Kampo medicines for dementia is promising therapy which maintain QOL for patients and caregivers.In conclusion, Orengedokuto and Chotosan are useful option for the treatment of cognitive impairment in dementia.Further extensive studies need to be conducted to elucidate in more detail mechanisms.
2 0 0 0 OA 「小青竜湯の基礎と臨床研究」の紹介
1 0 0 0 OA 頭痛と漢方薬
- 著者
- 城戸 克己 浦 公統 福田 直通
- 出版者
- 第一薬科大学
- 雑誌
- 第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)
- 巻号頁・発行日
- no.31, pp.41-48, 2015-03-31
1 0 0 0 OA アトピー性皮膚炎と漢方薬 : 補中益気湯を中心に
- 著者
- 城戸 克己 盛満 法子 福田 直通
- 出版者
- 第一薬科大学
- 雑誌
- 第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)
- 巻号頁・発行日
- no.32, pp.43-53, 2016-03-31
1 0 0 0 OA 塩化ベルベリンの再結晶条件の最適化及び高速液体クロマトグラフィーによる純度測定
- 著者
- 福田 直通 米光 美知子
- 出版者
- 公益社団法人 日本分析化学会
- 雑誌
- 分析化学 (ISSN:05251931)
- 巻号頁・発行日
- vol.54, no.1, pp.79-82, 2005 (Released:2005-04-08)
- 参考文献数
- 3
- 被引用文献数
- 2 2
Berberine and palmatine are isoquinoline alkaloids contained in “oubaku”, Phellodendri Cortex, and their structures are similar. The Rf values of TLC and the retention times (HPLC) of these compounds are close. Their complete separation is difficult; a small quantity of palmatine chloride exists even in a commercial berberine chloride. Some crystals exist in the Student practice, from gel-type crystals (small needles) to big needles according to the volume of water. These phenomena suggest that a possibility exist to purify berberine chloride only by recrystallization. We recrystallized 3 times crude berberine (10 g, gained from the Student practice) from 140 ml of water per 1 g, and separated pure needles (neally 100%, 2.31 g) which were checked with HPLC.