著者

塚田 愛 池本 英志 井上 達貴 小島 衣里加 福岡 聖也 砂川 正隆

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.80, no.4, pp.296-302, 2021-08-31 (Released:2021-10-02)

参考文献数

37

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Several Japanese herbal medicines (Kampo), including Yokukansan, Yokukansankachimpihange, Shigyakusan, Kososan, Kamishoyosan, Kamikihito, Saikokaryukotsuboreito, Keishikaryukotsuboreito, Hangekobokuto, and Rikkunshito, are clinically used for patients with stress-related symptoms and diseases, according to the patient's constitution and symptoms (`Sho' in Oriental medicine). Kamikihito and Yokukansan are prescribed for the treatment of insomnia and neurosis in Japan. However, the precise mechanisms of actions of these products remain unclear. We investigated their possible antistress effects and involvement of oxytocin in the mechanisms of their actions in an animal model of stress. Oxytocin is a posterior pituitary hormone related to uterine contraction and milking. In recent years, its effects in the central nervous system-including its antistress effect-have been attracting interest. Oxytocin is reported to reduce stress levels via regulation of activities in the hypothalamic-pituitary-adrenal axis. Administration of Kamikihito or Yokukansan significantly increased the secretion of oxytocin in acute stress situations and exerted an antistress effect. Furthermore, the effects of these drugs were partially abrogated by administration of an oxytocin receptor antagonist. These results suggest that Kamikihito and Yokukansan have antistress activity and that increased oxytocin secretion may be involved in the mechanism underlying this effect. In clinical practice, the target candidates for these two drugs are different. Although both are used for irritability, anger and insomnia, Kamikihito is generally prescribed to patients who are physically weak, have weak digestive functions, or complain of mental anxiety. Yokukansan, on the other hand, is prescribed to patients with moderate physical strength, who are sensitive, and easily excited. These Kampo medicines may also be useful for stress-induced symptoms and illnesses.

著者

砂川 正隆 藤原 亜季 池本 英志 塚田 愛

出版者

日本自律神経学会

雑誌

自律神経 (ISSN:02889250)

巻号頁・発行日

vol.56, no.3, pp.150-154, 2019 (Released:2019-09-27)

参考文献数

26

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鍼治療は,不安障害,抑うつ,双極性障害,睡眠障害などの精神的要因の関連する症状にも適応されている.オレキシンは視床下部で分泌される神経ペプチドで,種々の自律機能の調節に関与しているが,ストレス反応の制御にも関与している.我々は,ラット社会的孤立ストレスモデルを用い,精神的ストレスに対する円皮鍼の効果,ならび作用機序の検討としてオレキシンの関与を調べた.7日間の孤立ストレス負荷によって攻撃性,コルチコステロンの分泌が上昇し,またオレキシンの分泌も上昇した.しかしながら,百会穴への円皮鍼治療によっていずれの上昇も抑制された.円皮鍼はオレキシンの分泌抑制を介して,ストレス反応を抑制したと考えられる.