著者

谷名 寧子 室井 政子 丁 元鎮 大谷 トミ子 吉上 裕子 中村 順 真崎 規江 坂上 吉一

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.18, no.5, pp.510-515, 1992-10-20

被引用文献数

6 1

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The chemical stability and the microbial numbers of non-sterilized and sterilized 0.1% allopurinol gargle (allopurinol gargle) were studied. Furthermore, studied the efficacy for some patients who were afflicted with oral mucositis. Allopurinol gargle (0.1%) was chemically stable under the storage in the room temperature or in the refrigerator at least for 15 days. Bacterial numbers in the non-sterilized samples increased at regular interval, while the sterilized sample wasn't detected the bacterial colonies for 15 days. On the therapeutical efficacy of allopurinol gargle for 8 patients, all 8 cases were judged effective. However, we think that more modification to the allopurinol gargle preparation and more clinical data would be needed.