1 0 0 0 除菌スプレー製品の空間除菌効果の標準化
1 0 0 0 OA 海洋中のカロテノイド産生微生物の探索並びにその生産性の向上に関する研究
- 著者
- 坂上 吉一 住谷 保治 米虫 節夫
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.130, no.11, pp.1445-1451, 2010-11-01 (Released:2010-11-01)
- 参考文献数
- 8
- 被引用文献数
- 2 3
Carotenoids are liposoluble pigments widely distributed in nature. More than 750 carotenoids are isolated from natural sources, but only a few kinds are used industrially. The production of carotenoid by microorganisms is to be expected, but few carotenoids originate from living things on land. And there is little knowledge about carotenoid-producing microorganisms in the oceans. The possibility still exists of discovering new carotenoid-producing microorganisms. Sunlight is very strong in subtropical regions. The surface of the sea and coral reefs in these regions is a severe environment for growth of microorganisms. While such conditions produce reactive oxygen species, the continuing strong irradiation can also lead to damaging and lethal photo-oxidative reactions. Many undiscovered microorganisms may possess protective mechanisms such as anti-oxidative activities for survival in this environment. This study focused on marine microorganisms inhabiting coral reefs in the Okinawa area, especially carotenoid-producing bacteria possessing anti-oxidative activities. Many carotenoid-producing microorganisms were collected from subtropical ocean areas (a total of 334 strains of pigmented microorganisms), and the chemical composition, some culture conditions and genetic characteristics of the carotenoids from these microorganisms were examined. Furthermore, similar research was performed using some creatures from the ocean surrounding Kochi Prefecture.
1 0 0 0 アロプリノール含嗽水の安定性並びに臨床使用効果
- 著者
- 谷名 寧子 室井 政子 丁 元鎮 大谷 トミ子 吉上 裕子 中村 順 真崎 規江 坂上 吉一
- 出版者
- 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.18, no.5, pp.510-515, 1992-10-20
- 被引用文献数
- 6 1
The chemical stability and the microbial numbers of non-sterilized and sterilized 0.1% allopurinol gargle (allopurinol gargle) were studied. Furthermore, studied the efficacy for some patients who were afflicted with oral mucositis. Allopurinol gargle (0.1%) was chemically stable under the storage in the room temperature or in the refrigerator at least for 15 days. Bacterial numbers in the non-sterilized samples increased at regular interval, while the sterilized sample wasn't detected the bacterial colonies for 15 days. On the therapeutical efficacy of allopurinol gargle for 8 patients, all 8 cases were judged effective. However, we think that more modification to the allopurinol gargle preparation and more clinical data would be needed.