著者

川合 暢彦 中村 彩花 大谷 淳二 本川 雅英 當麻 愉衣子 西 美香 丹根 一夫

出版者

日本矯正歯科学会

雑誌

Orthodontic waves : 日本矯正歯科学会雑誌 (ISSN:13490303)

巻号頁・発行日

vol.68, no.2, pp.75-82, 2009-06-25

参考文献数

39

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矯正歯科を受診した不正咬合患者における外傷既往の実態を把握するとともに,外傷と不正咬合の関連性を明らかにするため,2001年8月から2005年11月の期間に広島大学病院矯正歯科を受診した不正咬合患者1,000名を対象とした調査を行い,以下の結果を得た.1.外傷既往歴を有する不正咬合患者は1,000名中51名(5.1%)であった.そのうち,当科受診前に受傷した者が38名,当科にて治療中もしくは保定中に受傷した者が14名で,うち2名が重複した既往を有していた.2.受傷部位は乳歯,永久歯ともに上顎前歯が最も多かった.3.不正咬合については,患者全体では叢生が最も多かったが,外傷既往歴を有する患者では上顎前突が最も多く,約5割を占めていた.4.ほとんどの症例において,適切な外傷歯の処置により,その後の矯正歯科治療に大きな影響が及ぼなかったものの,打撲により乳歯の転位や埋入が生じ,後継永久歯への交換錯誤を引き起こした症例や外傷が顎偏位の原因と考えられる症例も認められた.外傷既往者に上顎前突の患者が多く,上顎前歯部が最も多い受傷部位であったことから,若年期に上顎前突の改善を行うことは,その後の健全な生活にとってきわめて有益と考えられる.また,外傷が不正咬合の原因となる症例も存在することから,初診時に外傷の既往について診査することの重要性が示された.

著者

有吉 眞理子 大谷 淳二 白川 昌宏

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.1, pp.3-9, 2015-01-01 (Released:2015-01-01)

参考文献数

17

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DNA methylation is one of the major epigenetic marks in the mammalian genome to define chromatin higher-order structure, and plays essential roles in various developmental processes. In the mammalian genome, DNA methylation mainly occurs at the 5th position of cytosine bases in a palindromic 5′-CG-3′dinucleotide sequence. Methyl CpG binding domain (MBD) proteins recognize symmetrically methylated CpG sites (5mCG/5mCG) through a conserved MBD, and recruit transcriptional repressors or chromatin modifiers. One of the MBD proteins, MBD4, uniquely contains a C-terminal glycosylation domain together with an N-terminal MBD, and functions as a mismatch DNA repair enzyme specific for T/G or U/G mismatch bases generated by spontaneous deamination of 5-methylcytosine. The base excision activity of MBD4 is also implicated in active DNA demethylation initiated by the conversion of 5-methylcytosine to thymine by deaminases. Unlike other MBD proteins, MBD4 recognizes not only 5mCG/5mCG but also T/G mismatched sites generated by spontaneous deamination of 5-methylcytosine (5mCG/TG). In addition, our biochemical data demonstrate that MBD also binds to intermediates in DNA demethylation pathways, such as 5-hydroxymethyl-cytosine (hmC), 5-carboxyl-cytosine and 5-hydroxy-uracil. The crystal structures of MBDMBD4 in complex with 5mCG/TG, 5mCG/5mCG or 5mCG/hmCG provide new structural insights into the versatility of base recognition by MBD4. A DNA interface of MBD4 has flexible structural features, in which an extensive hydration water network supports the versatile base specificity of MBD4. The versatile base recognition by MBDMBD4 implies multi-functional roles of MBD4 in the regulation of dynamic DNA methylation patterns.

著者

砂川 紘子 大谷 淳二 佐野 良太 椿本 昇子 藤田 正 丹根 一夫

出版者

THE JAPANESE SOCIETY FOR JAW DEFORMITIES

雑誌

日本顎変形症学会雑誌 = The Japanese journal of jaw deformities (ISSN:09167048)

巻号頁・発行日

vol.20, no.1, pp.8-14, 2010-04-15

参考文献数

32

被引用文献数

2

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Idiopathic scoliosis is a well-known orthopedic disease in childhood and the onset and progress are observed during adolescence. It is speculated that the progress of idiopathic scoliosis affects the maxillofacial growth and the function of the temporomandibular joint because the craniofacial skeletal is located on the top of the spinal column. Another reason may be that asymmetric craniofacial growth changes the head posture and/or spinal column. In this study, we examined the association of scoliosis with jaw deformity and temporomandibular joint disorders.<br>The subjects were 44 patients who underwent orthognathic surgery for treatment of a jaw deformity at Hiroshima University Hospital. We measured the Cobb angle, an indicator of scoliosis, and the curve of the spinal column in vertebrae thoracicae on the chest radiograph. Moreover, the lateral shift of points A and B, cant of the occlusal plane and ANB angle were measured on the postero-anterior (PA) plane and lateral cephalograms. Association between the curve of the spinal column and maxillofacial morphology was examined by correlation analysis. The degree of scoliosis was examined in association with the pathological status of temporomandibular joint.<br>The prevalence of subjects diagnosed with scoliosis was 22.7%. Among the scoliosis patients, 70% were female. In all subjects with a jaw deformity, a significantly positive correlation was not found between the following variables and the Cobb angle: ANB angle, lateral shift of points A and B, cant of the occlusal plane. Moreover, no significant association between the curve of spinal column in the vertebrae thoracicae and previous variables was revealed. In addition, there was no relationship between the degree of the scoliosis and progress of the temporomandibular joint disorder.<br>These findings suggested that the progress of scoliosis exerts no substantial influence on the growth of the maxillofacial skeleton and the progress of temporomandibular joint disorders.