著者

中嶋 洋子 真田 宏夫 宇津木 良夫 河田 正治

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.24, no.2, pp.67-76, 1978 (Released:2009-04-28)

参考文献数

29

被引用文献数

4 4

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Effect of nicotinic acid on the formation of catecholamine has been studied. Norepinephrine and dopamine concentrations in brain were 30 per cent higher and brain catecholamine formation was 50 per cent higher in the nicotinic acid-supplemented rats than the nicotinic acid-deficient rats. However, these catecholamine levels of the nicotinic acid-deficient rats were recovered by the administration of nicotinic acid. The concentration of brain tyrosine was unaltered after administration of nicotinic acid to the nicotinic acid-deficient rats. Therefore, the changes catecholamine formation by the nicotinic acid supplementation were not due to the difference of tyrosine concentration in the brain which is the precursor for catecholamine biosynthesis. As the difference of catecholamine concentration between the nicotinic acid deficient and the nicotinic acid supplemented group was smaller than that of catecholamine formation of these groups, the turnover of catecholamine was supposed to be decreased in nicotinic acid deficiency.

著者

中嶋 洋子 真田 宏夫 宇津木 良夫 鈴江 緑衣郎

出版者

特定非営利活動法人 日本栄養改善学会

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.37, no.3, pp.107-115, 1979-05-25 (Released:2010-10-29)

参考文献数

24

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Tyrosine hydroxylase activity in the brain homogenate increased and nicotinic acid content in the brain and liver decreased in rats fed a tryptophan-imbalanced diet. In order to clarify the function of nicotinic acid, we studied the causes of increase in tyrosine hydroxylase activity in the tryptophan-imbalanced rats.1) Tyrosine hydroxylase activity in the brain and nicotinic acid content in the liver and brain were not changed by the administration of nicotinic acid to rats fed on a 7% casein diet. However, tyrosine hydroxylase activity increased and nicotinic acid content decreased in rats fed on a 7% casein diet supplemented with methionine (0.3g/100g diet) and threonine (0.36g/100g diet), but normal activity and content were recovered by the administration of nicotinic acid or tryptophan.2) In tryptophan-deficient rats, tyrosine hydroxylase activity and nicotinic acid content were not changed by the administration of nicotinic acid.3) In protein-deficient rats, tyrosine hydroxylase activity and nicotinic acid content were not changed by the administration of nicotinic acid.4) Tyrosine hydroxylase activity was increased and nicotinic acid content was decreased by the administration of tryptophan to tryptophan or protein-deficient rats.5) A positive correlation was observed between the tryptophan content in the diet and the total nicotinic acid content in the brain. A negative correlation was noted between the total nicotinic acid content in the brain and the level of tyrosine hydroxylase activity. It was therefore, considered that the level of tyrosine hydroxylase activity in the brain was directly influenced by the nicotinic acid content in it, and that the level of nicotinic acid was maintained by tryptophan.