著者

中嶋 洋子 鈴江 緑衣郎

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.29, no.5, pp.579-587, 1983 (Released:2009-04-28)

参考文献数

27

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Ten-week old rats were fed an AIN-76 purified diet ad libitum and were given 3-acetylpyridine which is an antagonistic agent of nicotinic acid. The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebroside level and specific activity of 2', 3'-cyclic nucleotide-3'-phosphohydrolase in the brain decreased by administration of 3-acetylpyridine. Despite the decreased myelin yield, the proportion of protein and total lipid and the percentage composition of lipid in myelin did not change by administration of 3-acetylpyridine. Therefore, we have concluded that 3-acetylpyridine plays a significant role in the loss of myelin.

著者

鈴江 緑衣郎 力石 サダ

出版者

公益社団法人 日本ビタミン学会

雑誌

ビタミン (ISSN:0006386X)

巻号頁・発行日

vol.52, no.1, pp.58, 1978-01-25 (Released:2018-03-07)

著者

鈴江 緑衣郎

出版者

The Japanese Society of Nutrition and Dietetics

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.42, no.3, pp.159-166, 1984 (Released:2010-04-30)

参考文献数

32

著者

鈴江 緑衣郎

出版者

特定非営利活動法人 日本栄養改善学会

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.31, no.3, pp.135-140, 1973-05-25 (Released:2010-10-29)

参考文献数

36

著者

中嶋 洋子 真田 宏夫 宇津木 良夫 鈴江 緑衣郎

出版者

特定非営利活動法人 日本栄養改善学会

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.37, no.3, pp.107-115, 1979-05-25 (Released:2010-10-29)

参考文献数

24

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Tyrosine hydroxylase activity in the brain homogenate increased and nicotinic acid content in the brain and liver decreased in rats fed a tryptophan-imbalanced diet. In order to clarify the function of nicotinic acid, we studied the causes of increase in tyrosine hydroxylase activity in the tryptophan-imbalanced rats.1) Tyrosine hydroxylase activity in the brain and nicotinic acid content in the liver and brain were not changed by the administration of nicotinic acid to rats fed on a 7% casein diet. However, tyrosine hydroxylase activity increased and nicotinic acid content decreased in rats fed on a 7% casein diet supplemented with methionine (0.3g/100g diet) and threonine (0.36g/100g diet), but normal activity and content were recovered by the administration of nicotinic acid or tryptophan.2) In tryptophan-deficient rats, tyrosine hydroxylase activity and nicotinic acid content were not changed by the administration of nicotinic acid.3) In protein-deficient rats, tyrosine hydroxylase activity and nicotinic acid content were not changed by the administration of nicotinic acid.4) Tyrosine hydroxylase activity was increased and nicotinic acid content was decreased by the administration of tryptophan to tryptophan or protein-deficient rats.5) A positive correlation was observed between the tryptophan content in the diet and the total nicotinic acid content in the brain. A negative correlation was noted between the total nicotinic acid content in the brain and the level of tyrosine hydroxylase activity. It was therefore, considered that the level of tyrosine hydroxylase activity in the brain was directly influenced by the nicotinic acid content in it, and that the level of nicotinic acid was maintained by tryptophan.

著者

鈴江 緑衣郎

出版者

特定非営利活動法人 日本栄養改善学会

雑誌

栄養学雑誌 (ISSN:00215147)

巻号頁・発行日

vol.45, no.4, pp.181-183, 1987-08-01 (Released:2010-04-30)