著者

大浦 新 鈴木 佐知子 秦 洋二 川戸 章嗣 安部 康久

出版者

公益財団法人 日本醸造協会

雑誌

日本醸造協会誌 (ISSN:09147314)

巻号頁・発行日

vol.102, no.10, pp.781-788, 2007-10-15 (Released:2011-09-20)

参考文献数

14

被引用文献数

1 9

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Amazake is a traditional Japanese beverage made from sake cake or rice-koji produced in sakebrewing process. Recent progressive studies showed that sake cake and rice-koji had various physiological functionalities, such as anti-hypertension, anti-obesity and anti-amnesia. Such functionalities were anticipated in amazake, so we investigated the effects of amazake in mice. Administration of amazake to mice fed a high fat diet for 2 weeks suppressed increases in body weight, serum concentrations of triglycerides, and intraperitoneal adipose depots accumulations. When amazake was orally administrated to salt-induced hypertensive mice, blood pressure showed a significant decrease after 50days of breeding. When impairment of learning and memory in mice was induced by a subcutaneous injection of scopolamine, prior oral administration of amazake prevented a decrease in performance for memory and learning even in a single dose. These results demonstrated that amazake has three types of health-promoting benefits--anti-obesity, anti-hypertension, and anti-amnesia--resulting from attributions of sake cake, rice-koji, and other elements of sake-brewing. These functionalities indicated that amazake should be newly recognized as a natural and healthy drink for the prevention of lifestyle-related diseases.