- 著者
- 塩見 道夫 佐々木 邦明 室伏 貢 粟飯原 景昭
- 出版者
- National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
- 雑誌
- Japanese Journal of Medical Science and Biology (ISSN:00215112)
- 巻号頁・発行日
- vol.35, no.2, pp.75-80, 1982 (Released:2010-03-19)
- 参考文献数
- 6
- 被引用文献数
- 63 90
The antitumor activity of a water-soluble polysaccharide (KGF-C), isolated from the Kefir grain, was studied in the mice subcutaneously inoculated with Ehrich carcinoma (EC) or Sarcoma 180 (S-180) . The growth of EC and S-180 solid tumor was inhibited by 40-59% and 21-81%, respectively, by oral administration of KGF-C as compared with the unadministered mice. The tumor growth was similarly inhibited by intraperitoneal administration. The mechanism of the antitumor activity of KGF-C was considered to be host-mediated because of the lack of direct in vitro effect on tumor cells.