著者

宮下 脩平 高橋 英樹

出版者

日本ウイルス学会

雑誌

ウイルス (ISSN:00426857)

巻号頁・発行日

vol.65, no.2, pp.199-208, 2015-12-25 (Released:2016-10-19)

参考文献数

31

被引用文献数

1 3

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植物は獲得免疫をもたない.その代替として,多数のNB-LRR型免疫レセプターによりそれぞれの病原体を特異的に認識し,抵抗性反応を誘導する機構を持っている.NB-LRR型免疫レセプターをコードする遺伝子は,これまでに植物で報告された優性抵抗性遺伝子(R遺伝子)の大半を占める.本稿では植物ウイルスの認識に関わるNB-LRR型R遺伝子について,抵抗性メカニズム・進化・農業上の利用の観点から概説するとともに,近年明らかになったmiRNAやイントロンによるNB-LRR型R遺伝子の発現調節機構について紹介する.また,NB-LRR型R遺伝子が引き起こす興味深い現象の一つにウイルス感染開始点周辺のプログラム細胞死があるが,それが植物の生存戦略にもたらす意義については明らかでない.これについて,筆者らの実験結果や生態学的見地からの推論をもとに議論する.

著者

増山 英則 嶋田 寛子 木下 次子 田尻 貞雄 今村 昌耕 高瀬 昭 江原 直 瀬倉 敬 宮下 脩 許 栄宏 中島 丈夫 山口 智道 徳地 清六

出版者

JAPANESE SOCIETY FOR TUBERCULOSIS

雑誌

結核 (ISSN:00229776)

巻号頁・発行日

vol.68, no.4, pp.301-312, 1993

被引用文献数

2

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We studied 130 cases of pulmonary tuberculosis in foreigners residing in Japan to obtain the results as follows;<BR>1. Of the cases of pulmonary tuberculosis in foreigners who are registered and receiving treatment in Japan, 20.3% were treated at three dispensaries of the Japan Anti-tuberculosis Association in Tokyo.<BR>2. The nationality of the cases treated was China in more than half of them, followed by the Republic of Korea.<BR>3. The number of days taken from entry into Japan to the start of treatment was about 11.4 months; 0.9% of the total number of cases examined by chest radiophotography required medical treatment.<BR>4. Their living conditions in Japan according to questionnairing are: 56.2% have jobs in Japan; working hour, 4.99±1.19 hours a day; 64.4% take night work; 57.6% work in food/drink service industry; living space is 12.5 m<SUP>2</SUP>; 52.4% share the same house with other persons, living together with 1.6 persons.<BR>5. As for the type of illness at the start of treatment, GAKKAI classification type III accounted for 90% and spread 1 83.8%. GAKKAI classification type II accounted for 10%, consisting of many relatively mild cases.<BR>6. The defaulter rate was high at 40.8%. The reason for defaulting was broken down to discontinuation on his own 68%, repatriation 15 % and side-effects 19%. The time to default was average 3.2±3.1 months after the start of treatment. They defaulted 1.2±0.4 times on the average.<BR>7. To reduce the defaulter rate to the minimum in treating the foreigners residing in Japan, the following may be needed.<BR>a. To give guidance on the regimen including the need of treatment and iisk associated with discontinuation of treatment at the first visit.<BR>b. Measures to reduce the amount to be born by the individual in the medical expenses.<BR>c. Preparation of a pamphlet for therapeutic guidance in foreign languages.