1 0 0 0 OA 急性アルコール投与におけるハムスターの凝固・線溶
- 著者
- 伊藤 要子 水谷 洋子 山田 学 宮田 伸樹 山田 高路 小栗 隆
- 出版者
- The Japanese Society on Thrombosis and Hemostasis
- 雑誌
- 日本血栓止血学会誌 (ISSN:09157441)
- 巻号頁・発行日
- vol.1, no.2, pp.134-140, 1990-04-01 (Released:2010-08-05)
- 参考文献数
- 23
Activities of clotting and fibrinolytic factors in golden hamsters under acute alcohol consumption were measured with fluorogenic peptide substrate. The obtained data were as follows;1) Concentration of blood alcohol reached to the maximum values on 1hr after administration of alcohol.2) Prothrombin and factor X activities began to decrease on 1hr after administration. But their activated form, thrombin like and factor Xa like activities significantly increased on 1hr, then returned to initial value on 4hrs after administration.3) Although plasminogen activity began to decrease on 1hr, activated form of it, plasmin like, and t-PA like activities increased on 1hr and returned to the initial values or decreased on 4hrs. Both prekallikrein and kallikrein like activities significantly increased from 1hr.Under acute alcohol consumption, activities of clotting and fibrinolytic factors (prothrombin, factor X, plasminogen) in golden hamster were changed into their activated form (thrombin, factor Xa, plasmin) at the corresponding time that concentration of blood alcohol reached to the maximum values.