著者

高野 浩一 森下 宗彦 山本 正彦 山県 香 高田 勝利

出版者

The Japanese Respiratory Society

雑誌

日本胸部疾患学会雑誌 (ISSN:03011542)

巻号頁・発行日

vol.15, no.11, pp.769-774, 1977-11-25 (Released:2010-02-23)

参考文献数

12

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BCG-CWS was administered in 30 patients with primary lung cancer, and in most cases this was in conjunction with other therapeutic procedures such as irradiation, chemotherapy and/or surgery.Oil-attached BCG-CWS was prepared by homogenizing 4mg of BCG-CWS, two drops of mineral oil and 2ml of 0.2% Tween 80 saline.Two hundred μg of BCG-CWS was injected intradermally every week. In patients with carcinomatous pleuritis, 400μg of BCG-CWS was injected into the pleural cavity every week.Prolonged survival periods in advanced lung cancer cases treated with BCG-CWS was observed in comparison with historical controls. Most of the patients showed increased PPD skin reaction and increased in vitro PHA response after BCG-CWS administration.As adverse reactions, minimal skin ulceration was observed in 37% of the patients, and fever in 57% after repeated intradermal injection of BCG-CWS, none of which necessitated the interruption of immunotherapy. No serious side effects, however, have been observed during the BCG-CWS treatment.