- 著者
- 竹内 洋文 三輪 嘉尚 森田 修之 岡田 壽太郎 タケウチ ヒロフミ ミワ ヨシヒサ モリタ シュウシ オカダ ジュタロウ HIROFUMI TAKEUCHI YOSHIHISA MIWA SHUSHI MORITA JUTARO OKADA
- 雑誌
- 岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy
- 巻号頁・発行日
- no.34, 1985-08-01
1 0 0 0 OA 臨床試験における欠測値の取り扱いに関する考察
- 著者
- 岡田 壽太郎 森田 修之
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.100, no.5, pp.524-529, 1980-05-25 (Released:2008-05-30)
- 参考文献数
- 1
To deal with missing data in clinical tests, three methods (A, B, and E) were considered. Drug efficacy was estimated by (A) using only actual data, (B) using a previous value for a missing datum, and (E) using the value estimated by the equation (1) for a missing datum. [numerical formula] where S is the symptomatic severity (S0 is at the beginning), b is the recovery rate constant, θ is the number of days after the initiation of medical treatment, and subscript i means the i-th judgment. Based on theoretical calculations and analyses of nine sets of real data in ophthalmology, orthopedics and dermatology, (i) drug efficacy estimated by B was always smaller than by E, (ii) the difference in estimated drug efficacy between A and E was very small.