著者
竹内 淑子 中坪 拓也 福居 篤子 藤井 隆太 田原 耕平 竹内 洋文
出版者
公益社団法人 日本薬剤学会
雑誌
薬剤学 (ISSN:03727629)
巻号頁・発行日
vol.77, no.3, pp.164-176, 2017-04-01 (Released:2017-05-01)
参考文献数
19

Flowability is one of the most important parameters of pharmaceutical powders during the handling and preparation of solid dosage forms. It is especially important to characterize the very poor flowability that some herbal powders show. In this study, the flowability of a traditional herbal powder formulated as an antitussive and expectorant was examined. This formulated herbal powder and two excipient powders, precipitated calcium carbonate and anhydrous dibasic calcium phosphate, were evaluated using two instruments. A shearing test, a wall friction test and a dynamic flowability test were performed with Powder Rheometer FT4 (Freeman Technology, Tewkesbury, UK). Internal friction and wall friction were measured. BFE (basic flow energy), SI (stability index) and FRI (flow rate index) were also measured. Angle of repose, bulk density, tapped density, angle of spatula and cohesiveness were measured with a Powder Tester (Hosokawa Micron, Osaka, Japan). The results were used to calculate Carr's Index values and compressibility, which in turn revealed that this herbal powder had poor flowability.The other aim of this study was to develop a new method of evaluating the flowability of powder through a medicine spoon. Two evaluation methods, the spoon-tap test and the consecutive medicine spoon test, were developed to design a new medicine spoon for the herbal powder. The results of these tests indicated that a polyethylene medicine spoon with holes at the bottom could reduce the adhesiveness to a medicine spoon of the formulated herbal powder.
著者
竹内 洋文
出版者
公益社団法人日本薬学会
雑誌
ファルマシア (ISSN:00148601)
巻号頁・発行日
vol.26, no.4, pp.362-363, 1990-04-01
著者
山本 ひとみ 戸塚 裕一 内田 実 竹内 洋文
出版者
The Society of Powder Technology, Japan
雑誌
粉体工学会誌 (ISSN:03866157)
巻号頁・発行日
vol.47, no.6, pp.388-393, 2010-06-10 (Released:2010-06-15)
参考文献数
7
被引用文献数
1 2

The lubricant property of sucrose esters of fatty acids (SEs) having different particle size and Hydrophile-Lipophile Balance (HLB) was evaluated with a model formulation in tableting. The binding tendency of the model formulation composed of isomalt powder was depressed by adding SEs in the formulation. Tablets containing SE showed faster disintegration time compared to those containing magnesium stearate or calcium stearate, while the tablets containing SEs indicated a high tensile strength. Milled SE (S-370F) exhibited better tablet properties than original SE (S-370). The SEs having different HLB showed different effects on the resultant tablet properties such as the magnitude of tensile strength, disintegration time, and spreading properties. The relatively hydrophilic SE was found to much improve the resultant disintegrating properties of tablet compared to magnesium stearate, calcium stearate and hydrophobic SEs. Consequently, SEs are able to use as lubricants on tablet formulation by appropriately controlling its particle size, content, and HLB.
著者
小野寺 理沙子 田原 耕平 竹内 洋文
出版者
日本DDS学会
雑誌
Drug Delivery System (ISSN:09135006)
巻号頁・発行日
vol.30, no.2, pp.121-128, 2015-03-25 (Released:2015-06-25)
参考文献数
17

薬物を効率よく送達するために、リポソーム、リピッドエマルション、ポリマーナノパーティクルなどのコロイド薬物キャリアーの活用が有効である。本論文では、リポソームを用いた最近のわれわれのこの分野での研究成果を経口、経肺、点眼投与の各投与ルートに関して説明する。特に、ポリマーによる粒子表面修飾を含むリポソームの粒子設計が、そのキーポイントの1つであることを述べたい。