著者

行岡 正雄 小松原 良雄 前田 晃 島岡 康則 志水 正敏 行岡 千佳子 三木 健司

出版者

一般社団法人 日本臨床リウマチ学会

雑誌

臨床リウマチ (ISSN:09148760)

巻号頁・発行日

vol.19, no.1, pp.17-23, 2007-03-30 (Released:2016-12-30)

参考文献数

17

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Purpose and Methods We investigated the relationship of the presence or absence of sleep disorder (awakeness that patients remembered)with blood sedimentation, a depression test (Zung’s self-rating depression scale, SDS), C reactive protein (CRP), and MHAQ in 207 patients with rheumatoid arthritis (RA) (32 males, 175 females), with a mean age of 58.3 years. We employed the values of blood sedimentation and CRP obtained within 1 month1from the date of this survey (mean: 11 days). Results In patients with night awakeness, the blood sedimentation value was higher than that in those without night awakeness (57.1±35.4 vs. 47.5±30.2). The values of CRP (mg/dl) (2.71±3.05 vs. 1.69±2.02), SDS (39.5±8.3vs.34.4±8.4), MHAQ (6.8±6.8 vs. 3.6±4.5), and VAS (4.22±2.55 vs. 3.38±2.32) were significantly higher (p<0.05). In addition, the frequency of night awakeness was classified: once, twice, and 3 times or more. In patients reporting a frequency of 1, the SDS score was significantly higher than that in patients without night awakeness. In those reporting a frequency of 2, the SDS and MHAQ scores were significantly higher, and in those reporting a frequency of 3 or more, the SDS, MHAQ, VAS, and face scale scores were significantly higher. In patients with depression, the MHAQ, VAS, and face scale scores were significantly higher than the values in those without depression. However, there were no significant differences in blood sedimentation or CRP. Among the patients with night awakeness, in those who reported that they had awakened due to night pain, the blood sedimentation, CRP, MHAQ, VAS, and face scale values were higher than the values in those without night pain. In the group with night awakeness, excluding patients with night pain, the CRP level was higher than that in the group without night awakeness, although there was no significant difference. The SDS and MHAQ scores were significantly higher. Discussion The results of this study suggest that sleep disorder is related to RA-related pain, depression, and RA activity. Few studies have reported the relationship between RA and sleep disorder. In the future, this issue should be further investigated.

著者

行岡 正雄 七川 歓次 行岡 千佳子 小松原 良雄 島岡 康則 正富 隆

出版者

一般社団法人 日本臨床リウマチ学会

雑誌

臨床リウマチ (ISSN:09148760)

巻号頁・発行日

vol.22, no.1, pp.32-36, 2010-03-30 (Released:2016-02-26)

参考文献数

13

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目的:関節リウマチ(RA)の尿中カテコールアミンを測定し,自律神経と気圧の変動との関連性を調査した. 対象・方法:入院RA患者9例(男2例,女7例調査時平均年齢67.67±9.87)を対象とし低気圧(990~1000hPa)中間(1001~1010hPa)高気圧(1011~1020hPa)時の尿中アドレナリン(AD),ノルアドレナリン(ND),ドーパミン(DP),バニリルマンデル酸(VMA)を調査した.尿中AD,NAD,DP,VMAの測定方法はHCLP(2―シアノアセトアミド誘導体化)法で行い,午前1時より翌日午前1時までの間に畜尿した尿を24時間尿としてSRL®にて計測した.気圧は気象庁がホームページで公表している調査当日の大阪市の気圧を用いた. 結果:尿中AD,NAD,VMAのいずれもが低気圧に比較して高気圧において尿中濃度が上昇していた.そのうちADで低気圧6.55±5.66μg/l と高気圧10.67±5.88μg/lとの間で統計学的有意差(p=0.0469)を認めた.またNADでは低気圧133.9±83.09μg/lと高気圧198.38±93.67μg/l(p=0.0265)及び中間気圧151.57±80.88μg/lと高気圧198.38±93.67μg/l との間で有意差(p=0.039)を認めた. 結論:RAでは気圧の変動と伴に自律神経が変動している.すなわち,RAでは低気圧では副交感神経優位,高気圧では交感神経優位の状態となっていることが示唆された.