著者
廣岡 孝志
出版者
北陸大学
雑誌
若手研究(B)
巻号頁・発行日
2007

メチル水銀中毒(水俣病)の脳傷害の局在性は,脳浮腫形成とそれによる二次的な循環障害に起因するとされる。しかしながら,メチル水銀による脳浮腫形成の分子機構は不明であった。申請者は,メチル水銀が,脳微小血管を構成する内皮および周皮細胞に対して特徴的な毒性を発現することを明らかにした。この結果は,メチル水銀が脳微小血管構成細胞の機能障害を介して脳浮腫を発生させる可能性を示すものである。
著者
名越 充 橋詰 博行 小西池 泰三 廣岡 孝彦 内田 圭治
出版者
日本肩関節学会
雑誌
肩関節 (ISSN:09104461)
巻号頁・発行日
vol.32, no.3, pp.665-667, 2008 (Released:2008-11-21)
参考文献数
4

Calcified tendinitis is a common shoulder disease accompanied with severe pain. We experienced many cases of calcified tendinitis over some short periods in a year. We examined the correlation between the occurrence of calcified tendinitis and seasons. 212 patients (males 72, females 140) with acute calcified tendinitis visited to 12 hospitals during two years (January. 2005-December. 2006) in the Chugoku and Shikoku area were investigated. The average age was 57.1 years old. The day of the 1st medical examination and the numbers of cases were examined. The correlation between the occurrence and 4 seasons (March-May, June-August, September-November, December-February) and the correlation in the occurrences between each areas were statistically analyzed. The correlation between the occurrence and seasons was not seen (Wilcoxon signed-rank test). In winter, the mean value of the number of cases of calcified tendonitis tended to be fewest. There was a strong correlation in occurrence between the Sanyo West and Shikoku Setouchi areas (Spearman correlation coefficient ; 0.53997, P=0.0065). More cases and analysis in various points of view are needed for evidence of the correlation between the occurrence and season.