著者

廣田 洋子

雑誌

日本公衆衛生学会総会抄録集 (ISSN:13478060)

巻号頁・発行日

vol.55, no.2, 1996-10-15

著者

廣田 洋子 武藤 正彦 廣田 徹 倉田 佳子 田尻 雅夫 麻上 千鳥

出版者

日本皮膚科学会西部支部

雑誌

西日本皮膚科 (ISSN:03869784)

巻号頁・発行日

vol.58, no.1, pp.6-9, 1996-02-01 (Released:2011-07-12)

参考文献数

7

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34歳の女性。平成4年7月頃より健康のためプロポリス(ブラジル産)を飲用していた。飲用約10ヵ月後, 運動会に参加した後, 露出部に紅斑出現。紅斑にプロポリスと馬油混合液を塗布したが皮疹に変化はみられなかった。塗布2週間後には顔面, 両前腕, 両手背, 両手掌, 両下肢に初診時にみられたと同様の瀰漫性浮腫性紅斑, 紅色丘疹, 鱗屑が認められるようになった。パッチテストを施行したところプロポリスasis, 10%pet., 1%pet. にて強陽性。馬油陰性。プロポリスによる内服テストならびに内服フォトテストにて, 共に陰性。パッチテスト, 内服テストのいずれでもflare upは認められなかった。健康人17名に施行した1%プロポリスのパッチテストでは全員陰性であった。以上よりプロポリスによるアレルギー性接触皮膚炎と診断した。

著者

廣田 洋

出版者

公益社団法人 日本表面科学会

雑誌

表面科学 (ISSN:03885321)

巻号頁・発行日

vol.24, no.11, pp.689-693, 2003-11-10 (Released:2008-12-02)

参考文献数

8

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In the post-genome sequencing era, “Structural Genomics” has become one of the most important research fields in life science. Here I introduce the outline of the study of structural genomics in RIKEN Genomic Sciences Center and also the connection between surface science and structural genomics. Structural genomics is an emerging research field, which examines the enormous amounts of information stored in the genomes of living organisms. We are trying to determine a variety of three-dimensional structures of protein mainly by NMR and also to analyze the structure-function relationship of the proteins systematically and comprehensively. In the process of protein function analysis, molecular interaction analysis is very important and we use various methods including in silico screening, mass spectrometry, surface plasmon resonance, NMR, and so on. All of these analytical methods are based on protein-ligand interaction on molecular surfaces.

著者

廣田 洋 棚橋 善昭 高橋 武美

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.19, pp.54-61, 1975-10-01

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Structure elucidation of LB, one of the volatile components of "San-shion" (Ligularia species), was accomplished in the following way. LB, C_<15>H_<26>O, was assumed to be a saturated guaiane-type sesquiterpene ether from its spectra and the dehydrogenation reaction. INDOR experiments on LB and 1-epiguaioxide(13) showed that LB is one of the eight stereoisomers of guaioxide(10). As six compounds of them are already known, the structure of LB must be represented by either 14 or 16. The reaction of LB with NBS in CCl_4 gave 4-bromo-LB(22) in 8〜18% yield. The compound(22) was dehydrobrominated into 23, which reacted with diborane to give 27. The oxidation of 27 with Jones' reagent gave the ketone(29), which then isomerized to 26. The structure of 22, 23, 26, 27, and 29 were confirmed by their spectral data, obtained by double resonance and lanthanide-induced shift techniques in PMR. The absolute structure of 29 was determined by the ORD and CD experiments. The hydrogenation of 23 gave 4-epi-LB. The compound(14) obtained by tosylation of 27 followed by reduction with LiAlH_4, was identical with 4-epi-LB. Therefore, the structure of LB was determined to be 16, including the absolute configuration.