著者

戸出 英輝 采見 憲男 川口 安郎 多比良 和基

出版者

公益社団法人 日本化学療法学会

雑誌

CHEMOTHERAPY (ISSN:00093165)

巻号頁・発行日

vol.25, no.2, pp.385-391, 1977-02-25 (Released:2011-03-08)

参考文献数

11

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FT-207 was activated to 5-FU by microsomal drug-metabolizing enzyme in the liver, and 5-FU was converted to F-β-alanine etc. in the microsomal supernatants or to FuR etc. in the nucleus.After administration of FT-207, 5-FU activated in the liver was released into the blood and then transferred to the tumor tissues.On the other hand, in experiment of the rat treated with CCl4 in vivo and of the activation of FT-207 by several tissues in vivo, it was observed that FT-207 was activated in the lung, the kidney and spontaneously besides the liver.After administration of 3H-FT-207, the radioactivities were incorporated as FUMP into the RNA fraction of tumor cells.Based on these results, we postulated that FT-207 was activated to 5-FU mainly in the liver, partially in the lung, the kidney enzymatically and in whole bodies spontaneously, was transferred to the tumor tissues and remarkably inhibited the RNA and DNA synthesis.