著者

政本 幸三

出版者

THE SOCIETY OF COSMETIC CHEMISTS OF JAPAN

雑誌

日本化粧品技術者連合会会誌 (ISSN:18846572)

巻号頁・発行日

vol.8, no.2, pp.32-39, 1974-01-15 (Released:2010-08-06)

参考文献数

10

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1. Seventeen strains of gram-negative bacteria were isolated from commercial shampoos, hair rinses, skin creams, skin lotions, hair conditioners and tooth-pastes. They were resistant against popular commercial preservatives such as carbanilide, salicylanilide and bis-phenol. Some of the isolated bacteria had the ability to oxidize raw materials commonly formulated in a shampoo or lotion, while they had the ability to utilize succharide and liquefy gelatin.The type of bacteria appeared in the product seemed to be determined by the product components, its formulation and manufacturing process.2. Bactericidal activity of several preservatives against the isolated bacteria was determined with the practical aging test in the model shampoo and lotion. In the lotion, sorbic acid was effective.The combination of p-hyproxymethyl benzoate and sorbic acid, or of p-hydroxymethyl benzoate, p-hydroxybutyl benzoate and benzoic acid was effective in the shampoo. β-bromocinnamic aldehyde and cinnamic aldehyde were also effective in the shampoo.It is suggested that the antimicrobial activity of preservatives used in cosmetic products is influenced by various factors such as pH, type of emulsifer and micellar solubilization.

著者

安藤 秀哉 橋本 晃 政本 幸三 市橋 正光 三嶋 豊

出版者

The Society of Cosmetic Chemists of Japan

雑誌

日本化粧品技術者会誌 (ISSN:03875253)

巻号頁・発行日

vol.27, no.3, pp.415-423, 1993-12-16 (Released:2010-08-06)

参考文献数

23

被引用文献数

2 3

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Linoleic acid has an inhibitory effect on melanogenesis in B16 mouse melanoma cells. Linoleic acid did not affect the expression level of tyrosinase mRNA and the pattern of tyrosinase glycosylation. The production of premelanosomes and the transfer of tyrosinase into them were also not affected by linoleic acid. The decrease of tyrosinase activity in golgi apparatus and the inhibition of melanin polymer formation within premelanosomes were found in linoleic acid-treated B16 cells.Using cultured normal human melanocytes, it was shown that linoleic acid inhibited melanogenesis as well as using B16 cells.We also report here the evidence that linoleic acid can diminish UVB-induced pigmentation. Linoleic acid was topically applied daily for one month after UVB-induced pigmentation was fully developed on the back of brownish guinea pigs, and resulted to marked depigmentation.