著者

陳 豊史 本山 秀樹 土屋 恭子 高萩 亮宏 齊藤 正男 田中 里奈 宮本 英 大畑 恵資 高橋 守 近藤 健 青山 晃博 伊達 洋至

出版者

一般社団法人 日本臓器保存生物医学会

雑誌

Organ Biology (ISSN:13405152)

巻号頁・発行日

vol.23, no.2, pp.164-167, 2016 (Released:2016-08-31)

参考文献数

15

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To overcome the severe donor shortage in lung transplantation, it is crucial to use the marginal donor lungs and lungs from cardiac-death donors, which are supposed to be actually or potentially damaged. To utilize these damaged donor lungs safely, it is important to evaluate such donor lungs objectively before lung transplantation. Recently, ex vivo lung perfusion (EVLP) was developed and has been introduced internationally. Several clinical trials are also ongoing in Europe and North America. In this situation, we also established EVLP in small and large animals. Then, we have investigated the quality of donor lungs using EVLP and tried to treat the donor lungs during EVLP before lung transplantation. We also established several injured lung models and performed various experiments using EVLP, proving that damaged donor lungs could be treated with several drugs using EVLP. Furthermore, we investigated the detection of the regional lung damage using thermography. Herein, we demonstrated our findings and discussed the future of EVLP.