- 著者
- 松尾 貴史
- 出版者
- 公益社団法人 有機合成化学協会
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.79, no.4, pp.311-321, 2021-04-01 (Released:2021-04-07)
- 参考文献数
- 49
Hoveyda-Grubbs-type complexes with a ruthenium center coordinated by an N-heterocyclic carbene (NHC) and a 2-alkoxybenzylidene ligands have gained increased applicative importance as catalysts for olefin metathesis because the complexes have suitable reactivities and stabilities in a wide range of reaction media. Furthermore, this type of catalysts has also been applied for biochemical research projects including the construction of artificial biocatalysts and the regulation of in-cell bioreactions because the ruthenium-olefin interaction, a driving force of olefin metathesis mediated by Hoveyda-Grubbs-type complexes, provides the specificity among functional groups in biomolecules. In this context, we have investigated the structural modification of Hoveyda-Grubbs-type complexes aiming at the application of the complexes to biomolecules. In parallel, we have also studied the mechanism of olefin metathesis in aqueous media. In this article, we firstly describe the construction of an artificial metalloenzyme with olefin metathesis activity using α-chymotrypsin. The artificial metalloenzyme displayed the substrate specificity with the protein surface charge state. Next, we demonstrate the importance of chloride anion in solutions to attain efficient olefin metathesis reactions in aqueous media and the reactivity control of Hoveyda-Grubbs-type complexes through second-coordination sphere effect. Finally, we introduce the ruthenium complex transfer reaction between Hoveyda-Grubbs-type complexes and biomolecules (peptides and proteins) through the ruthenium-olefin specific interaction. The reaction potentially serves a new type of chemical modification strategy toward biomolecules.
- 著者
- 松尾 貴史
- 出版者
- 日経BP社
- 雑誌
- 日経systems (ISSN:18811620)
- 巻号頁・発行日
- no.196, pp.90-95, 2009-08
松尾 貴史サイオステクノロジー ITインフラソリューション部 プロフェッショナルサービスグループ エンジニア,キャンディット 代表取締役 米Googleの「Google App Engine」(以下,GAE)は,Webアプリケーションの開発・実行環境を提供するサービスです。前回はGAEの概要編として,サービスの全体像や開発の流れ,データベース・サービスの概要などを説明しました。
1 0 0 0 なぜ宇宙人は地球に来ない? : 笑う超常現象入門
1 0 0 0 OA 窒素硅軸受球の転がり疲労特性
- 著者
- 市川 昌弘 高松 徹 松尾 貴史 岡部 永年 阿部 豊
- 出版者
- 社団法人日本材料学会
- 雑誌
- 材料 (ISSN:05145163)
- 巻号頁・発行日
- vol.42, no.483, pp.1406-1411, 1993-12-15
- 被引用文献数
- 2 2
Rolling fatigue tests were carried out on hot isostatically pressed silicon nitride bearing balls.At three load levels of the maximum Hertzian contct pressure p_<max>=5900,6740 and 7110 MP_a,13 balls each were tested,and the life distribution was studied.It was found that the rolling fatigue life followed approximately a 2-parameter Weibull distribution with the shape parameter of a 〓 1 at each load level.The relationship p^k_<max>L_<50>=const(x〓10) was found between p_<max> and the median life L_<50>.Microscopic observationof flaking was also performed,and two types of flaking were found.One is flaking with the depth of the order of 100μm,and the other is a shallower one.The depth of the former type was found to coincide aproximately with the depth at which the maximum shear stress ocurred.At lower load levels,the former type was dominant.Frequency of appearance of the latter type increased with an increase in load level.Comparing the shape parameter of a〓1 and the exponent of x〓10 mentioned above with those for the cylic bending fatigue of plain specimens of silicon nitride,it was suggested that the mechanism of rolling fatigue of silicon nitride was different from that of cyclic bending fatigue of the same material.
- 著者
- 松尾 貴史
- 出版者
- 日経BP社
- 雑誌
- 日経systems (ISSN:18811620)
- 巻号頁・発行日
- no.195, pp.90-95, 2009-07
松尾 貴史サイオステクノロジー ITインフラソリューション部 プロフェッショナルサービスグループ エンジニアキャンディット 代表取締役 米Googleが提供する「Google App Engine(以下,GAE)」は,Webアプリケーションの開発・実行環境を提供するサービスです。基本的にはGoogle検索サービスと同じシステム基盤なので,スケーラビリティに優れた実行環境であるといえるでし…