著者

松本 崇弘

出版者

公益社団法人 石油学会

雑誌

Journal of the Japan Petroleum Institute (ISSN:13468804)

巻号頁・発行日

vol.65, no.4, pp.134-139, 2022-07-01 (Released:2022-07-01)

参考文献数

42

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錯体化学は,長い歴史の中で,経験則 · 物理化学 · 量子化学に基づく金属錯体のデザイン合理性「錯体化学的スマートデザイン」を確立してきた。これまでに報告されてきた数多くの金属錯体は,論理的に説明可能な設計原理に基づいて,その機能や性質の発現機構を理解することができる。本論文では,ターゲット反応を誘起するデザイン合理性により達成したいくつかの代表的な研究,特に酸素 · 水素 · メタンの変換反応について解説する。酸素を酸化剤とする芳香族環の水酸化 · スチレンのエポキシ化 · C–H結合の酸化は,二核銅酸素錯体を合理的にデザインすることで誘起させることができる。水素の酸化と酸素の還元は,二核ニッケル · 鉄錯体のバタフライ構造によって促され,水素燃料電池の電極触媒への展開も可能とした。酸素を用いるメタンの変換は,有機ルテニウム錯体に光エネルギーをインプットすることで発現する高い酸化力によって達成している。

著者

大塚 誠 松本 崇弘 金庭 延慶

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.4, pp.1784-1793, 1986-04-25 (Released:2008-03-31)

参考文献数

9

被引用文献数

70 95

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The effect of grinding in an agate centrifugal ball mill at 200 rpm on the physicochemical properties of indomethacin (IMC) polymorphs was studied by means of X-ray diffraction analysis, infrared spectroscopy and differential scanning calorimetry. The α and γ forms (metastable and stable forms) of IMC were ground at 4°C ant at 30±0.5°C, and the degree of crystallinity (Xc) of the ground products was measured by the X-ray diffractional internal standard method.The Xc of the γ form ground at 4°C decreased with increasing grinding time, and was 0% after 4 h, that is, the γ form had been converted to a noncrystalline solid. After grinding for 1 h at 30°C, about 45% of γ form of IMC was converted to noncrystalline solid, while the product ground for 10 h was transformed to the α form.The Xc of the α form ground for 2 h at 4°C was 0%, that is, the αform had been converted to a noncrystalline solid within 2 h at 4°C. The Xc of the α form ground at 30°C decreased with increasing grinding time and the value after 10 h was about 60%.The solubility in distilled water at 35°C of the γ form ground for 10 h at 4°C was about 60% larger than that of the intact γ form. The solubilities of the γ form gournd for 10 h at 30°C, the α form gound for 10 h at 4°C and the α form gound for 10 h at 30°C were all the same, 0.94 mg/100 ml, which is equal to that of the α form at 35°C.

著者

松本 崇弘

出版者

昭和大学

巻号頁・発行日

1990

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博士論文

著者

金庭 延慶 市川 順一 松本 崇弘

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.36, no.3, pp.1063-1073, 1988-03-25 (Released:2008-03-31)

参考文献数

12

被引用文献数

5 8

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Polymorphism of phenylbutazone was investigated in detail. Pure α form of phenylbutazone could not be obtained by conventional methods, but it was found that the β form was transformed to the stable α form in ethanol solution at 4°C. At 15 and 25°C, the β form was transformed to a mixture of the α and δ forms, while at 35°C, tha α form in the mixture was converted to the δ form. These results showed that the preparation of a pure polymorphic form by means of recrystallization in solution is not necessarily straightforward. The dissolution bethavior of each form in buffer solution was examined next. The transition temperatures of the pairs of α and δ forms and of α and β forms were 29.0 and 61.6°C, respectively, in buffer solution as determined by means of the non linear van't Hoff model proposed by Grant et al. The heats of fusion of the α, β and δ forms were 8.74, 6.48 and 6.85 kcal/mol, and their melting points were 91.2, 93.3 and 101.4°C, respectively. These results suggested that the pair of β and δ forms is in a monotropic relation and the pairs of a α and β forms and of α and β forms are in enantiotropic relationships.