著者

金田 達也 大谷 誠司 高根 浩 椎木 芳和 林原 正和 大坪 健司

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.3, pp.187-193, 2011 (Released:2012-04-25)

参考文献数

9

被引用文献数

2 2

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To ensure the proper use of drugs,pharmacists must pay attention to drug incompatibility information.However,drug incompatibilityinformation relating to tablets or capsules in one-dose packages (DII) is not well understood.Therefore,weactively collected DII and shared it with Tottori West District pharmacists and investigated how they currently dispensedone-dose packages as well as their degree of understanding of DII.For sharing,we selected 3 combinations of one-dosepackage including the olmesartan medoxomil(OM)-metformin hydrochloride (MET) combination for which incompatibilityhad actually been reported in our area.Before sharing DII,hardly any of the pharmacists knew about such information inthe package inserts,suggesting that it was not widely available to them.Our sharing of DII enhanced understanding of itfor all combinations.Also,the dispensing of one-dose packages was improved in many hospitals and community pharmacies.This suggestedthat the active collection of DII and its sharing by pharmacists helped ensure proper drug use.However,we should shareDII continuously to achieve a thorough understanding of it and additional methods may be required (for example,makingpresentations at meetings) for this purpose.We should also actively collect DII because the DII in package inserts is insufficientto ensure proper drug use.

著者

森田 俊博 海浪 裕子 林原 正和 大坪 健司

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.24, no.3, pp.237-242, 1998-06-10 (Released:2011-08-11)

参考文献数

14

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We developed safe and simple closed system for preparing ointments containing cytotoxic drugs using a polyethylene bag.β-Carotene (β-C) and fluorescein sodium (FL) were used as model drugs in the present study. All preparation procedures were carried out in a polyethylene bag. The uniformity of drug content in the ointment was obtained by rolling the contents more than 20 times with a roller in both model drugs. The contents of each model drug in the ointment prepared by a closed system were consistent with those by the conventional method using a glass mortar. The time required to prepare the ointment in a closed system was much shorter than that using the conventional method. In addition, no contamination was observed in the closed system, whereas some contamination of the cyto-safe sheet and gloves with FL were observed with the conventional method. Based on the present findings, a closed system using a polyethylen bag is thus considered to be a useful method for preparing ointments containing cytotoxic drugs.