著者

宮澤 紀子 栗原 昭一 浜屋 忠生 瀬山 智子 吉本 博明 江口 文陽

出版者

日本きのこ学会

雑誌

日本きのこ学会誌 : mushroom science and biotechnology (ISSN:13487388)

巻号頁・発行日

vol.21, no.1, pp.30-35, 2013-04-30

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キトサンは,きのこの細胞壁や甲殻類の外殻成分に含まれるキチンを脱アセチル化して得られる多糖類である.本研究では,エノキタケ由来のキトサン(キノコキトサン)の脂質異常症の改善効果および肥満抑制効果について肥満モデル動物であるZucker-fatty Ratを用いて検討した.キノコキトサンを与えた群では,体重の顕著な減少,肝臓への脂肪沈着の減少,糞便中の脂質含有率の増加を確認した.さらに血液生化学検査では,中性脂肪,総コレステロール,LDL-コレステロールの明らかな低下が認められた.キノコキトサンは,腸管からの脂肪吸収の抑制,脂肪細胞での脂肪分解を介した血中脂質の改善および肝臓組織への脂肪蓄積を顕著に抑制する作用を示し,肥満ならびにメタボリックシンドロームの改善に寄与することが示唆された.

著者

宮澤 紀子 栗原 昭一 浜屋 忠生 瀬山 智子 吉本 博明 江口 文陽

出版者

日本きのこ学会

雑誌

日本きのこ学会誌 (ISSN:13487388)

巻号頁・発行日

vol.21, no.1, pp.30-35, 2013-04-30 (Released:2018-03-15)

参考文献数

22

被引用文献数

1

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キトサンは,きのこの細胞壁や甲殻類の外殻成分に含まれるキチンを脱アセチル化して得られる多糖類である.本研究では,エノキタケ由来のキトサン(キノコキトサン)の脂質異常症の改善効果および肥満抑制効果について肥満モデル動物であるZucker-fatty Ratを用いて検討した.キノコキトサンを与えた群では,体重の顕著な減少,肝臓への脂肪沈着の減少,糞便中の脂質含有率の増加を確認した.さらに血液生化学検査では,中性脂肪,総コレステロール,LDL-コレステロールの明らかな低下が認められた.キノコキトサンは,腸管からの脂肪吸収の抑制,脂肪細胞での脂肪分解を介した血中脂質の改善および肝臓組織への脂肪蓄積を顕著に抑制する作用を示し,肥満ならびにメタボリックシンドロームの改善に寄与することが示唆された.

著者

近藤 敦 栗原 昭一 佐藤 紘子 石谷 邦彦

出版者

日本食生活学会

雑誌

日本食生活学会誌 (ISSN:13469770)

巻号頁・発行日

vol.14, no.3, pp.221-225, 2003-12-25 (Released:2011-01-31)

参考文献数

18

被引用文献数

1 3

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An inhibitory effect on the increase in the postprandial blood glucose level was evaluated with a test soft drink containing indigestible dextrin (ID). After 27 healthy volunteers consisting of 14 males and 13 females were given the test soft drink supplemented with ID (6g as dietary fiber) together with a 537 kcal starchy diet, blood glucose levels were determined at 30, 60, and 120 minutes after meal. Additionally, after the same subjects were given a control soft drink without ID together with the same starchy diet, blood glucose levels were determined to compare inhibitory effect on the increase in postprandial blood levels in a cross over experimental design. Subjects were first divided into two groups with a peak blood glucose level at 30 minutes and 60 minutes after meal and they were further divided into two groups the higher and lower blood glucose levels. The effects were comparatively evaluated with the respective subjects between the test and control soft drink ingesting periods.As a result, a clear significant inhibitory effect of the soft drink supplemented with ID on the postprandial blood glucose level in 23 subjects who showed a peak blood glucose level at 30 minutes after diet and 12 subjects who were apt to elevate their blood sugar levels (the former at p<0.05 and the latter at p<0.01). However, no significant effect was observed in 11 subjects who were hard to elevate their blood glucose levels. It is accordingly become clear that the test soft drink supplemented with ID has the inhibitory effect on the postprandial blood glucose level in subjects who were apt to elevate their blood sugar levels. No clear evaluation was made with subjects who showed their peak blood glucose levels at 60 minutes after meal because of the small number of replications of this group.As shown above, as the test soft drink supplemented with ID showed an inhibitory effect on the postprandial blood glucose level in healthy volunteers who were apt to elevate their blood glucose levels and it did not cause side reactions such as hypoglycemia or digestive disorders, it is suggested that the soft drink with supplemented with ID may be of great use as a safe and simple tea beverage to reduce the high postprandial blood glucose levels.