著者

采見 憲男 武田 節夫 北里 健二 梶原 大義 藤井 節郎

出版者

公益社団法人 日本化学療法学会

雑誌

CHEMOTHERAPY (ISSN:00093165)

巻号頁・発行日

vol.26, no.2, pp.200-208, 1978-03-25 (Released:2011-03-08)

参考文献数

13

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The antitumor activity of 1, 3-Bis (tetrahydro-2-furanyl) -5-fluoro-2, 4-pyrimidinedione (FD-1) was compared with that of 1- (2-Tetrahydrofuryl) -5-fluorouracil (FT) or 5-Fluorouracil (5-FU) in a number of tumor systems.FD-1 had significant activity against the solid forms but not the ascitic forms, and it produced a greater inhibition in tumor growth than FT. On AH 130 solid form, the therapeutic index (LD50/ED50) of FD-1 and FT were respectively 18. 3 and 10.6.FD-1 was evaluated against the ip and sc implanted L 1210 leukemia by single, intermittent or daily administration. FD-1 retained some degree of antileukemic activity against the ic implanted L 1210.No significant difference in antitumor activity was observed between the R and S isomers or the racemic mixture (FD-1).A higher activity of FD-1 compared to FT was possibly due to the increased 5-FU level in tumor through its metabolite, 3- (tetrahydro-2-furanyl) -5-fluoro-2, 4-pyrimidinedione (3-FT).

著者

瀧川 勝雄 国分 信彦 梶原 大義 土肥 美恵 田原 溶夫

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.68, no.4, pp.489-493, 1972 (Released:2010-07-30)

参考文献数

28

被引用文献数

15 15

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Using rabbits and rats injured in experimental Whiplash, changes in glycolysis and enzyme activities of the cervical cords, and the effects of Pantui extracts, Pantocrin were investigated in detail. In the cervical cords, depressed glycolysis and lowered activities of aldolase, GOT, and alkaline phosphatase were noted. Cervical injuries were greater in rats than rabbits while hexokinase, glycerokinase and GPT were inhibited. Three enzymes in the rabbits were also inhibited. This enzymological difference between the two species appeared to be dependent on the extent of injury. Pantocrin remarkably improved abnormal glycolysis and the lowered enzyme activities of cervical cords from both injured animals.