1 0 0 0 OA 気管支喘息における血中セロトニン値の動態と関連諸因子に関する研究
- 著者
- 森下 淳夫
- 出版者
- 特定非営利活動法人 日本気管食道科学会
- 雑誌
- 日本気管食道科学会会報 (ISSN:00290645)
- 巻号頁・発行日
- vol.29, no.3, pp.198-207, 1978-06-10 (Released:2010-02-22)
- 参考文献数
- 32
The blood serotonin level was measured in 144 subjects consisting of 23 normal subjects, 84 patients with bronchial asthma, 13 with nasal allergy, 16 with other pulmonary diseases and 8 with urticaria. In asthmatic patients, the data were specifically examined with reference to the other clinical and laboratory test results. The results were as follows;1. The blood serotonin level in 23 normal subjects was within the range of 0.081±0.02μg/ml and there was no sexual difference.2. The blood serotonin level was 0.108±0.027μg/ml in asthmatic patients, 0.120±0.013μg/ml in nasal allergy and 0.113±0.023μg/ml in urticaria. These values were signifantly higher than that in the normal subjects (p<0.01). The value in other pulmonary diseases tended to be higher than the normal but the difference was statistically insignificant.3. Among different types of asthma, atopic type showed significantly higher blood serotonin level than the others (p<0.01). When the measurement was made in the subjects during their asthmatic attack, the value was evidently higher than in those in attack-free interval. In particular, the difference was statistically significant if the comparison was made within the same subject (p<0.01).4. The blood serotonin level in the group showing positive skin reaction to allergen was higher than that in the negative group (p<0.001). However, there was no positive correlation between the blood serotonin level and serum IgE or the blood histamin level.5. The blood serotonin level in type I and type II groups of CMI test was higher than that in type III and type IV groups (p<0.02). On the other hand, the results of Yatabe-Gilford test showed no positive correlation with the blood serotonin level.6. There was a tendency toward decreasing blood serotonin level following the treatment with β-stimulator and corticosteroid. However, there was no change in the blood serotonin level by hyposensitization or gold therapy.