著者

落合 明子 飯田 桂 髙部 浩行 川村 恵里 佐藤 康彦 加藤 保富 大熊 盛之 檀上 和美

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.70, no.6, pp.324-331, 2010 (Released:2019-03-08)

参考文献数

18

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Latanoprost tends to degrade in an aqueous solution, and also adsorbs to the plastic containers. Moreover, the latanoprost content of the formulation can easily degrade, depending on the storage temperature, because of the very low drug concentration in the eye drops. Therefore, Xalatan® Eye Drops should be stored at 2-8°C (in the refrigerator)for the reasons described above.In this study, we investigated ways to improve the stability of latanoprost in aqueous solution in order to develop a formulation of latanoprost eye drops that can be stored at room temperature (1-30°C). Excipients used for opthalmological preparations were examined. The stability at 60°C was evaluated after 4 weeks in model formulations that included the excipient, which enables sterile filtration. As a result, the latanoprost content was not decreased in formulations that included polyoxyl 40 stearate and polyethylene glycol monostearate 25 at suitable concentrations. Then, we established a formulation of latanoprost eye drops that could be stored at room temperature. It was assumed that both the degradation of latanoprost and adsorption to the plastic containers were depressed by these excipients.The formulation developed in this study would not need to be stored in the refrigerator either during the medication period of the patient or during distribution and storage at medical sites. It was also predicted that instructions on the use of these drugs would be simplified. Therefore, the latanoprost eye drops developed in this study would be very useful for patients and health care professionals.

著者

飯田 耕太郎 LEUENBERGER Hans FUEG Lise-Marie Muller-WALZ Rudi 檀上 和美

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.119, no.10, pp.752-762, 1999-10-01

被引用文献数

5

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Most often dry powder for inhalation are formulated as ordered mixtures of a carrier excipient and a micronized drug substance. In the present study, model powder blends were prepared from a mixture of lactose α-monohydrate, microcrystalline cellulose pellets or synthesized sugar as carrier particles, and micronized salbutamol sulfate (SS). These ordered mixtures were aerosolized by the multidose JAGO dry powder inhaler (DPI) and their in vitro deposition properties were evaluated by a twin impinger (TI). The separation force between SS particles and carrier particles was investigated by the centrifuge method. In addition, the use of the air jet sieve (AJS) method was investigated to assess the separation behavior of drug particles from carrier excipient. Powder blends were sieved through a 325 mesh wire screen of an air jet sieve at an air pressure of 1500 Pa. The amount of drug deposited at the carrier surface was analysed before and after the sieving to calculate the percentage of the drug retained. A relationship was found between in vitro deposition properties (fine particle fraction, FPF) and the separation characteristics obtained by the centrifuge method and by the AJS method. The AJS method might be a suitable alternative for evaluating separation of a drug particle from carrier particles and hence can be used for the formulation screening of the dry powder inhalation.

著者

檀上 和美 神谷 明良 池田 栄司 鳥居 佐紀子 砂田 久一 大塚 昭信

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.9, pp.2505-2509, 1992-09-25

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In the present study, a water/isopropyl alcohol system was selected as the solvent in a hydroxypropylcellulose (HPC) binder solution for the preparation of lactose granules.With a fluidized bed granulation method, the mean granule diameter increased as the adhesion tension (γcosθ) and lactose solubility increased. With an agitating granulation method, the mean granule diameter was independent of the adhesion tension and lactose solubility, but it increased as the viscosity of the binder solution increased.With both granulating methods, greanule hardness increased as the adhesion tension and lactose solubility increased, while the pore volume of the granules decreased as the adhesion tension and lactose solubility increased.The quantitative relationship between the physical properties of the granules and several properties of the solvent solution was investigated by the application of multiple regression analysis.