著者

喜友名 朝則 喜瀬 乗基 真栄田 裕行 又吉 宣 比嘉 麻乃 鈴木 幹男

出版者

日本喉頭科学会

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.28, no.1, pp.24-30, 2016-06-01 (Released:2016-10-28)

参考文献数

38

被引用文献数

3

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A laryngeal papilloma is a benign tumor that occurs due to human papilloma virus infection. Although basically benign, the lesions often recur and grow in size. Furthermore, they sometimes show malignant transformation and often suffer from treatment. We performed a retrospective clinical analysis of 15 patients with laryngeal papilloma who were treated at our department over the past ten years. As with previous reports, most cases involved adult males and occupied the glottis. Canceration only occurred in one patient. Human papilloma virus infections were detected in 14 patients. All of the cases involved with type 6 or type 11(benign types)infections. Canceration occurred in one patient who did not show infection. The treatments performed at our center included, surgical resection and/or transpiration by a CO2 laser. Recurrence was observed in some cases. This was treated with multiple surgeries. Remission was achieved by the combination of treatment under local anesthesia and adjuvant therapy. It is difficult to cure laryngeal papilloma radically because it is a viral disease. Thus, we treat the disease as follows; we first confirm the lesion with a laryngeal endoscope under general anesthesia and perform a biopsy; and then conduct resection and/or transpiration using CO2 laser. When recurrence is observed, we immediately attempt extraction or laser transpiration under local anesthesia while the lesion is small. As the number of cases increases, it will be necessary to examine surgical method and postoperative adjuvant therapies.

著者

喜友名 朝則 真栄田 裕行 比嘉 麻乃 鈴木 幹男

出版者

日本喉頭科学会

雑誌

喉頭 = The Larynx Japan (ISSN:09156127)

巻号頁・発行日

vol.24, no.1, pp.1-5, 2012-06-01

参考文献数

15

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Objective : The aim of the present study is to clarify central phonation control during high pitch vocalization.<BR>Subjects and methods : The participants were 16 right-handed, healthy adults. Functional magnetic resonance imaging (fMRI) was employed to detect brain activity in response to vowel phonation (&frasl;i:&frasl;) with high pitch. The sparse sampling method for MRI scanning was used to reduce body movement artifacts due to phonation and acoustic artifacts due to scanner noise. The brain activity in response to phonation with comfortable pitch as well as high pitch was measured using the statistic parametric mapping 5 software.<BR>Result : Brain activation specific to high pitch phonation was observed in the anterior cingulate cortex and cerebellum. There was however no specific motor cortex activity during high pitch phonation.<BR>Conclusion : In the central phonation control system proposed by Symonyan et al, subsystem II (periaqueductal gray matter, anterior cingulate cortex, and limbic input structures) is involved in regulating vowel phonation with high pitch.