著者

福田 裕子 田中 裕貴子 森田 貴子 中永 あやこ 道下 佳子 中蔵 伊知郎 北澤 文章 辻川 正彦

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.47, no.5, pp.264-271, 2021-05-10 (Released:2022-05-18)

参考文献数

19

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We experienced two cases with mild to moderate renal dysfunction in which amantadine hydrochloride (amantadine) intoxication was followed by increases in its blood levels. Case 1 was a patient with mild to moderate renal dysfunction [estimated glomerular filtration rate (eGFRcreat): 48.9 mL/min/1.73m2; glomerular filtration rate (GFR) category: G3a] taking amantadine 300 mg daily. In Case 1, the blood level of amantadine at 13 hours and 30 mins after administration was 2,368 ng/mL, pyrexia, myoclonus, and psychological symptoms were observed. After discontinuing amantadine, the patient’s myoclonus improved, but he died of acute respiratory distress syndrome. Case 2 was a patient with mild to moderate renal dysfunction [eGFRcreat: 55.6 mL/min/1.73m2; GFR category: G3a] taking amantadine 100 mg daily. In the patient, pyrexia, myoclonus, and consciousness disorder were observed. The blood level of amantadine 88 hours after the last dose was 265 ng/mL, and the blood level that was collected 24 hours after the end of administration was estimated to be about 2,600 to 4,200 ng/mL. In all cases, the clinical features were consistent with the common symptoms of amantadine intoxication, and improved by discontinuing amantadine. Taken together, these findings suggest that the patients were intoxicated with amantadine. These results indicate that amantadine intoxication due to elevated blood levels also occurs in patients with mild to moderate renal dysfunction during the administration of the usual dose of amantadine. In addition, the measurement of amantadine blood levels may be useful in avoiding amantadine intoxication.

著者

田中 裕貴 加藤 博明

出版者

公益社団法人 日本化学会・情報化学部会

雑誌

ケモインフォマティクス討論会予稿集 第31回情報化学討論会 東京

巻号頁・発行日

pp.P14, 2008 (Released:2008-11-06)

参考文献数

3

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化学物質の種々の性質はその化学構造と密接に関連していることがよく知られている。本研究では、分子におけるヘテロ原子の局所的な空間配置に注目し、ヘテロ原子間の三次元距離情報をもとに生成した最小全域木(ヘテロツリー)を定義した。CSDから抽出した一群の化合物データに対してヘテロツリーの生成を行い、その出現頻度を求めるとともに、特徴的なヘテロツリーパターンと活性との相関についても調査を試みている。