著者

白土 明子 中西 義信

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.126, no.12, pp.1245-1251, 2006-12-01 (Released:2006-12-01)

参考文献数

29

被引用文献数

4 5

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Infection with a variety of viruses induces apoptosis in host cells. This phenomenon may be considered to be a self-defense mechanism to avoid viral propagation. However, the growth of influenza virus is completed before host cells become dysfunctional due to apoptosis. To clarify the physiologic consequences of influenza virus-induced apoptosis, the fate of influenza virus-infected cells was examined in vitro as well as in vivo. Influenza virus-infected cells were engulfed by macrophages in vitro, and virus propagation was almost completely inhibited. This phagocytosis was dependent on the specific recognition of the membrane phospholipid phosphatidylserine exposed on the surface of virus-infected apoptotic cells by macrophages. In addition, the activity of viral neuraminidase expressed at the surface of virus-infected cells was necessary for the maximal level of phagocytosis. When mice infected with influenza virus were administered phagocytosis inhibitors, the level of lethality and inflammation in the lung were augmented. These results show that apoptosis makes influenza virus-infected cells susceptible to phagocytosis by macrophages, and that this leads to a reduction in the extent of influenza pathology.

著者

白土 明子 中西 義信

出版者

公益社団法人 日本油化学会

雑誌

オレオサイエンス (ISSN:13458949)

巻号頁・発行日

vol.9, no.10, pp.465-471, 2009 (Released:2013-06-01)

参考文献数

18

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私たちの一生を通じて, 多くの細胞が生理学的細胞死のアポトーシスを起こし, 速やかに貧食を受けて生体から除去される。このアポトーシス細胞の貧食除去は, 生体恒常性の維持に必要である。膜リン脂質はこの現象に関与し, 標的細胞が食細胞に認識される際の目印や食細胞中での貧食誘導性情報伝達の制御因子として働くことが知られる。本稿では, 膜リン脂質に依存したアポトーシス細胞貧食反応の仕組みと意義とを解説する。