著者

田中 博之 有山 智博 石井 敏浩

出版者

一般社団法人 日本皮膚アレルギー・接触皮膚炎学会

雑誌

日本皮膚アレルギー・接触皮膚炎学会雑誌 (ISSN:18820123)

巻号頁・発行日

vol.10, no.3, pp.195-201, 2016-07-30 (Released:2016-09-01)

参考文献数

22

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日本における薬剤性光線過敏症の発症状況を把握する目的で,日本の有害事象自発報告データベース(JADER)を用いて薬剤性光線過敏症症例の調査を行った。 JADERに登録された症例のうち,“光線過敏性反応”,“日光皮膚炎”,“光線性皮膚症”および“光線性口唇炎”が報告された症例を対象とし,患者背景,使用薬剤,発症日,転帰を解析した。 総報告件数は293件(男性 : 160件,女性 : 133件)であり,年齢は60歳代が75件,70歳代が83件と高齢者が多かった。被疑薬はロサルタンカリウム・ヒドロクロロチアジドが72件と最も多く,次いでケトプロフェンが25件であった。発症月は4~8月に集中する傾向があった。多くは回復または軽快するが,なんらかの障害が残る症例も確認された。 本調査より,薬剤性光線過敏症の発症状況が明らかとなった。これらの知見は薬剤性光線過敏症の予防や治療の一助となると考えられる。

著者

田中 博之 篠原 悦子 佐藤 光利 石井 敏浩

出版者

Japanese Society of Drug Informatics

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.18, no.1, pp.1-6, 2016 (Released:2016-06-13)

参考文献数

22

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Objective: The aim of this study was to review cautionary statements regarding hypersensitivity to drugs with a moiety similar to sulfonamide on Japanese package inserts.Methods: From approved drugs listed as of March 2015, we selected those with a moiety similar to sulfonamide and examined their therapeutic categories, together with the presence or absence, location, and wording of cautionary statements regarding usage, and matters pertaining to a history of drug hypersensitivity that was not limited to sulfonamide, on the package inserts.Results: We extracted 73 drugs (65 components) that included a moiety similar to sulfonamide.  Their therapeutic categories were diverse, and 39 (53.4%) had cautionary statements about hypersensitivity caused by a moiety similar to sulfonamide.  Among these 39 drugs, the cautionary statements were located in different sections (Contraindication 31, Careful Administration 4, and Important Precautions 4).  The cautionary statements showed differences in wording according to the individual drugs or positions.  For 10 of the drugs, information pertaining to a history of drug hypersensitivity not limited to sulfonamide was provided.Conclusion: Medical staff should recognize that package inserts are not standardized with regard to cautionary statements about hypersensitivity caused by moieties similar to sulfonamide, and that it is necessary to predict or judge the likelihood of cross-hypersensitivity reaction to such moieties on the basis of their chemical structure.  In addition, it is necessary to carefully observe the clinical condition of individual patients who are receiving drugs that have a moiety similar to sulfonamide.

著者

小野田 稔久 木下 雅子 田中 博之 井澤 香 浦野 敦 佐藤 直子 増田 雅行 石井 敏浩

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.142, no.11, pp.1267-1276, 2022-11-01 (Released:2022-11-01)

参考文献数

19

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During the treatment of cardiogenic shock, various continuous infusion drugs are used simultaneously. However, administration from the same route may result in stability changes due to mixing of drugs. In addition, stability tests after mixing more than three types of drugs have hardly been conducted. In this study, noradrenaline, milrinone, dobutamine hydrochloride, and landiolol hydrochloride were used to evaluate the chemical stability of the mixture. Chemical stability was evaluated by measuring the change in each drug concentration over time and calculating the content. The concentration of each drug was measured using an optimized gradient elution method by HPLC. In a four-drug mixed sample, noradrenaline, milrinone, dobutamine hydrochloride, and landiolol hydrochloride had retention times of 2.1 min, 5.2 min, 9.3 min, and 11.9 min, respectively. The concentration immediately after mixing each drug was almost the same as the theoretical concentration at the time of mixing each drug. Furthermore, noradrenaline, milrinone, and dobutamine hydrochloride concentrations were maintained up to 99% in each drug mixture until 24 h after mixing all the samples. However, the content of landiolol hydrochloride was 90% or less 24 h after mixing, except for two types of mixed solutions with dobutamine hydrochloride. This result suggested that landiolol hydrochloride was being degraded owing to acidic conditions. The results of this study suggest that noradrenaline, milrinone, and dobutamine hydrochloride can be administered from one route, while it is recommended that landiolol hydrochloride be administered from another route.