著者

黒木 祐吾 岡本 喜之 石橋 真乃介 川田 賢介 石川 好美

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.1, pp.9-15, 2015-04-01 (Released:2015-06-01)

参考文献数

15

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Hunter glossitis is a relatively rare disease caused by vitaminB12 deficiency. We clinically studied six cases of Hunter glossitis caused by vitamin B12 deficiency. All cases complained tongue pain and dysgeusia, and they showed atrophy of lingual papillae and vitamin B12 deficiency in blood examination. Macrocytic anemia was found out in five cases but one case was not anemia. Two cases were under treatment of chronic gastritis and three cases were total gastric resection in past. Untreated atrophic gastritis was found out in one case by upper gastrointestinal endoscopy. We treated all cases by oral administered vitamin B12 therapy 1500 µg/day. After this therapy, red smooth tongue, oral pain, dysgeusia and level of vitamin B12 in blood were improved in all cases. It is popular that the treatment of vitamin B12 deficiency is based on parenteral vitamin B12 administered intramuscular injection. But recently, a few reports documented positive results following oral vitamin B12 therapy. As the result of these cases, oral administered vitamin B12 therapy was effective to Hunter glossitis.