著者
加來 洋子 枝並 宏治 福本 雅文 山口 雅巳 渋谷 鉱
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.27, no.2, pp.116-124, 2008-08-01 (Released:2010-06-08)
参考文献数
27

We conducted a study of judicial decisions on medical accidents covered between 1994 and 2000 by the Japanese press and Hanrei Times, a Japanese magazine specializing in judicial precedents, to obtain information on drug package inserts, and the extent to which these inserts are used as criteria for the judicial decisions.During the period studied, judicial decisions were issued regarding 514 cases of medical accidents, and a total of 1, 238 articles covering the decisions were published in the media referred to above. Looking at the changes in the number of cases by year, there were between 51 and 81 cases yearly from 1994 through 1999, while this number significantly increased in 2000, to 121.Out of the 514 cases, 34 (6.6%) were associated with drugs; drug package inserts were used as criteria for the decisions in four of the 34 cases, and 19 articles covering these four cases were carried in the media. Meanwhile, in 374 of the 514 cases (72.8%), it was judged that medical care personnel were to blame for the accidents, and these cases were covered in 1, 010 of the 1, 238 articles (81.6%) in the media.Common cases of malpractice pointed out to doctors and other medical personnel included violation of due care in terms of drug package inserts. Furthermore, a link between medical practice and the level of medical care was also indicated, as well as a link between package inserts and the level of medical care. The level of medical care varies due both to differences in medical services and the individual circumstances surrounding medical care providers, and negligence in collecting the latest information for medical findings is also included among the various types of malpractice.Other cases of malpractice included violations of accountability, in which medical care personnel neglected to inform patients of items mentioned in drug package inserts.Doctors, dentists, and other medical personnel must fully understand the descriptious given in drug package inserts.
著者
長嶋 友美 東海 林徹 中村 郁子 遠藤 泰 米澤 裕司 竹野 敏彦 小松﨑 康文 山﨑 浩 鬼頭 健二 田中 秀弥 山根 理恵子 村井 久美 池田 幸 斎藤 義夫 遠山 邦子 花岡 平司 鵜飼 孝子 外尾 典子 上中 清隆
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.35, no.1, pp.16-26, 2016 (Released:2016-05-10)
参考文献数
18

The purpose of the present study was to survey the use of antibacterial agents at 18 private dental college or university hospitals in Japan, as performed approximately every 10 years since 1983, and to identify the diseases treated with these medicines for longer than eight days at these dental hospitals. We first calculated the amount of antibacterial agents prescribed in October 2013. For internal and external preparations, almost all antibiotics comprised cephems (68%, 64%), penicillins (23%, 25%) and macrolides (7%, 8%), with values expressed in terms of percentage for outpatient and inpatient treatments, respectively, and these values were similar to previous surveys. The ratio of internal and external preparations was nearly six-fold higher when compared with injections. About 70% of oral cephems administrated to both outpatients and inpatients was cefcapene pivoxil hydrochloride. In contrast, the antibacterial injection administered to inpatients was primarily cefazolin sodium and that to outpatients was primarily ceftriaxone sodium hydrate. The ratio of carbapenems was less than 1%. Among the antibacterial agents administered for longer than eight days, clarithromycin was mainly used for the treatment of odontogenic chronic sinusitis. Our study suggested that clarithromycin was used appropriately in long-term treatment for chronic diseases. However, we found that a limited variety of oral cephems were heavily used for short-time administration, which might lead to the emergence of resistant bacteria. Pharmacist information and advice may be helpful for dentists to avoid it because proper pharmaceutical management of antibacterial agents is essential for the prevention of resistant bacteria.
著者
金坂 伊須萌 金山 明子 中西 康大 鈴木 崇嗣 金子 明寛 小林 寅喆
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.34, no.3, pp.100-105, 2015 (Released:2015-12-25)
参考文献数
18

We conducted a study about the antimicrobial susceptibility to ceftriaxone(CTRX)and prevalence of the genes cfxA/cfxA2 of clinical isolated Prevotella strains. Furthermore, we performed in vitro study for effects on the antibiotic treatment by mixed culture of β-lactamase producing Prevotella and Streptococcus mitis. All Prevotella isolates resistant to CTRX(MIC ≧32μg/mL)were found possess the cfxA/cfxA2. Prevalence of cfxA/cfxA2 of Prevotella isolates classified as susceptible by CLSI guidelines showing a MIC of ≦0.5μg/mL were less than 25% and a MIC of 1-16μg/mL were more than 73%. Viable cells of S. mitis showed more than 99% decrease in culture broth with CTRX at a concentration of 5μg/mL for up to 8 hours. In mixed culture of ESBL producing Prevotella oralis and S. mitis, viable cells of S. mitis was increased slightly in the presence of CTRX. The decrease of viable counts in S. mitis was not seen in the case of mixed culture of ESBL-producing P. oralis and S. mitis in the presence of CTRX at a concentration of 5μg/mL for up to 8 hours.   In conclusion, the cases of mixed infection with Prevotella and Oral Streptococci, it was suggested that the Prevotella producing ESBL caused an indirect pathogen for odontogenic infection.
著者
小野 眞紀子 大野 奈穂子 長谷川 一弘 田中 茂男 小宮 正道 松本 裕子 藤井 彰 秋元 芳明
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.27, no.2, pp.79-85, 2008-08-01 (Released:2010-06-08)
参考文献数
34
被引用文献数
2

15種類のカルシウム拮抗薬による歯肉増殖症発生頻度を検討した.歯肉増殖症はamlodipine, diltiazem, manidipine, nicardipine, nifedipineおよびnisoldipine服用者に認められたが, azelnipine, barnidipine, benidipine, efonidipine, felodipine, flunarizine, nilvadipine, nitrendipineおよびverapamil服用者にはみられなった.最も高い発生頻度はnifedipine (7.6%) であり, diltiazem (4.1%) , manidipine (1.8%) , amlodipine (1.1%) , nisoldipine (1.1%) , nicardipine (0.5%) の順であった.Nifedipineによる歯肉増殖症発生頻度は, amlodipine, manidipine, nicardipine, nisoldipineの発生頻度と比較して有意に高かった.
著者
郡司 敦子 郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.28, no.3, pp.109-116, 2009-12-01 (Released:2010-04-16)
参考文献数
39
被引用文献数
1

Acetaminophen is an antipyretic and analgesic drug that has a long history of 100 years or more and has been adopted in the WHO Model List of Essential Drugs in the category of non-opioids and non-steroidal anti-inflammatory medicines. In Japan, the analgesic effects of acetaminophen have not been sufficiently recognized, and NSAIDs have been used in the treatment of pain, even though acetaminophen is the first-choice analgesic worldwide.Since acetaminophen, which is different from NSAIDs, does not inhibit the activity of COX-1 and COX-2, the risk of developing the 3 well-known adverse reactions of NSAIDs, peptic ulcer and gastrointestinal hemorrhage, renal dysfunction, and hemorrhage and platelet dysfunction, is very low. Aspirin is known to induce asthma and Reye's syndrome, however, acetaminophen is scarcely associated with these adverse reactions and can be used for treatment of viral diseases such as chicken pox and influenza. The safety of acetaminophen in pregnant women and elderly patients has been confirmed, and the position of acetaminophen as the first-choice analgesic drug has been established worldwide. In Japan, on the other hand, the effect of acetaminophen has not been sufficiently recognized due to the small doses (single dose, 300-500 mg; daily dose, 900-1500 mg/day) compared to other nations (single dose, 1,000 mg; daily dose, 4000-6000 mg/day). Further, the precautions for use indicated in the package insert of acetaminophen are the same as that indicated for NSAIDs; this may be a possible reason why acetaminophen has been misunderstood to be a kind of anti-inflammatory medication (NSAIDs) in Japan.From above-mentioned viewpoint, the dosage of acetaminophen and expression of the precautions in packaging insertion should be reconsidered. The dosage of acetaminophen as a nonprescription drug should also be reconsidered because the dosage in OTC is further lower than that of the prescription drug. It is expected that when a more reliable analgesic effect is obtained by the administration of a higher dosage of acetaminophen and a more accurate profile of its safety is recognized, this drug will become the first-choice analgesic in Japan.
著者
中川 洋一
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.35, no.1, pp.28-34, 2016 (Released:2016-05-10)
参考文献数
49
被引用文献数
3

A global consensus regarding the terminology of dry mouth is needed in order to facilitate diagnosis and treatment as well as future research and education. This review summarizes the terms concerning dry mouth, including : xerostomia, hyposalivation, altered salivary composition, salivary gland dysfunction, and salivary dysfunction.
著者
金子 明寛
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.34, no.3, pp.85-93, 2015 (Released:2015-12-25)
参考文献数
27
被引用文献数
5

A number of odontogenic infections are often alleviated in a few days if inflammation is localized in the alveolar part, and appropriate surgical treatments such as incision or drainage as well as antibacterial chemotherapy are performed. However, in some cases, it may become desperately ill due to delay of the initial treatment and develop extremely serious infections including cellulitis or necrotic fasciitis. The causative bacteria for these diseases are oral resident microbiota, and are frequently detected in the case of multiple bacterial infection caused by obligate and facultative anaerobic bacteria. From odontogenic infection, Prevotella sp., Peptostreptococcus sp., and Streptococcus sp. are detected at high rate and are regarded as the three major etiologic agents. The change with time in susceptibility of strains separated from closed abscess of odontogenic infection during 7 years from 2005 to 2011 against various antibacterial agents was investigated. The results showed a decreasing tendency of susceptibility to β-lactam, macrolide, and quinolone agents. In particular, there are many β-lactamase producing strains in the Prevotella sp. Thus, it is necessary to select antibacterial agents stable for β-lactamase in patients with suspected involvement of obligate anaerobic bacteria such as cellulitis around the maxilla or deep neck abscess.
著者
荻原 和孝 小川 智久 浅木 信安 沼部 幸博 鴨井 久一
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.15, no.3, pp.130-136, 1996-12-01 (Released:2010-06-08)
参考文献数
19

Aqua oxidized water (AOW) and Aqua alkalic water (AAW) are made by acidic electrolyzed water making equipment; OXILIZER (OXILIZER Co., Tokyo, Japan) . AOW is acidic water with a pH under 2.7 and is processed by electrolysis through a small NaCl mediated specific membrane. It was over 1, 100mV of oxidation-reduction potential and includes Cl2, OH⋅, O3, ClO. AAW is alkalic water with pH 11.AOW has a strong bactericidal effect on bacteria and virus but the effect is reduced by the large number of organisms. It has a metallic corrosive function as well as an organic matter action. There are few reports about AAW sterilizing without a metallic corrosive action. The bactericidal effect of AAW to periodontopathic bacteria [Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn) ] and Staphylococcus aureus (Sa) and Escherichia coli (Ec) was investigated. The bactericidal effect of AOW and AAW were compared.Bacterial strain Sa : 209-P, Ec : B, Aa : Y4 and ATCC 29522, Pg : 381 and ATCC 33277, Pi : 25611, Fn : 25586 were grown at 3TC in BHI (aerobic and anaerobic condition), GAM contained hemin, menadion and yeast (anaerobic condition), and GAM broth (anaerobic condition), respectively. After washing by centrifugation, each bacteria was suspended in PBS.Serum and saliva were obtained from one healthy volunteer.Bactericidal activity was measured by colony count seeding and grown on BHI or Anaero columbia blood agar or GAM medium after treatment with AAW or AOW.The results were as follows:1. Bactericidal effect and effective concentration of AAWAa, Pg, Pi were killed in one minute (Aa; 108 to 104 CFU/ml, Pg; 108 to 103 CFU/ml, Pi ; less than 108 to 103 CFU/ml) from original 100% AAW, while it took more than one minute to kill Fn, and Sa and Ec had survived after ten minutes. Further, sterilizing activity decreased with AAW' s dilution. AOW shows that a 25% concentration is most effective against periodontopathic bacteria.2. The effect of saliva and serum on bactericidal activity of AAWAs for Aa, Pg and Pi, the addition of saliva or serum in a concentration of 1% of AAW had decreased bactericidal activity slightly. However, the bactericidal activity was completely negated by the addition of 10% serum of AAW. As for Fn, the bactericidal activity was negated in 1% of serumor salivery addition.
著者
石塚 恭子 田中 健二郎 竹内 俊充 長澤 恒保 戸苅 彰史
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.36, no.3, pp.81-88, 2017 (Released:2017-12-27)
参考文献数
75

Fracture risk increases substantially with age due to decreased bone density and muscle mass, and also problems with vision and balance. In the elderly, medication used to treat non-skeletal disorders is one of the causes of bone fracture accompanying decreased QOL. Increased fracture risk by medication is based on either adverse drug reactions on bone metabolism or adverse drug events such as falls. The use of fall risk-increasing drugs (FRIDs), such as opioids, dopaminergic agents, anxiolytics, antidepressants and hypnotics/sedatives, have been demonstrated to increase risk of fracture. Furthermore, in addition to FRIDs, many drugs have been found to affect bone mass and fracture risk as a result of the side effects on bone metabolism. The present article reviews the current understanding of several drugs influencing fracture risk. In particular, drugs affecting fracture risk through sympathetic neuronal activity are also discussed.
著者
王 宝禮 砂川 正隆 山口 孝二郎 亀山 敦史 金子 明寛
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.34, no.1, pp.23-30, 2015-04-01 (Released:2015-06-01)
参考文献数
46

Kampo medicine has a long experience and actual performance over a long period of history. The first oriental medicine was approved by Japanese national health insurance in 1976, and 147 kinds of oriental medicine are currently approved by the National Health Insurance Drug Price. Those of 7 kinds of Kampo medicine were approved by Japan Dental Association of “National Health Insurance Drug Price Standard related with dental treatment” on April 2012. It has been reported that approximately 70 to 80% of doctors has an experience to use oriental medicine in a clinical site. Meanwhile, oriental medicine was used at more than 85% of medical facilities in a survey of Kampo medicine usage at oral surgery clinics in all Japanese Dental University hospital and Medical University hospital. However, only a few Kampo medicine was used at general dental clinics. Establishment of the evidence of oriental medical treatment in dental lesions is one of the solution of popularizing a treatment of Kampo medicine in oral surgery. Hence, efficacy of Kampo medicine which was approved by the new drug standard since 1986 was evaluated from the aspect of Evidence-based medicine(EBM).
著者
森 紀美江 大野 康亮 山本 麗子 根本 敏行 道 健一
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.11, no.3, pp.180-183, 1992-12-01 (Released:2010-06-08)
参考文献数
13

This has been a report of headache as side effects after administration of antimicrobial agent. We encountered two cases. Case 1 was diagnosed as having chronic mandibular osteomyelitis. Cefteram pivoxil (CFTM-PI) was administrated to this patient in three 200 mg doses daily, one dose after each meal. The patient complained of a headache 2 to 3 hours after receiving the initial dose of 200mg.Case 2 was diagnosed as possibly having postoperative infection. Roxithromycin (RU28965) was given in two 150 mg doses daily after breakfast and dinner for 4 days. This patient complained of a headache after the initial dose of 150mg, and it lasted for 4 days.In these two cases, appearance of the headache occurred at about the time of maximum serum level.We report these cases, because there have been few reports of headache as a side effect of these antibiotics.
著者
TAKEYA YAMADA KAZUHISA BESSHO KENICHIRO MURAKAMI SHINSUKE HORI TADAHIKO IIZUKA NATSUKI SEGAMI
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
ORAL THERAPEUTICS AND PHARMACOLOGY (ISSN:02881012)
巻号頁・発行日
vol.17, no.1, pp.18-22, 1998-04-01 (Released:2010-06-08)
参考文献数
20
被引用文献数
3

This study was conducted to asses the clinial efficacy of Sai-boku-to (Kanpo) in comparison to minor tranquilizer with vitamin B complex medication for the treatment of glossodynia.Either Sai-boku-to (7.5g per day) of minor tranquilizer (Diazepam) 6mg per day with vitamine B complex medication for three months was P. O. administered to 104 cases. The clinical examination was carried out in order to evaluate the subjective symptoms such as pain, heat sensation, and unpleasent feeling in comcomitant treatment of glossodynia.After three-month administration the success rates were 75.8 %, 87.1 %, and 88.7 % in the Sai-boku-to medication group and 73.8 %, 71.4 %, 69.0 % in the minor tranquilizer medication group. The Sai-boku-to medication group was significantry superior to the minor tranquilizer medication group. The side effect of the sleepiness was found in 13 cases in the minor tranquilizer medication group. On the contrary, a mild signs and symptoms of digestive discomfort was noted in three cases in the Sai-boku-to medication group.These results suggested that Sai-boku-to was a clinically useful drug for the treatment of glossodvnia.
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.18, no.3, pp.182-183, 1999-12-01 (Released:2010-06-08)
参考文献数
6
著者
半場 道子
出版者
日本歯科薬物療法学会
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.18, no.3, pp.156-164, 1999-12-01 (Released:2010-06-08)
参考文献数
29
著者
服部 孝範 古賀 賢三郎 可知 久志 後藤 学 田中 悟 成田 秀貴 生川 哲也 河合 幹
出版者
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY
雑誌
歯科薬物療法 (ISSN:02881012)
巻号頁・発行日
vol.1, no.1, pp.6-8, 1982-12-31 (Released:2010-06-08)
参考文献数
3

Agar well method was compared with cup method. Diameter of inhibition zone of Agar well method was smaller than diameter of inhibition zone of cup method.Diameter of inhibition zone of Agar well method was almost same size and the measured value of Agar well method was low in aberration.