著者

川辺 良一

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.35, no.1, pp.40-48, 2016 (Released:2016-05-10)

参考文献数

4

著者

郡司 敦子 郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.28, no.3, pp.109-116, 2009-12-01 (Released:2010-04-16)

参考文献数

39

被引用文献数

1

---

Acetaminophen is an antipyretic and analgesic drug that has a long history of 100 years or more and has been adopted in the WHO Model List of Essential Drugs in the category of non-opioids and non-steroidal anti-inflammatory medicines. In Japan, the analgesic effects of acetaminophen have not been sufficiently recognized, and NSAIDs have been used in the treatment of pain, even though acetaminophen is the first-choice analgesic worldwide.Since acetaminophen, which is different from NSAIDs, does not inhibit the activity of COX-1 and COX-2, the risk of developing the 3 well-known adverse reactions of NSAIDs, peptic ulcer and gastrointestinal hemorrhage, renal dysfunction, and hemorrhage and platelet dysfunction, is very low. Aspirin is known to induce asthma and Reye's syndrome, however, acetaminophen is scarcely associated with these adverse reactions and can be used for treatment of viral diseases such as chicken pox and influenza. The safety of acetaminophen in pregnant women and elderly patients has been confirmed, and the position of acetaminophen as the first-choice analgesic drug has been established worldwide. In Japan, on the other hand, the effect of acetaminophen has not been sufficiently recognized due to the small doses (single dose, 300-500 mg; daily dose, 900-1500 mg/day) compared to other nations (single dose, 1,000 mg; daily dose, 4000-6000 mg/day). Further, the precautions for use indicated in the package insert of acetaminophen are the same as that indicated for NSAIDs; this may be a possible reason why acetaminophen has been misunderstood to be a kind of anti-inflammatory medication (NSAIDs) in Japan.From above-mentioned viewpoint, the dosage of acetaminophen and expression of the precautions in packaging insertion should be reconsidered. The dosage of acetaminophen as a nonprescription drug should also be reconsidered because the dosage in OTC is further lower than that of the prescription drug. It is expected that when a more reliable analgesic effect is obtained by the administration of a higher dosage of acetaminophen and a more accurate profile of its safety is recognized, this drug will become the first-choice analgesic in Japan.

著者

長嶋 友美 東海 林徹 中村 郁子 遠藤 泰 米澤 裕司 竹野 敏彦 小松﨑 康文 山﨑 浩 鬼頭 健二 田中 秀弥 山根 理恵子 村井 久美 池田 幸 斎藤 義夫 遠山 邦子 花岡 平司 鵜飼 孝子 外尾 典子 上中 清隆

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.35, no.1, pp.16-26, 2016 (Released:2016-05-10)

参考文献数

18

---

The purpose of the present study was to survey the use of antibacterial agents at 18 private dental college or university hospitals in Japan, as performed approximately every 10 years since 1983, and to identify the diseases treated with these medicines for longer than eight days at these dental hospitals. We first calculated the amount of antibacterial agents prescribed in October 2013. For internal and external preparations, almost all antibiotics comprised cephems (68%, 64%), penicillins (23%, 25%) and macrolides (7%, 8%), with values expressed in terms of percentage for outpatient and inpatient treatments, respectively, and these values were similar to previous surveys. The ratio of internal and external preparations was nearly six-fold higher when compared with injections. About 70% of oral cephems administrated to both outpatients and inpatients was cefcapene pivoxil hydrochloride. In contrast, the antibacterial injection administered to inpatients was primarily cefazolin sodium and that to outpatients was primarily ceftriaxone sodium hydrate. The ratio of carbapenems was less than 1%. Among the antibacterial agents administered for longer than eight days, clarithromycin was mainly used for the treatment of odontogenic chronic sinusitis. Our study suggested that clarithromycin was used appropriately in long-term treatment for chronic diseases. However, we found that a limited variety of oral cephems were heavily used for short-time administration, which might lead to the emergence of resistant bacteria. Pharmacist information and advice may be helpful for dentists to avoid it because proper pharmaceutical management of antibacterial agents is essential for the prevention of resistant bacteria.

著者

石塚 恭子 田中 健二郎 竹内 俊充 長澤 恒保 戸苅 彰史

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.3, pp.81-88, 2017 (Released:2017-12-27)

参考文献数

75

---

Fracture risk increases substantially with age due to decreased bone density and muscle mass, and also problems with vision and balance. In the elderly, medication used to treat non-skeletal disorders is one of the causes of bone fracture accompanying decreased QOL. Increased fracture risk by medication is based on either adverse drug reactions on bone metabolism or adverse drug events such as falls. The use of fall risk-increasing drugs (FRIDs), such as opioids, dopaminergic agents, anxiolytics, antidepressants and hypnotics/sedatives, have been demonstrated to increase risk of fracture. Furthermore, in addition to FRIDs, many drugs have been found to affect bone mass and fracture risk as a result of the side effects on bone metabolism. The present article reviews the current understanding of several drugs influencing fracture risk. In particular, drugs affecting fracture risk through sympathetic neuronal activity are also discussed.

著者

金坂 伊須萌 金山 明子 中西 康大 鈴木 崇嗣 金子 明寛 小林 寅喆

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.3, pp.100-105, 2015 (Released:2015-12-25)

参考文献数

18

---

We conducted a study about the antimicrobial susceptibility to ceftriaxone(CTRX)and prevalence of the genes cfxA/cfxA2 of clinical isolated Prevotella strains. Furthermore, we performed in vitro study for effects on the antibiotic treatment by mixed culture of β-lactamase producing Prevotella and Streptococcus mitis. All Prevotella isolates resistant to CTRX(MIC ≧32μg/mL)were found possess the cfxA/cfxA2. Prevalence of cfxA/cfxA2 of Prevotella isolates classified as susceptible by CLSI guidelines showing a MIC of ≦0.5μg/mL were less than 25% and a MIC of 1-16μg/mL were more than 73%. Viable cells of S. mitis showed more than 99% decrease in culture broth with CTRX at a concentration of 5μg/mL for up to 8 hours. In mixed culture of ESBL producing Prevotella oralis and S. mitis, viable cells of S. mitis was increased slightly in the presence of CTRX. The decrease of viable counts in S. mitis was not seen in the case of mixed culture of ESBL-producing P. oralis and S. mitis in the presence of CTRX at a concentration of 5μg/mL for up to 8 hours.   In conclusion, the cases of mixed infection with Prevotella and Oral Streptococci, it was suggested that the Prevotella producing ESBL caused an indirect pathogen for odontogenic infection.

著者

筒井 健機

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.20, no.2, pp.61-68, 2001-08-01 (Released:2010-06-08)

参考文献数

86

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.32, no.2, pp.101-107, 2013-05-25 (Released:2013-10-10)

著者

坂元 亮一 上川 善昭 永山 知宏 杉原 一正

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.29, no.1, pp.21-24, 2010-04-01 (Released:2010-08-20)

参考文献数

18

---

We report a case of angioedema in the tongue and oral floor potentially induced by angiotensin II receptor blockers (ARB).A 77-year-old woman with a history of hypertension was treated with an ARB, and edematous lesions in the tongue and oral floor suddenly occurred about one week after the start of the treatment. She visited an emergency hospital, and was prescribed serrapeptase, a complex of betamethasone and chlorpheniramine maleate, and epinastine hydrochloride. But since the edema was poorly controlled, she was referred to our department. The ARB was strongly suspected to have caused the angioedema, so we stopped the ARB that she was taking. Edema disappeared one day after the onset of symptoms, and there has been no recurrence of symptoms after the termination of ARB treatment.

著者

佐伯 万騎男

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.38, no.3, pp.191-194, 2019 (Released:2020-03-31)

参考文献数

13

---

Neuropathic pain is now defined by the International Association for the Study of Pain as pain caused by a lesion or disease of the somatosensory nervous system. The guidelines recommend tricyclic antidepressants, gabapentin or pregabalin, and duloxetine, a serotonin noradrenaline reuptake inhibitor, as first line. Mirogabalin, which is a novel ligand for the α2δ subunit of voltage-gated calcium channels, is being developed for treating neuropathic pain including diabetic peripheral neuropathy and postherpetic neuralgia. In this review, serendipitous discovery of pregabarin by Richard Silverman is discussed.

著者

角田 衣理加 大島 朋子 前田 伸子

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.28, no.1, pp.1-10, 2009-04-01 (Released:2009-12-22)

参考文献数

22

被引用文献数

1

---

Aromatherapy has been widely used in Europe as a phytotherapy for promoting general health or as a beauty treatment, however, the effectiveness of aromatherapy in the field of dentistry has not yet been determined.The purposes of this study were to estimate the anti-microbiological and anti-biofilm forming effects of essential oils against mutans streptococci, periodontal pathogens and oral indigenous true fungi. Seven essential oils, a blended essential oil with tea tree, peppermint, and lemon oils (TPL oils) which is known as a recommended blend for preventing halitosis, and one of the TPL oils replaced by another essential oil were used in this study. All tested essential oils showed anti-microbiological, anti-biofilm forming effects against the tested microorganisms. Specifically, lemongrass and peppermint oils had strong anti-microbiological effects. In addition, the anti-halitosis effect of a mouthwash containing 0.3% TPL oils was examined in ten periodontal patients. Volatile sulfur compounds, including hydrogen sulfide and methyl mercaptan, which are the main malodorous substances, tended to decrease after gargling with a mouthwash containing 0.3% TPL oils.The results of this study showed that essential oils indeed play a role in the treatment and prevention of oral diseases, especially periodontitis, candidiasis and halitosis, thereby suggesting the effectiveness of such essential oils.

著者

中川 洋一

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.35, no.1, pp.28-34, 2016 (Released:2016-05-10)

参考文献数

49

被引用文献数

3

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A global consensus regarding the terminology of dry mouth is needed in order to facilitate diagnosis and treatment as well as future research and education. This review summarizes the terms concerning dry mouth, including : xerostomia, hyposalivation, altered salivary composition, salivary gland dysfunction, and salivary dysfunction.

著者

金子 明寛

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.3, pp.85-93, 2015 (Released:2015-12-25)

参考文献数

27

被引用文献数

5

---

A number of odontogenic infections are often alleviated in a few days if inflammation is localized in the alveolar part, and appropriate surgical treatments such as incision or drainage as well as antibacterial chemotherapy are performed. However, in some cases, it may become desperately ill due to delay of the initial treatment and develop extremely serious infections including cellulitis or necrotic fasciitis. The causative bacteria for these diseases are oral resident microbiota, and are frequently detected in the case of multiple bacterial infection caused by obligate and facultative anaerobic bacteria. From odontogenic infection, Prevotella sp., Peptostreptococcus sp., and Streptococcus sp. are detected at high rate and are regarded as the three major etiologic agents. The change with time in susceptibility of strains separated from closed abscess of odontogenic infection during 7 years from 2005 to 2011 against various antibacterial agents was investigated. The results showed a decreasing tendency of susceptibility to β-lactam, macrolide, and quinolone agents. In particular, there are many β-lactamase producing strains in the Prevotella sp. Thus, it is necessary to select antibacterial agents stable for β-lactamase in patients with suspected involvement of obligate anaerobic bacteria such as cellulitis around the maxilla or deep neck abscess.

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.22, no.3, pp.169-170, 2003-12-01 (Released:2010-06-08)

著者

王 宝禮 砂川 正隆 山口 孝二郎 亀山 敦史 金子 明寛

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.34, no.1, pp.23-30, 2015-04-01 (Released:2015-06-01)

参考文献数

46

---

Kampo medicine has a long experience and actual performance over a long period of history. The first oriental medicine was approved by Japanese national health insurance in 1976, and 147 kinds of oriental medicine are currently approved by the National Health Insurance Drug Price. Those of 7 kinds of Kampo medicine were approved by Japan Dental Association of “National Health Insurance Drug Price Standard related with dental treatment” on April 2012. It has been reported that approximately 70 to 80% of doctors has an experience to use oriental medicine in a clinical site. Meanwhile, oriental medicine was used at more than 85% of medical facilities in a survey of Kampo medicine usage at oral surgery clinics in all Japanese Dental University hospital and Medical University hospital. However, only a few Kampo medicine was used at general dental clinics. Establishment of the evidence of oriental medical treatment in dental lesions is one of the solution of popularizing a treatment of Kampo medicine in oral surgery. Hence, efficacy of Kampo medicine which was approved by the new drug standard since 1986 was evaluated from the aspect of Evidence-based medicine(EBM).

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.18, no.3, pp.182-183, 1999-12-01 (Released:2010-06-08)

参考文献数

6

著者

安藤 崇仁 下尾 嘉昭 中里 政可 吉田 久博

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.31, no.2, pp.53-61, 2012-08-01 (Released:2012-09-06)

参考文献数

13

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歯科治療では浸潤麻酔が頻繁に行われている.しかし浸潤麻酔は患者に強い痛みを与えるため,前処置として表面麻酔が用いられており,口腔粘膜停滞性が悪く,麻酔効果も良好とは言い難い.そこで,表面麻酔薬塗布部の横に円筒形綿花を置き,さらに下口唇を術者が前方へ引き出すことで比較的簡便に表面麻酔薬の口腔粘膜停滞性を向上させる方法(改良法)を考案し,表面麻酔薬を塗布した後に口唇を閉じる方法(従来法)との間で試験を行った.複数の表面麻酔製剤を用い,表面麻酔効果の非使用部位への発現および浸潤麻酔時の除痛効果を検討した.対象は健常成人男女10名とし,試験部位は下顎前歯部歯槽粘膜とした.作用時間1分とし,注射針刺入時と薬液注入時の疼痛をVisual Analogue Scaleで評価した.その結果,改良法では,従来法よりも薬液注入時に良好な除痛効果を示した.また,従来法では1分以内に非使用部位で表面麻酔効果が認められたのに対し,改良法では認められなかった.これらの成績は,表面麻酔薬の口腔粘膜停滞性を向上させることにより副作用が軽減できること,また今回提示した改良法が薬剤の口腔粘膜停滞性向上に有効なことを示唆している.

著者

池田 裕子 岡本 真理子 山本 健 今村 武浩 山近 重生 斎藤 一郎 中川 洋一

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.33, no.1, pp.10-17, 2014-04-01 (Released:2014-09-05)

参考文献数

26

被引用文献数

4

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Purpose: The purpose of this study was to investigate sleep quality and its related factors in dry-mouth patients. Subjects and Methods: A cross-sectional study was conducted in 362 patients who visited the Dry Mouth Clinic at Tsurumi University Dental Hospital with the complaint of oral dryness. Sleep quality was assessed using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J), and factors associated with the PSQI-J global score were analyzed by multiple regression. The dependent variable was the PSQI-J global score, while age, gender, resting saliva flow rate (RSFR), stimulated saliva flow rate (SSFR), VAS score of nocturnal dry mouth sensation, the presence or absence of snoring, grinding, clenching, and mouth breathing, and anxiety and depression score in the Hospital Anxiety Depression Scale (HADS) were used as the independent variables. Results: The mean PSQI-J global score was 7.9±3.9, and 232/362 (64.1%) cases were considered to be poor sleepers who showed a score of less than 5.5. The multiple regression analysis showed that anxiety (standardizing coefficient 0.330) and depression score (0.151) in HADS, nocturnal dry-mouth sensation (0.165), and age (0.209) were significantly associated with the PSQI-J global score. Conclusion: Anxiety, depression, and sleep-related xerostomia were found to be factors closely associated with the risk of disturbance of good sleep quality.

著者

鎌谷 宇明 池田 幸 朽名 智彦 飯島 毅彦 吉濱 泰斗 近藤 誠二 代田 達夫 新谷 悟

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.31, no.3, pp.96-100, 2012-12-01 (Released:2013-02-25)

参考文献数

9

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Distigmine bromide is an anticholinesterase used to treat urinary retention. We describe a case of decreased serum cholinesterase caused by a usual oral dose of distigmine bromide for urinary retention. An 84-year-old man, who had been received chemotherapy for carcinoma of the lower gingiva, suddenly decreased serum cholinesterase to 21 IU/L in 7 days of administration of distigmine bromide 5mg without clinical symptoms. Serum cholinesterase improved after stopping the administration of distigmine bromide. This case shows that oral surgeons should be aware of the possibility of decreased serum cholinesterase in patients taking distigmine bromide.

著者

郡司 敦子 郡司 明彦 田村 幸彦 平尾 功治 町田 光 秋田 季子 小林 奈緒美 藤井 彰

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.28, no.3, pp.109-116, 2009-12-01

参考文献数

39

---

Acetaminophen is an antipyretic and analgesic drug that has a long history of 100 years or more and has been adopted in the WHO Model List of Essential Drugs in the category of non-opioids and non-steroidal anti-inflammatory medicines. In Japan, the analgesic effects of acetaminophen have not been sufficiently recognized, and NSAIDs have been used in the treatment of pain, even though acetaminophen is the first-choice analgesic worldwide.<br>Since acetaminophen, which is different from NSAIDs, does not inhibit the activity of COX-1 and COX-2, the risk of developing the 3 well-known adverse reactions of NSAIDs, peptic ulcer and gastrointestinal hemorrhage, renal dysfunction, and hemorrhage and platelet dysfunction, is very low. Aspirin is known to induce asthma and Reye's syndrome, however, acetaminophen is scarcely associated with these adverse reactions and can be used for treatment of viral diseases such as chicken pox and influenza. The safety of acetaminophen in pregnant women and elderly patients has been confirmed, and the position of acetaminophen as the first-choice analgesic drug has been established worldwide. In Japan, on the other hand, the effect of acetaminophen has not been sufficiently recognized due to the small doses (single dose, 300-500 mg; daily dose, 900-1500 mg/day) compared to other nations (single dose, 1,000 mg; daily dose, 4000-6000 mg/day). Further, the precautions for use indicated in the package insert of acetaminophen are the same as that indicated for NSAIDs; this may be a possible reason why acetaminophen has been misunderstood to be a kind of anti-inflammatory medication (NSAIDs) in Japan.<br>From above-mentioned viewpoint, the dosage of acetaminophen and expression of the precautions in packaging insertion should be reconsidered. The dosage of acetaminophen as a nonprescription drug should also be reconsidered because the dosage in OTC is further lower than that of the prescription drug. It is expected that when a more reliable analgesic effect is obtained by the administration of a higher dosage of acetaminophen and a more accurate profile of its safety is recognized, this drug will become the first-choice analgesic in Japan.

著者

豊福 明

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.36, no.3, pp.117-120, 2017 (Released:2017-12-27)

参考文献数

13

---

Historically, chronic oral pain with unknown origin had been treated as a “psychogenic” condition in dentistry. Although tricyclic antidepressants have been widely used to treat chronic oral pain such as glossodynia or atypical odontalgia, the mechanisms on how they work is not precisely elucidated still now. Strong evidences have been accumulated on pathophysiological interactions between chronic pain and psychosocial factors. Dopamine system has been found to play a key role for bridging chronic pain and psychosocial factors. To treat chronic oral pain better, we dentists should search for a new pharmacotherapy based on brain function, especially with a focus on the relationship between chronic oral pain and dysfunction of mesolimbic dopamine system.