著者
尾崎 勇 神成 一哉 馬場 正之
雑誌
青森県立保健大学雑誌 = Journai of Aomori University of Health and Welfare (ISSN:13493272)
巻号頁・発行日
vol.16, pp.31-36, 2016-03

【目的】パーキンソン病患者において,発病の危険因子と考えられている農薬ばく露について調査すること。【方法】2013 年7 月から11 月の間にA 県S 地方のM総合病院の神経内科外来に通院している患者に農薬ばく露に関するアンケート調査を実施した。調査票回収後にパーキンソン病(PD 群)とパーキンソン病以外の神経疾患(Non-PD 群)の2 群に分類して解析を行った。【結果】PD 群56 名(男性14 名,女性42 名,平均年齢74.1±9.9 歳(平均±標準偏差)),Non-PD 群81 名(男性29 名,女性52 名,平均年齢64.1±16.8 歳)であった。農薬ばく露スコア(最高点が8 点)の平均値はPD 群3.2±2.6 で,Non-PD 群1.9±2.2 で,2 群間で平均値も分布の型も統計学的に有意に異なっていた。PD 群では農業従事者の比率が高く,農薬ばく露の頻度が高かった。【結論】A 県S 地方ではパーキンソン病患者に占める農業従事者の比率,農薬ばく露の頻度ともに高かったことから,農薬ばく露がパーキンソン病発病の危険因子の1 つであることが確認された。【Purpose】We conducted a questionnaire survey on exposure to agricultural chemicals and risk ofParkinson disease.【Methods 】A short form of agricultural chemicals exposure questionnaire was developed. The questionnaire was administered to all patients who visited the outpatient clinic of Neurology, M GeneralHospital in the S district of A prefecture, between July 1 and November 30, 2013. The collected questionnaires were divided into two groups based on the clinical diagnosis of the patients; Parkinsondisease (PD) group and other neurological diseases (Non-PD) group.【Results 】PD group consisted of 56 patients (14 males, 42 females; mean age: 74.1±9.9 years (mean±standard deviation)).Non-PD group included 81 patients(29 males, 52 females; mean age: 64.1±16.8 years). The mean value of agricultural chemicals exposure score (the maximum score is 8) for PD group was 3.2±2.6 and that for Non-PD group, 1.9±2.2 ; The mean value and a pattern of distribution for agricultural chemicals exposure score differed between the two groups. In PD group, the ratio of thefarmer was high compared to Non-PD group and thereby, the incidence of agricultural chemicals exposure also was high.【Conclusions】We found that, in the S district of A prefecture, the ratio of the farmer and the incidence ofagricultural chemicals exposure are high in patients with PD and confirmed that agricultural chemicalsexposure is one of the risk factors for PD.