著者

西岡 雅行 福田 正博 根来 俊一 高田 実 楠 洋子 益田 典幸 瀧藤 伸英 松井 薫 中島 俊文 小野山 靖人

出版者

日本肺癌学会

雑誌

肺癌 (ISSN:03869628)

巻号頁・発行日

vol.31, no.3, pp.335-341, 1991-06-20

被引用文献数

2

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切除不能の肺非小細胞癌17例に対して,シスプラチン(100mg/m^2,day1),ビンデシン(3mg/m^2,dayl and day8)と胸部放射線照射(2Gy/day,day2〜15)の同時併用療法を行った.適格例は16例で,腫瘍効果はPR/2例,NC3例,PD1例,奏効率は75%であった.骨髄抑制は強く,食道炎も高頻度に発生したが一過性で,その他に重篤な合併症はみられなかった.本療法は許容範囲内の副作用で,高い奏効率が示されたことから,IIIA,IIIB期の切除不能肺非小細胞癌に有効な治療法と考えられた.

著者

福田 正博

出版者

Japan Oil Chemists' Society

雑誌

油化学 (ISSN:18842003)

巻号頁・発行日

vol.37, no.11, pp.973-978, 1988-11-20 (Released:2009-11-10)

参考文献数

26

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The behavior of surfactant aggregates in solutions was investigated by an ESR spin probe method. The following informations were obtained from analysis of spectra. 1) Two types of micelles were directly observed in commercially available sodium alkyl poly (oxyethylene) ether sulfate-alkyl poly (oxyethylene) ether mixed surfactant solutions. 2) Sodium dodecyl sulfate molecules (2 mM) incorporated into phospholipid bilayers (13.6 mM) formed clusters by themselves, causing phase separation of the bilayers. 3) Sodium 3- dodecyloxypoly (oxyethylene) -1-propane sulfonates interacted with an ESR spin probe even below the cmc. This was explained by the formation of ESR spin probe-induced micelles. 4) Butyl poly (oxypropylene) ether derivatives having polar dissociative functional groups on their terminal hydroxyl groups behaved in a manner similar to a reversed micelle or a W/O microemulsion system and were inverted to an O/W type through a transparent and viscoelastic gel stage with increasing a water content.