著者

愛場 庸雅 杉本 緑 松田 泰明 杉浦 欣一 中井 義明 中島 俊文

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.83, no.3, pp.391-395, 1990-03-01 (Released:2011-11-04)

参考文献数

12

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The effects of therapeutic irradiation on olfactory function were investigated in 20 patients who received radiation therapy because of a malignant tumor of the nose or paranasal sinuses. The standard olfaction test with a T&T olfactometer and an intravenous olfaction test were given before the radiation therapy, during the period of radiation therapy and 1, 3, 6 and 12 months or more later.Five patients whose olfactory epithelium was outside the radiation field showed no damage to olfactory function. The olfactory function of the other 15 patients whose olfactory epithelium had been exposed to radiation was not obviously changed or damaged at the time of radiation therapy. However, 6 months after irradiation, some patients showed a decline in olfactory function, and after 12 months, 4 of 7 patients showed severe damage to olfactory function.These results suggest that a therapeutic dose of irradiation will not cause severe damage to the olfactory function during the period of radiation therapy, but could cause delayed olfactory disorders in some patients after a few years. These olfactory disorders might be caused by damage to or degeneration of the olfactory epithelium or olfactory nerve.

著者

西岡 雅行 福田 正博 根来 俊一 高田 実 楠 洋子 益田 典幸 瀧藤 伸英 松井 薫 中島 俊文 小野山 靖人

出版者

日本肺癌学会

雑誌

肺癌 (ISSN:03869628)

巻号頁・発行日

vol.31, no.3, pp.335-341, 1991-06-20

被引用文献数

2

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切除不能の肺非小細胞癌17例に対して,シスプラチン(100mg/m^2,day1),ビンデシン(3mg/m^2,dayl and day8)と胸部放射線照射(2Gy/day,day2〜15)の同時併用療法を行った.適格例は16例で,腫瘍効果はPR/2例,NC3例,PD1例,奏効率は75%であった.骨髄抑制は強く,食道炎も高頻度に発生したが一過性で,その他に重篤な合併症はみられなかった.本療法は許容範囲内の副作用で,高い奏効率が示されたことから,IIIA,IIIB期の切除不能肺非小細胞癌に有効な治療法と考えられた.