著者

加藤 正博 稲葉 美代志 板鼻 秀信 大原 英治 中村 好一 上里 新一 井上 博之 藤多 哲朗

出版者

日本生薬学会

雑誌

生薬学雑誌 (ISSN:00374377)

巻号頁・発行日

vol.44, no.4, pp.288-292, 1990

被引用文献数

2

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Twentythree crude drugs and related plants were examined for their anticoccidial activity by the use of the experimental coccidiosis in chicken. The activity was found in the dry leaves and calyxes of some Hydrangea plants. As the active components of H. macrophylla subsp. macrophylla forma macrophylla, febrifugines were isolated which have been known to be contained in Dichroa febrifuga and H. umbellata. However, although the febrifugines in the latter two plants were reported to be mainly trans, in the H. macrophylla plants, cis-febrifugine was found to be a major component and the trans-counterpart, a minor component. Furthermore, the cis-isomer showed no anticoccidial activity in chicken even at the concentration level of 25 times the effective dose (3 ppm, IE=100) of the trans-isomer.