1 0 0 0 OA バレイショデンプンの諸物性におよぼす軽質無水ケイ酸の疎水化物並びに含有水分の影響
- 著者
- 林 弘祐 笠野 俊彦 須原 清治
- 出版者
- The Society of Powder Technology, Japan
- 雑誌
- 粉体工学会誌 (ISSN:03866157)
- 巻号頁・発行日
- vol.18, no.1, pp.3-10, 1981-01-10 (Released:2010-04-30)
- 参考文献数
- 8
The effect of the addition of light anhydrous silicic acid to potato starch powdes, which improves the lubricating characteristics of drug powders, is usually cancelled by the absorption of moisture. In order to improve this point, hydrophobic light anhydrous silicic acid was used, and prevention of the loss of the lubricating effect by moisture sorption was examined.1) Moisture sorption of the mixture of dry starch and silicic acid (0.1%) results in the increase of the apparent specific volume and angle of repose, and decrease of dispersibility, with the increase in water content. The resultant mixture shows powder characteristics close to that of starch, that is the lubricating effect of light anhydrous silicic acid is lost. When 0.1% hydrophobic silicic acid is added, its effect was almost the same as when added to moistened starch, and the lubricating effect of hydrophobic silicic acid was not lost due to moisture sorption by starch.2)Examination of such mixtures by a scanning electron microscope revealed that ordinary light anhydrous silicic acid stuck to starch granules that looked like the moistened thin paper to be stuck when light anhydrous silicic acid experienced moisture sorption, and light anhydrous silicic acid could not prevent the contact of the starch granules. This resulted in the reappearance of powder characteristics in starch itself. In the case of hydrophobic light anhydrous silicic acid, the particles do not stick to or fall from starch granules even after moisture sorption and remain attached sterically to the starch granules the same as after their addition, and prevent the contact of starch granules themselves. This is considered to be one of the reasons why hydrophobic light anhydrous silicic acid does not lose its lubricating effect.
1 0 0 0 OA 粒子径等により物性を変えた医薬品に対する軽質無水ケイ酸め添加効果
- 著者
- 林 弘祐 笠野 俊彦 須原 清治
- 出版者
- 一般社団法人 日本医療薬学会
- 雑誌
- 病院薬学 (ISSN:03899098)
- 巻号頁・発行日
- vol.7, no.2, pp.108-117, 1981 (Released:2011-08-11)
- 参考文献数
- 6
Pharmaceutical preparations such as sodium bicarbonate, lactose and potato starch show 2 different physical properties depending on their crystal diameters and moisture contents. Light anhydrous silicic acid (LASA) was added in several levels to 2 forms of the above preparations in order to investigate how these amounts of addition cause differences in their physical properties. Results are as follows:1) The angle of repose was minimized when LASA was added to powdered sodium bicarbonate in a proportion ranging from 0.1 to 0.25% and became greater in proportions exceeding 0.25%. Both the angle of repose and apparent specific volume of crystalline sodium bicarbonate were minimized by addition of LASA 0.01% and became greater in proportions exceeding 0.5%.2) In the case of powdered lactose, addition of LASA 0.01%resulted in negligible improvement in the physical properties. The effect was maximum in the proportion of 0.25%. In the case of crystalline lactose, addition of LASA even in 0.01% improved the physical properties. The effect was slightly enhanced by addition of LASA up to 0.1%. However, the addition of LASA in the proportion ranging from 0.25 to 0.5% deteriorated the effect.3) The degree of improvement in the physical properties of wet and dry potato starch reached maximum by addition of LASA 0.25 and 0.05%, respectively. The effect on wet stacrch by addition of LASA was greater.4) Scanning electron microscopy for observing the mixed conditions revealed that larger number of LASA particles attached to particles of the preparations when the physical properties were improved to a greater extent, and further increased proportions of addition resulted in the tendency to deteriorate physical properties by generation of aggregated particles of LASA attached particles of the preparations.