著者

菅原 拓也 荒井 浩一 倉本 敬二 東海林 徹 浅倉 聖岳 白石 正

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.42, no.10, pp.678-686, 2016-10-10 (Released:2017-10-10)

参考文献数

18

被引用文献数

1

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We previously reported that insoluble particulate matter formed during the mixing of injectable drugs. We considered that the contamination derived from the disposable injection syringe used for the mixture as one of the causes. Therefore, in the present study, we evaluated the amount of insoluble particulate matter caused by using a 50-mL syringe of each manufacturer, using syringes of various capacities and number of piston times (suction and expulsion) of the syringe. Furthermore, we were able to identify the components of the insoluble particulate matter that formed. As a result, we found that a lot of insoluble particulate matter was expelled from the 50-mL syringes of each manufacturer that increased with the capacity of the syringe and the number of piston times. In addition, we found that the insoluble particulate matter was from the silicone oil coating on the inner surfaces of the syringes.